Leukemia Research
Volume 23, Issue 8 , Pages 723-729 , August 1999

Megakaryocyte induced fibroblast proliferation is enhanced by costimulation with IL-6/IL-3 and dependent on secretory and adhesion events

Received 10 December 1998 ,Accepted 23 March 1999.

References 

  1. Kittler ELW, McGrath H, Temeless D, Crittenden RB, Kister VK, Quesenberry J. Biologic significance of constitutive and subliminal growth factor production by bone marrow stroma. Blood. 1992;79:3168
  2. Rohde D, Wickenhauser C, Denecke S, Stach A, Lorenzen J, Hansmann ML, et al. Cytokine release by bone marrow cells: analysis at the single cell level. Virchows. Archiv. 1994;424:389
  3. Wickenhauser C, Lorenzen J, Thiele J, Hillienhof A, Jungheim K, Schmitz B, et al. Secretion of cytokines (IL-1α, -3, and -6 and granulocyte-macrophage colony-stimulating factor) by normal human bone marrow megakaryocytes. Blood. 1995;85:685
  4. Metcalf D. Hematopoietic regulators: redundancy or subtlety?. Blood. 1993;82:3515
  5. Olsson I, Gullberg U, Lantz M, Richter J. The receptors for regulatory molecules of hematopoiesis. Eur. J. Haematol. 1992;48:1
  6. Hawley RG. Hematopathology of interleukin 6-type cytokines. Stem. Cells. 1994;12:155
  7. Kishimoto T. The biology of interleukin-6. Blood. 1989;74:1
  8. Kishimoto T, Toya T, Akira S. Cytokine signal transduction. Cell. 1994;76:253
  9. Hoffmann R. Regulation of megakaryopoiesis. Blood. 1989;74:1196
  10. Kauskansky K. Thrombopoietin: the primary regulator of platelet production. Blood. 1995;86:419
  11. Debili N, Massé JM, Katz A, Guichard J, Breton-Gorius J, Vainchenker W. Effects of the recombinant hematopoietic growth factors interleukin-3, interleukin-6, stem cell factor, and leukemia inhibitory factor on the megakaryocytic differentiation of CD34+ cells. Blood. 1993;82:84
  12. Navarro S, Debili N, Le Couedic JP, Klein B, Breton-Gorius J, Doly J, et al. Interleukin-6 and its receptor are expressed by human megakaryocytes: in vitro effects on proliferation and endoreplication. Blood. 1991;77:461
  13. Fuse A, Kakuda H, Shima Y, van Damme J, Billiau A, Sato T. Interleukin 6, a possible autocrine growth and differentiation factor for the human megakaryocytic cell line, CMK. Br. J. Haematol. 1991;77:32
  14. Avraham H, Vannier E, Chi SY, Dinarello CA, Groopman JE. Cytokine gene expression and synthesis by human megakaryocytes. Int. J. Cell. Cloning. 1992;10:70
  15. Chen ZY, Gu XF, Caen JP, Han ZC. Interleukin-3 is an autocrine growth factor of human megakaryocytes, the DAMI and the MEG-01 cells. Br. J. Haematol. 1994;88:481
  16. Wickenhauser C, Hillienhof A, Jungheim C, Lorenzen J, Ruskowski H, Hansmann ML, et al. Detection and quantification of transforming growth factor ( and platelet-derived growth factor release by normal human megakaryocytes. Leukemia. 1995;9:310
  17. Castro-Malaspina H, Rabellino EM, Yen A, Nachman RL, Moore MAS. Human megakaryocyte stimulation of bone marrow fibroblasts. Blood. 1981;57:781
  18. Schmitz B, Thiele J, Kaufmann R, Witte O, Wickenhauser C, Kuhn-Regnier F, et al. Megakaryocytes and fibroblasts-interactions determined in normal human bone marrow specimens. Leuk. Res. 1995;19:629
  19. Schmitz B, Thiele J, Witte O, Kaufmann R, Wickenhauser C, Fischer R. Influence of cytokines (IL-1α, IL-3, IL-11, GM-CSF) on megakaryocyte-fibroblast interactions in normal human bone marrow. Eur. J. Haematol. 1995;55:24
  20. Schmitz B, Thiele J, Otto F, Theile-Ochel S, Heedt T, Zensen U, et al. Interactions between endogeneous lectins and fucosylated oligosaccharids in megakaryocyte-dependent fibroblast growth of the normal bone marrow. Leukemia. 1996;10:1604
  21. Schmitz B, Thiele J, Otto F, Farahmand P, Henze F, Frimpong S, et al. Evidence for integrin receptor involvement in megakaryocyte-fibroblast interaction-a possible pathomechanism for the evolution of myelofibrosis. J. Cell Physiol.; 176. 1998;1998:445
  22. Martyré MC, Romquin N, Bousse-Kerdiles MC, Chewillard S, Benyahia B, Dupriez B, et al. Transforming growth factor-β and megakaryocytes in the pathogenesis of idiopathic myelofibrosis. Br. J. Haematol. 1994;88:9
  23. Martyré MC. TGF-β and megakaryocytes in the pathogenesis of myelofibrosis in myeloproliferative disorders. Leuk. Lymph. 1995;20:39
  24. Michiel DF, Oppenheim JJ. Cytokines as positive and negative regulators of tumor promotion and progression. Semin. Cancer. Biol. 1992;3:3
  25. Puztai L, Lewis CE, Lorenzen J, O′D McGee J. Growth factors: regulation of normal and neoplastic growth. J. Pathol. 1993;169:191
  26. Schmitz B, Radbruch A, Kümmel T, Wickenhauser C, Korb H, Hansmann ML, et al. Magnetic activated cell sorting (MACS)-a new immunological method for megakaryocytic cell isolation: comparison of different separation techniques. Eur. J. Haematol. 1994;52:267
  27. Gatter KC, Cordell JL, Turley H, Heryet A, Kieffer N, Anstee DJ, et al. The immunohistological detection of platelets, megakaryocytes and thrombi in routinely processed specimens. Histopathology. 1988;13:257
  28. Debili N, Issaad C, Masse JM, Giuchard I, Katz A, Breton-Gorius J, et al. Expression of CD34 and platelet glycoproteins during human megakaryocytic differentiation. Blood. 1992;80:3022
  29. Schmitz B, Park IA, Kaufmann R, Thiele J, Fischer R. Influence of cytokine stimulation (granulocyte macrophage-colony stimulating factor, interleukin-3, and transforming growth factor-beta-1) on adhesion molecule expression in normal human bone marrow fibroblasts. Acta Haematol. Basel. 1995;94:173
  30. Tomer A, Harker LA, Burstein SA. Purification of human megakaryocytes by fluorescence-activated cell sorting. Blood. 1987;70:1735
  31. Briddell RA, Brandt JE, Leemhuis TB, Hoffman R. Role of cytokines in sustaining long-term human megakaryopoiesis in vitro. Blood. 1992;79:332
  32. Lemoli RM, Gulati SC. Effect of stem cell factor (c-kit ligand), granulocyte-macrophage colony stimulating factor and interleukin 3 on hematopoietic progenitors in human long-term bone marrow cultures. Stem. Cells. 1993;11:435
  33. Ishibashi T, Kimura H, Uchida T, Kariyone S, Friese P, Burstein SA. Human interleukin 6 is a direct promotor of maturation of megakaryocytes in vitro. Proc. Natl. Acad. Sci. USA. 1989;86:5953
  34. Bruno E, Hoffman R. Effect of interleukin 6 on in vitro human megakaryopoiesis: its interaction with other cytokines. Exp. Hematol. 1989;17:1038
  35. Bruno E, Cooper RJ, Briddell RA, Hoffman R. Further examination of the effects of recombinant cytokines on the proliferation of human megakaryocyte progenitor cells. Blood. 1991;77:2339
  36. Ikebushi K, Wong GG, Clark SC, Ihle JN, Hirai T, Ogawa M. Interleukin 6 enhancement of interleukin 3-dependent proliferation of multipotent hemopoietic progenitors. Proc. Natl. Acad. Sci. USA. 1987;84:9035
  37. Koike K, Nakahata T, Tagaki M, Kobayashi T, Ishigura A, Tsuji K, et al. Synergism of BSF-2/interleukin 6 and interleukin 3 on development of multipotential hemopoietic progenitors in serum-free culture. J. Exp. Med. 1988;168:879–890
  38. Avraham H, Banu N, Scadden DT, Abraham J, Groopman JE. Modulation of egakaryopoiesis by human basic fibroblast growth factor. Blood. 1994;83:2126
  39. Bruno E, Cooper RJ, Wilson EL, Gabrilove JL, Hoffman R. Basic fibroblast growth factor promotes the proliferation of human megakaryocyte progenitor cells. Blood. 1993;82:430
  40. Guba SC, Sartor CI, Gottschalk LR, Ye-Hu J, Mulligan T, Emerson SG. Bone marrow stromal fibroblasts secrete interleukin-6 and granulocyte-macrophage colony-stimulating factor in the absence of inflammatory stimulation: demonstration by serum-free bioassay, enzyme-linked immunosorbent assay, and reverse transcriptase polymerase chain reaction. Blood. 1992;80:1190
  41. Bikfalvi A, Han ZC, Fuhrmann G. Interaction of fibroblast growth factor (FGF) with megakaryocytopoiesis and demonstration of FGF receptor expression in megakaryocytic-like cells. Blood. 1992;80:1905
  42. Ignatz RA, Massagué J. Cell adhesion protein receptors as targets for transforming growth factor-β action. Cell. 1987;51:189
  43. Kinashi T, Springer TA. Regulation of cell-matrix adhesion by receptor tyrosine kinases. Leuk. Lymph. 1995;18:203
  44. Hardy CL, Minguell JJ. Modulation of the adhesion of hemapoietic progenitor cells to the RGD site of fibronectin by interleukin 3. J. Cell Physiol. 1995;164:315
  45. Avraham H, Cowley S, Chi SY, Jiang S, Groopman JE. Characterization of adhesive interactions between human endothelial cells and megakaryocytes. J. Clin. Invest. 1994;91:2378
  46. Bendall LJ, Kortlepel K, Gottlieb DJ. Bone marrow fibroblast exposure to the inflammatory cytokines tumor necrosis factor-α and interferon-γ increases adhesion of acute myeloid leukemia cells and alters the adhesive mechanism. Exp. Hematol. 1997;25:132
  47. Thiele J, Fischer R. Megakaryocytopoiesis in haematological disorders: diagnostic features of bone marrow biopsies. Virchows Archiv. A Pathol. Anat. 1991;418:81
  48. Ellis JT, Peterson P, Geller SA, Rappaport H. Studies of the bone marrow in polycythemia vera and the evolution of myelofibrosis and second hematologic malignancies. Semin. Hematol. 1986;23:144
  49. Bilgrami S, Greenberg BR. Polycythemia rubra vera. Semin. Oncol. 1995;22:307
  50. Reilly JT. Pathogenesis of idiopathic myelofibrosis: role of growth factors. J. Clin. Pathol. 1992;45:461
  51. Wickenhauser C., Thiele J., Lorenzen J., Schmitz B., Frimpong S., Schramm K., Neumann I., Zankovich R., Fischer R. Polycythemia vera megakaryocytes but not megakaryocytes from normal controls and patients with smokers polyglobuly spontaneously express IL-6 and IL-6R and secrete IL-6. Leukemia (in press)
  52. Wang JC, Chen C, Mora M. Blood thrombopoietin, IL-6 and IL-11 levels in patients with agnogenic myeloid leukemia. Leukemia. 1997;11:1827
  53. Kobayashi S, Teramura M, Hoshino S, Motoji T, Oshimi K, Mizoguchi H. Circulating megakaryocyte progenitors in myeloproliferative disorders are hypersensitive to interleukin-3. Br. J. Haematol. 1993;83:539
  54. Dai CH, Krantz SB, Dessypris EN, Means Jr RT, Horn ST, Gilbert HS. Polycythemia vera. II. Hypersenitivity of bone marrow erythroid, granulocyte-macrophage, and megakaryocyte progenitor cells to interleukin-3 and granulocyte-macrophage colony-stimulating factor. Blood. 1992;80:891
  55. Bhatia R, McGlave PB, Dewald GW, Blazar BR, Verfaillie CM. Abnormal function of the bone marrow microenvironment in chronic myelogeneous leukemia: role of malignant stromal macrophages. Blood. 1995;85:3636
  56. Schirmacher P, Peters M, Ciliberto G, Blessing M, Lotz J, Meyer zum Büschenfelde KH, et al. Hepatocellular hyperplasia, plasmacytoma formation, and extramedullary hematopoiesis in interleukin (IL)-6/ soluble IL-6 receptor double-transgenic mice. Am. J. Pathol. 1998;153:639

PII: S0145-2126(99)00091-0

Leukemia Research
Volume 23, Issue 8 , Pages 723-729 , August 1999

Article Tools

* Image Usage & Resolution