| |
Article Title |
Author(s) |
Pages |
|
|
|
Editorial Board
|
|
CO2
|
|
| Invited Review |
| |
Article Title |
Author(s) |
Pages |
|
|
|
What do kinase inhibition profiles tell us about tyrosine kinase inhibitors used for the treatment of CML?
13 October 2011
Abstract: Cancer treatment has long been based upon cytotoxic therapies that affect all rapidly dividing cells, and as such, is necessarily associated with significant toxicity. More recently, drugs t...
|
Michael W. Deininger,
Paul Manley
|
253-261
|
|
| Guest Editorial |
| |
Article Title |
Author(s) |
Pages |
|
|
|
Imatinib does not impair gonadal function
02 December 2011
The Bcr-Abl tyrosine kinase inhibitor, imatinib, was introduced into the armamentarium for the treatment of chronic myeloid leukemia (CML) and has revolutionized the management and significantly impro...
|
Charles Chuah
|
262-263
|
|
| Meeting Report |
| |
Article Title |
Author(s) |
Pages |
|
|
|
Update on developments in the diagnosis and prognostic evaluation of patients with myelodysplastic syndromes (MDS): Consensus statements and report from an expert workshop
05 December 2011
Abstract: Several new treatments for myelodysplastic syndromes (MDS) have recently become available, or are in development. Patients who could benefit from active treatment must be effectively identif...
|
Uwe Platzbecker,
Valeria Santini,
Ghulam J. Mufti,
Claudia Haferlach,
Jaroslaw P. Maciejewski,
Sophie Park,
Francesc Solé,
Arjan A. van de Loosdrecht,
Detlef Haase
et al.
|
264-270
|
|
| Clinical Studies |
| |
Article Title |
Author(s) |
Pages |
|
|
|
Imatinib mesylate at therapeutic doses has no impact on folliculogenesis or spermatogenesis in a leukaemic mouse model
24 October 2011
Abstract: Imatinib should be avoided in women planning to become pregnant or during pregnancy, due to a higher risk of congenital malformations. However, it is not known whether imatinib affects futur...
|
Beate Schultheis,
Bart A. Nijmeijer,
H. Yin,
Roger G. Gosden,
Junia V. Melo
et al.
|
271-274
|
|
|
|
Elevated Fas/FasL system and endothelial cell microparticles are involved in endothelial damage in acute graft-versus-host disease: A clinical analysis
15 September 2011
Abstract: Acute graft-versus-host disease (aGVHD) is the major cause of early morbidity and mortality in allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients, but its mechanism re...
|
Qiuling Wu,
Huixin Chen,
Jun Fang,
Wei Xie,
Mei Hong,
Linghui Xia
et al.
|
275-280
|
|
|
|
SDF-1/CXCR4 axis in myelodysplastic syndromes: Correlation with angiogenesis and apoptosis
29 July 2011
Abstract: To study the role of SDF-1/CXCR4 axis in MDS, the expression of SDF-1 and CXCR4, VEGF, MVD and apoptosis were measured in MDS. The results showed that the expression of SDF-1 of the low-grad...
|
Yizhuo Zhang,
Haifeng Zhao,
Dandan Zhao,
Lu Sun,
Yaqin zhi,
Xiaoxiong Wu,
Wenrong Huang,
Wanming Da
et al.
|
281-286
|
|
|
|
The degree of neutropenia has a prognostic impact in low risk myelodysplastic syndrome
02 December 2011
Abstract: The severity of neutropenia in myelodysplastic syndrome (MDS) has not been completely studied. We analyzed the prognostic significance of severe neutropenia (neutrophils count<0.5×109/L) ...
|
I. Cordoba,
J.R. Gonzalez-Porras,
E. Such,
B. Nomdedeu,
E. Luño,
R. de Paz,
F. Carbonell,
T. Vallespi,
M. Ardanaz,
F. Ramos,
V. Marco,
S. Bonanad,
M. Sanchez-Barba,
D. Costa,
T. Bernal,
G.F. Sanz,
M.C. Cañizo
et al.
|
287-292
|
|
|
|
Differential MiRNA expression in childhood acute lymphoblastic leukemia and association with clinical and biological features
18 November 2011
Abstract: The present study aimed to analyze the expression profile of the microRNAs previously described as associated with childhood ALL, miR-92a, miR-100, miR-125a-5p, miR-128a, miR-181b, miR-196b ...
|
Jaqueline Carvalho de Oliveira,
Carlos Alberto Scrideli,
María Sol Brassesco,
Andressa Gois Morales,
Julia Alejandra Pezuk,
Rosane de Paula Queiroz,
José Andres Yunes,
Silvia Regina Brandalise,
Luiz Gonzaga Tone
et al.
|
293-298
|
|
|
|
Interactions between acute lymphoblastic leukemia and bone marrow stromal cells influence response to therapy
05 September 2011
Abstract: The cure rate for pediatric patients with B precursor acute lymphoblastic leukemia (pre-B ALL) is steadily improving, however relapses do occur despite initial response to therapy. To identi...
|
Yordanos Tesfai,
Jette Ford,
Kim W. Carter,
Martin J. Firth,
Rebecca A. O’Leary,
Nicholas G. Gottardo,
Catherine Cole,
Ursula R. Kees
et al.
|
299-306
|
|
|
|
A new minimal deleted region at 11q22.3 reveals the importance of interpretation of diminished FISH signals and the choice of probe for ATM deletion screening in chronic lymphocytic leukemia
28 September 2011
Abstract: Deletion of ATM detected by fluorescent in situ hybridization (FISH) in chronic lymphocytic leukemia predicts short treatment free survival and poor outcome following alkylator/purine analog...
|
Anne Gardiner,
Helen Parker,
Sharron Glide,
Sarah Mould,
Hazel Robinson,
Ian Tracy,
Tanja Stankovic,
David Oscier,
Jon Strefford
et al.
|
307-310
|
|
|
|
Rituximab for the treatment of adult relapsed/refractory CD20 positive B-ALL patients: A pilot series
15 December 2011
Abstract: No series have reported the results of the use of the therapeutic anti-CD20 monoclonal antibody (Rituximab) in the setting of adult refractory/relapsed B-ALL. We report here the outcomes of ...
|
Patrice Chevallier,
Arnaud Pigneux,
Nelly Robillard,
Sameh Ayari,
Thierry Guillaume,
Jacques Delaunay,
Marion Eveillard,
Pierre-Yves Dumas,
Eric Lippert,
Mohamad Mohty,
Thibaut Leguay
et al.
|
311-315
|
|
|
|
Minimal residual disease monitoring based on FLT3 internal tandem duplication in adult acute myeloid leukemia
02 December 2011
Abstract: FLT3 internal tandem duplication (FLT3-ITD) is usually considered as a bad marker for minimal residual disease (MRD) follow-up in acute myeloid leukemia (AML). Our objective was to evaluate ...
|
Emna Abdelhamid,
Claude Preudhomme,
Nathalie Helevaut,
Olivier Nibourel,
Claude Gardin,
Philippe Rousselot,
Sylvie Castaigne,
Bérengère Gruson,
Céline Berthon,
Zohra Soua,
Aline Renneville
et al.
|
316-323
|
|
| Brief Communications |
| |
Article Title |
Author(s) |
Pages |
|
|
|
Influence of JAK2 46/1 haplotype in the natural evolution of JAK2V617F allele burden in patients with myeloproliferative neoplasms
17 October 2011
Abstract: JAK2V617F allele burden was prospectively measured in untreated patients with polycythaemia vera (PV, n=26) or essential thrombocythaemia (ET, n=36) and compared according to JAK2 46/1 haplo...
|
Alberto Alvarez-Larrán,
Anna Angona,
Luz Martínez-Avilés,
Beatriz Bellosillo,
Carlos Besses
et al.
|
324-326
|
|
|
|
The long term risk of myelodysplastic syndromes among anemia patients: A population-based study
06 December 2011
Abstract: We have utilized the computerized data of a nationwide health plan to elucidate several epidemiologic aspects and risk factor of myelodysplastic syndromes (MDS) in Israel. The annual inciden...
|
D. Meytes,
G. Chodick,
V. Shalev,
A. Porath
|
327-330
|
|
|
|
Impaired bactericidal and fungicidal activities of neutrophils in patients with myelodysplastic syndrome
16 December 2011
Abstract: Infections are a major cause of morbidity and mortality in patients with myelodysplastic syndrome (MDS) due to quantitative and qualitative granulocytic defects. We evaluated the in vitro ba...
|
Luana Fianchi,
Giuseppe Leone,
Brunella Posteraro,
Maurizio Sanguinetti,
Francesco Guidi,
Caterina Giovanna Valentini,
Maria Teresa Voso,
Livio Pagano
et al.
|
331-333
|
|
| Laboratory Studies |
| |
Article Title |
Author(s) |
Pages |
|
|
|
miR-590-5p, miR-219-5p, miR-15b and miR-628-5p are commonly regulated by IL-3, GM-CSF and G-CSF in acute myeloid leukemia
24 October 2011
Abstract: Aberrations in IL-3, GM-CSF and G-CSF induced signaling are frequently reported in acute myeloid leukemia (AML). Herein, we utilized a unique human myeloid leukemic cell line, AML-193, which...
|
Amanda J. Favreau,
Pradeep Sathyanarayana
|
334-341
|
|
|
|
Synergistic activity of rapamycin and dexamethasone in vitro and in vivo in acute lymphoblastic leukemia via cell-cycle arrest and apoptosis
05 December 2011
Abstract: Activation of the mTOR pathway subsequent to phosphatase and tensin homolog (PTEN) mutation may be associated with glucocorticoid (GC) resistance in acute lymphoblastic leukemia (ALL). The c...
|
Chong Zhang,
Yong-Ku Ryu,
Taylor Z. Chen,
Connor P. Hall,
Daniel R. Webster,
Min H. Kang
et al.
|
342-349
|
|
|
|
A combination of methotrexate and irradiation promotes cell death in NK/T-cell lymphoma cells via down-regulation of NF-κB signaling
07 September 2011
Abstract: Nasal NK/T-cell lymphoma (NKTL) is a highly aggressive disease. Although radiotherapy is the first-line of treatment for NKTL, the clinical outcome is poor. Thus, there is a need for an effe...
|
Areumnuri Kim,
Jung-Eun Lee,
Won-Suk Jang,
Sun-Joo Lee,
Sunhoo Park,
Hye Jin Kang,
Seung-Sook Lee
et al.
|
350-357
|
|
|
|
CD44 activation enhances acute monoblastic leukemia cell survival via Mcl-1 upregulation
13 October 2011
Abstract: Survival of acute myeloid leukemia (AML) cells is regulated by their adherence to bone marrow stromal environment. Several adhesion molecules mediate interactions between AML cells and strom...
|
Arnaud Sansonetti,
Sébastien Bourcier,
Laetitia Durand,
Christine Chomienne,
Florence Smadja-Joffe,
Jacqueline Robert-Lézénès
et al.
|
358-362
|
|
|
|
Combination of atiprimod and the proteasome inhibitor bortezomib induces apoptosis of mantle cell lymphoma in vitro and in vivo
14 October 2011
Abstract: The proteasome inhibitor bortezomib (BTZ) is known to be chemotherapeutic in relapsed or refractory mantle cell lymphoma (MCL). Atiprimod (ATI), a novel cationic amphophilic compound, has be...
|
Luhong Sun,
Liang Zhang,
Jianfei Qian,
Jing Yang,
Qing Yi,
Wenli Dong,
Michael Wang
et al.
|
363-368
|
|
|
|
Retrovirus-transformed erythroleukemia cells induce central nervous system failure in a new syngeneic mouse model of meningeal leukemia
19 September 2011
Abstract: Lack of suitable mouse models for central nervous system (CNS)-associated leukemias has hindered mechanism-guided development of therapeutics. By transplanting retrovirus-transformed mouse e...
|
Gordon R. Macpherson,
Charlotte A. Hanson,
Delores M. Thompson,
Christine M. Perella,
Joan L. Cmarik,
Sandra K. Ruscetti
et al.
|
369-376
|
|
| Case of the Month |
| |
Article Title |
Author(s) |
Pages |
|
|
|
Unique association of systemic mastocytosis and myeloid/lymphoid neoplasm in blast crisis with abnormality of FGFR1 gene
26 October 2011
Mastocytosis is a heterogeneous group of diseases characterized by abnormal growth and accumulation of mast cells . It is now classified as a myeloproliferative neoplasm or MPN in the 2008 World Healt...
|
Caroline Mayeur-Rousse,
Nathalie Sorel,
Maud Voldoire,
Danielle Canioni,
Françoise Brizard,
Edouard Randriamalala,
Ali G. Turhan,
Jean-Claude Chomel
et al.
|
377-381
|
|
| E-page Letters (available online only) |
| |
Article Title |
Author(s) |
Pages |
|
|
|
Deletion of the long arm but not the 5q31 region of chromosome 5 in myeloid malignancies
08 December 2011
Deletion of the long arm of chromosome 5 is a recurrent cytogenetic abnormality that is frequently found in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). The commonly deleted regio...
|
Jana Brezinova,
Zuzana Zemanova,
Dagmar Bystricka,
Iveta Sarova,
Libuse Lizcova,
Eva Malinova,
Silvia Izakova,
Jana Sajdova,
Dana Sponerova,
Anna Jonasova,
Jaroslav Cermak,
Kyra Michalova
et al.
|
e43-e45
|
|
|
|
Erythroleukemia presenting with myeloid sarcoma of the lung as detected by immunophenotypic analysis of bronchoalveolar lavage fluid
15 December 2011
Myeloid sarcoma (MS) is an extramedullary tumor mass composed by immature myeloid cells, that may develop concurrently with acute myeloid leukemia (AML). Although MS can occur in any site, lung involv...
|
Clara Cesana,
Laura Marbello,
Barbara Scarpati,
Elisabetta Calzavara,
Angelo Vanzulli,
Silvia Soriani,
Annamaria Nosari,
Enrica Morra
et al.
|
e46-e49
|
|
|
|
Absence of mutations in the activation loop and juxtamembrane domains of VEGFR-1 and VEGFR-2 gene in chronic myelomonocytic leukemia (CMML)
07 December 2011
Angiogenesis is recognized as a main feature of many human neoplasms. Vascular endothelial growth factor (VEGF) is a potent angiogenic peptide with exerts its biologic effects by interaction with eith...
|
Esperanza Such,
José Cervera,
Mariam Ibáñez,
Inés Gómez-Seguí,
Irene Luna,
María López-Pavía,
Mar Mallo,
Rosa Collado,
Ana Vicente,
Juan Carlos Hernández-Boluda,
Elisa Luño,
Rafael Andreu,
Guillermo F. Sanz,
Miguel A. Sanz
et al.
|
e50-e51
|
|
|
|
Atraumatic splenic rupture in patients with myelodysplastic syndromes: Report of a case occurred during treatment with 5-azacitidine and review of the literature
15 December 2011
A 62-year old Caucasian woman with a previous history of arterial hypertension, dilative cardiomyopathy and cerebral transient ischemic attack, was admitted to our Department because of marked fatigue...
|
Fabio Forghieri,
Monica Morselli,
Giovanna Leonardi,
Leonardo Potenza,
Goretta Bonacorsi,
Valeria Coluccio,
Ambra Paolini,
Monica Maccaferri,
Elisabetta Colaci,
Valeria Fantuzzi,
Sara Bigliardi,
Piera Zaldini,
Giovanni Riva,
Patrizia Barozzi,
Luca Leonardi,
Aldo Rossi,
Roberto Marasca,
Franco Narni,
Mario Luppi
et al.
|
e52-e56
|
|
|
|
Spontaneous, transient regression of B lymphoblastic leukemia in an adult patient: A variant presentation of prodromal/pre-ALL
02 December 2011
Rarely, acute lymphoblastic leukemia (ALL) can present after a brief preleukemic phase of pancytopenia/bone marrow failure, followed by transient and spontaneous normalization of bone marrow cellulari...
|
Chaiyaporn Boonchalermvichian,
Yi Xie,
Russell K. Brynes,
Imran N. Siddiqi
|
e57-e59
|
|
|
|
Clinical profile and outcome of patients of acute myeloid leukemia with high hyperdiploidy
05 December 2011
Acute myeloid leukemia (AML) is rarely associated with hyperdiploidy. Hyperdiploidy is included under complex karyotype in AML. High hyperdiploidy, i.e. near triploidy and tetraploidy is even rare cyt...
|
Sanjeev Kumar Sharma,
Monica Sharma,
Tulika Seth,
Pravas Mishra,
Mohit Chowdhry,
Manoranjan Mahapatra,
Renu Saxena
et al.
|
e60-e61
|
|
