Leukemia Research
Volume 24, Issue 4 , Pages 339-347 , April 2000

Prediction and reversion of post-transplant relapse in patients with chronic myeloid leukemia using mixed chimerism and residual disease detection and adoptive immunotherapy

  • Renata Formánková

      Affiliations

    • Institute of Hematology and Blood Transfusion, Prague, Czech Republic
    • Second Department of Pediatrics, Second Medical School, Charles University, V Uvalu 84, 150 06 Prague 5, Czech Republic
    • Corresponding Author InformationCorresponding author. Tel./fax: +420-2-24432220
  • ,
  • Lenka Honzátková

      Affiliations

    • Institute of Hematology and Blood Transfusion, Prague, Czech Republic
  • ,
  • Jana Moravcová

      Affiliations

    • Institute of Hematology and Blood Transfusion, Prague, Czech Republic
  • ,
  • Zuzana Sieglová

      Affiliations

    • Institute of Hematology and Blood Transfusion, Prague, Czech Republic
  • ,
  • Renata Dvořáková

      Affiliations

    • Institute of Hematology and Blood Transfusion, Prague, Czech Republic
  • ,
  • Sylvie Nádvornı́ková

      Affiliations

    • Institute of Hematology and Blood Transfusion, Prague, Czech Republic
  • ,
  • Antonı́n Vı́tek

      Affiliations

    • Institute of Hematology and Blood Transfusion, Prague, Czech Republic
  • ,
  • Marcela Lukášová

      Affiliations

    • Institute of Hematology and Blood Transfusion, Prague, Czech Republic
  • ,
  • Jan Starý

      Affiliations

    • Second Department of Pediatrics, Second Medical School, Charles University, V Uvalu 84, 150 06 Prague 5, Czech Republic
  • ,
  • Radim Brdička

      Affiliations

    • Institute of Hematology and Blood Transfusion, Prague, Czech Republic

Received 25 May 1999 ,Accepted 2 October 1999.

References 

  1. Goldman JM, Apperley JF, Marcus R, Goolden AWG, Batchelor R, Hale G, et al. Bone marrow transplantation for patients with chronic myeloid leukemia. New Engl. J. Med. 1986;314:202
  2. Radisch JP, Gehly G, Gooley T, Bryant E, Clift RA, Collins S, et al. Polymerase chain reaction detection of the BCR-ABL fusion transcript after allogeneic marrow transplantation for chronic myeloid leukemia: results and implications in 346 patients. Blood. 1995;85:2632
  3. Cross NCP, Hughes TP, Lin F, Feng L, O’Shea P, Bungey J, et al. Minimal residual disease after allogeneic bone marrow transplantation for chronic myeloid leukemia in first chronic phase: correlations with acute-graft versus-host disease and relapse. Br. J. Haematol. 1993;84:67
  4. Hochhaus A, Lin F, Reiter A, Skladny H, Mason PJ, van Rhee F, et al. Quantification of residual disease in chronic myelogenous leukemia patients on interferon-alpha therapy by competitive polymerase chain reaction. Blood. 1996;87:1549
  5. Lion T. Clinical implications of qualitative and quantitative polymerase chain reaction analysis in the monitoring of patients with chronic myelogenous leukemia. Bone Marrow Transplant. 1994;14:505
  6. Moravcová J, Lukášová M, Starý J, Haškovec C. Simple competitive two-step RT-PCR assay to monitor minimal residual disease in CML patients after bone marrow transplantation. Leukemia. 1998;12:1303
  7. Browne PV, Lawrer M, O′Riordan J, Humphries P, McCann SR. Early detection of leukaemic relapse after bone marrow transplantation using the polymerase chain reaction. Bone Marrow Transplant. 1991;7:167
  8. McCann SR, Lawrer M. Mixed chimerism; detection and significance following BMT. Bone Marrow Transplant. 1993;11:91
  9. Socie G, Lawrer M, Gluckman E, McCann SR, Brison O. Studies on hemopoietic chimerism following allogeneic bone marrow transplantation in the molecular biology area. Leuk. Res. 1995;19:497
  10. Suttorp M, Schmitz N, Dreger P, Schaub J, Loffler H. Monitoring of chimerism after allogeneic bone marrow transplantation with unmanipulated marrow by use of DNA polymorphisms. Leukemia. 1993;7:679
  11. Elmaagacli AH, Beelen DW, Becks HW, Mobascher A, Stockova J, Trzensky S, et al. Molecular studies of chimerism and minimal residual disease after allogeneic peripheral blood progenitor cells or bone marrow transplantation. Bone Marrow Transplant. 1996;18:397
  12. Mackinnon S, Barnett L, Heller G, O’Reilly RJ. Minimal residual disease is more common in patients who have mixed T-cell chimerism after bone marrow transplantation for chronic myelogenous leukemia. Blood. 1994;83:3409
  13. Bader P, Beck J, Frey A, Schlegel PG, Hebarth H, Handgretinger R, et al. Serial and quantitative analysis of mixed hematopoietic chimerism by PCR patients with acute leukemias allows the prediction of relapse after allogeneic BMT. Bone Marrow Transplant. 1998;21:487
  14. Chalmers EA, Sproul AM, Mills KI, Gibson BES, Burnett AK. Use of polymerase chain reaction to monitor engraftment following allogeneic bone marrow transplantation. Bone Marrow Transplant. 1990;6:399
  15. Miller SA, Dykes DD, Polesky HF. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res. 1988;85:1215
  16. Guistincich S, Manfioletti G, Del Sal G. A fast method for high-quality genomic DNA extraction from whole human blood. BioTechnique 1991;11:298
  17. Boerwinkle E, Xiong W, Fourest E, Chan L. Rapid typing of tandemly repeated hypervariable loci by the polymerase chain reaction: application to the apolipoprotein B 3′hypervariable region. Genetics. 1989;86:212–216
  18. Wu S, Seino S, Bell GI. Human collagen, type II, alpha 1 (Col2A1) gene: VNTR polymorphism detected by gene amplification. Nucleic Acids Res. 1990;18:3102–3103
  19. Horn GT, Richards B, Klinger KW. Amplification of a highly polymorphic VNTR segment by the polymerase chain reaction. Nucleic Acids Res. 1989;17:2140
  20. Kasai K, Nakamura Y, White R. Amplification of a variable number of tandem repats (VNTR) locus (pMCT118) by the polymerase chain reaction (PCR) and its application to forensic science. J. Forensic Sci. 1990;35:1196
  21. Decorte R, Cuppens H, Marynen P, Cassiman JJ. Rapid detection of hypervariable regions by the polymerase chain reaction technique. DNA. Cell Biol. 1990;9:461
  22. Nakahori I, Hamano K, Iwaya M, Nakagome Y. Sex identification by polymerase chain reaction using X–Y homologous primer. Am. J. Med. Gen. 1991;39:472
  23. Lo Y-MD, Wanscoat JS, Gillmer MDG, Patel P, Sampietro M, Fleming KA. Prenatal sex determination by DNA amplification from maternal peripheral blood. Lancet. 1989;9:1363
  24. Ramı́rez M, Dı́az MA, Garcı́a-Sánchez F, Velasco M, Casado F, Villa M, et al. Chimerism after allogeneic hematopoietic cell transplantation in childhood acute lymphoblastic leukemia. Bone Marrow Transplant. 1996;18:1161
  25. Helg C, Roux E, Beris P, Cabrol C, Wacker P, Darbellay R, et al. Adoptive immunotherapy for recurrent CML after BMT. Bone Marrow Transplant. 1993;12:125
  26. Helg C, Starobinski M, Jeannet M, Chapuis B. Donor lymphocyte infusion for the treatment of relapse after allogeneic hematopoietic stem cell transplantation. Leuk. Lymph. 1998;29:301
  27. Verdonck LF, Petersen EJ, Lokhorst HM, Nieuwenhuis HK, Dekker AW, Tilanus MGJ, et al. Donor leukocyte infusions for recurrent hematologic malignancies after allogeneic bone marrow transplantation: impact of infused and residual donor T-cells. Bone Marrow Transplant. 1998;22:1057
  28. Kolb HJ, Schattenberg A, Goldman JM, Hartenstein B, Jacobsen N, Arcese W, Ljungman P, Ferrant A, Verdonck L, Niederwieser D, van Rheo F, Mittermueller J, de Witte T, Holler E, Ansari H for the European Group for Blood and Marrow Transplantation Working Party Chronic Leukemia. Graft-versus leukemia effect of donor lymphocyte infusion in marrow grafted patients. Blood 1995;86:2041
  29. Román J, Martı́n C, Torres A, Garcı́a A, Andrés P, Garcı́a MJ, et al. Importance of mixed chimerism to predict relapse in persistently BCR/ABL positive long term survivors after allogeneic bone marrow transplantation for chronic myeloid leukemia. Leuk. Lymph. 1998;28:541
  30. Gardiner N, Lawrer M, O’Riordian J, DeArce M, Humphries P, McCann SR. Persistent donor chimaerism is consistent with disease free survival following BMT for chronic myeloid leukemia. Bone Marrow Transplant. 1997;20:235
  31. van Rhee F, Lin F, Cullis JO, Spencer A, Cross NC, Chase A, et al. Relapse of chronic myeloid leukemia after allogeneic bone marrow transplant: the case for giving donor leukocyte transfusions before the onset of hematologic relapse. Blood. 1994;83:3377
  32. Rapanotti MC, Arcese W, Buffolino, Iori AP, Mengarelli A, De Cuia MR, Cardillo A, Cimino G. Sequential monitoring of chimerism in chronic myeloid leukemia patients receiving donor lymphocyte transfusion for relapse after bone marrow transplantation. Bone Marrow Transplant 1997;19:703

PII: S0145-2126(99)00185-X

Leukemia Research
Volume 24, Issue 4 , Pages 339-347 , April 2000