Leukemia Research
Volume 24, Issue 4 , Pages 353-358 , April 2000

Unusual CD4+CD8+ phenotype in a Greek patient diagnosed with adult T-cell leukemia positive for human T-cell leukemia virus type I (HTLV-I)

  • Vincenzo Ciminale

      Affiliations

    • Present address: Department of Oncology and Surgical Sciences, University of Padova, Italy.
    • ABL-Basic Research Program, Human Retrovirus Section, National Cancer Institute — Frederick Cancer Research and Development Center, Room 210, Building 535, Sultan Street, Frederick, MD 21702-1201, USA
    • ,
  • Maria Hatziyanni

      Affiliations

    • Department of Hematology, Metaxa Cancer Hospital of Piraeus, Piraeus 18537, Greece
    • ,
  • Barbara K Felber

      Affiliations

    • Human Retrovirus Pathogenesis Section, National Cancer Institute — Frederick Cancer Research and Development Center, ABL-Basic Research Program, Frederick, MD 21702-1201, USA
    • ,
  • Jenifer Bear

      Affiliations

    • Human Retrovirus Pathogenesis Section, National Cancer Institute — Frederick Cancer Research and Development Center, ABL-Basic Research Program, Frederick, MD 21702-1201, USA
    • ,
  • Angelos Hatzakis

      Affiliations

    • Department of Hygiene and Epidemiology, Athens University Medical School, Athens 11572, Greece
    • ,
  • George N Pavlakis

      Affiliations

    • ABL-Basic Research Program, Human Retrovirus Section, National Cancer Institute — Frederick Cancer Research and Development Center, Room 210, Building 535, Sultan Street, Frederick, MD 21702-1201, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1-301-8461474; fax: +1-301-8466368/7146

Received 19 August 1999 ,Accepted 6 November 1999.

References 

  1. Franchini G. Molecular mechanisms of human T-cell leukemia/lymphotropic virus type I infection. Blood. 1995;86:3619–3639
  2. Hattori T, Uchiyama T, Toninai T, Takasuki K, Uchino H. Surface phenotype of Japanese ATL cells characterized by MoABs. Blood. 1981;58:645
  3. Yamada Y. Phenotypic and functional analysis of leukemic cells from 16 patients with adult T-cell leukemia/lymphoma. Blood. 1983;61:192
  4. Yamaguchi K, Takasuki K. Adult T-cell leukaemia-lymphoma. Clin. Haematol. 1993;6:899
  5. Tamura K, Unoki T, Sagawa K, et al.  Clinical features of OKT4+/OKT8+ adult T-cell leukemia. Leuk. Res. 1985;9:1353–1359
  6. Tamura K, Makino S, Araki Y, et al.  A case of CD4+/CD8− adult T-cell leukemia with good response to interferon-beta terminating as a CD4+/CD8+ adult T-cell lymphoma. Leuk. Res. 1987;11:665–668
  7. Kamihira S, Sohda H, Atogami S, et al.  Phenotypical diversity and prognosis of adult T-cell leukemia. Leuk. Res. 1992;16:435
  8. Ohata J, Matsuoka M, Yamashita T, Tojo A, Tani K, Asano S. CD4/CD8 double-positive adult T cell leukemia with preceding cytomegaloviral gastroenterocolitis. Int. J. Hematol. 1999;69:92–95
  9. The HTLV European Research Net Work . Seroepidemiology of the human T-cell leukaemia/lymphoma viruses in Europe. J. AIDS Hum. Retrovirol. 1996;13:68–77
  10. Gessain A, Gallo RC, Franchini G. Low degree of human T-cell leukemia/lymphoma virus type I genetic drift in vivo as a means of monitoring viral transmission and movement of ancient human populations. J. Virol. 1992;66:2288–2295
  11. Gessain A, Koralnik IJ, Fullen J, et al.  Phylogenetic study of ten new HTLV-I strains from the Americas. AIDS. Res. Hum. Retr. 1994;10:103–106
  12. Derse D, Mikovits J, Polianova M, Felber BK, Ruscetti F. Virions released from cells transfected with a molecular clone and of HTLV-1 give rise to primary and secondary infections of T-Cells. J. Virol. 1995;69:1907–1912
  13. Koyanagi Y, Itoyama Y, Nakamura N, et al.  In vivo infection of human T-cell leukemia virus type I in non-T cells. Virology. 1993;196:25–33
  14. Hadzopoulou-Cladaras M, Felber BK, Cladaras C, Athanassopoulos A, Tse A, Pavlakis GN. The rev (trs/art) protein of human immunodeficiency virus type 1 affects viral mRNA and protein expression via a cis-acting sequence in the env region. J. Virol. 1989;63:1265–1274

PII: S0145-2126(99)00193-9

Leukemia Research
Volume 24, Issue 4 , Pages 353-358 , April 2000

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