Leukemia Research
Volume 36, Issue 6 , Pages 720-726, June 2012

A comprehensive cytogenetic classification of 1466 Chinese patients with de novo acute lymphoblastic leukemia

Center for Stem Cell, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

Received 11 October 2011; received in revised form 11 December 2011; accepted 17 December 2011. published online 20 January 2012.

Abstract 

Cytogenetics and molecular cytogenetics of 1466 Chinese patients with de novo acute lymphoblastic leukemia (ALL) were studied. Cytogenetic results were available in 1175 patients. Cross-correlations of 23 subclasses of cytogenetic abnormalities were described. Childhood cases had higher incidences of normal karyotype, t(1;19), +8, 12q−, +21, +22 and high hyperdiploidy with 51–65 chromosomes, and lower incidences of t(9;22) and −5/5q− than adult ones (all p<0.05). Relationships of cytogenetic subclasses with immunophenotyping subgroups of ALL were studied. Our study presents the cytogenetic characteristics of a large series of Chinese ALL patients.

Keywords: Acute lymphoblastic leukemia, Additional cytogenetic abnormalities, Chromosomal abnormalities, Cytogenetic abnormalities, Cytogenetics, Molecular cytogenetics

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PII: S0145-2126(11)00607-2

doi:10.1016/j.leukres.2011.12.016

Leukemia Research
Volume 36, Issue 6 , Pages 720-726, June 2012

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