Differential MiRNA expression in childhood acute lymphoblastic leukemia and association with clinical and biological features

de Oliveira, Jaqueline Carvalho; Scrideli, Carlos Alberto; Brassesco, María Sol; Morales, Andressa Gois; Pezuk, Julia Alejandra; Queiroz, Rosane de Paula; Yunes, José Andres; Brandalise, Silvia Regina; Tone, Luiz Gonzaga

doi:10.1016/j.leukres.2011.10.005

« Previous Next »Leukemia Research
Volume 36, Issue 3 , Pages 293-298, March 2012

Differential MiRNA expression in childhood acute lymphoblastic leukemia and association with clinical and biological features

Jaqueline Carvalho de Oliveira
- Department of Genetics, Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil
Carlos Alberto Scrideli
- Department of Paediatrics, Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil
- Corresponding author at: Department of Paediatrics, Medicine of Ribeirão Preto, University of São Paulo, Avenida Bandeirantes 3900, 14049-900, Ribeirão Preto, São Paulo, Brazil. Tel.: +55 16 3602 2672; fax: +55 16 3602 2700.
María Sol Brassesco
- Department of Paediatrics, Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil
Andressa Gois Morales
- Department of Genetics, Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil
Julia Alejandra Pezuk
- Department of Genetics, Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil
Rosane de Paula Queiroz
- Department of Paediatrics, Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil
José Andres Yunes
- Centro Infantil Boldrini, Campinas, São Paulo, Brazil
- Department of Paediatrics, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil
Silvia Regina Brandalise
- Centro Infantil Boldrini, Campinas, São Paulo, Brazil
- Department of Paediatrics, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil
Luiz Gonzaga Tone
- Department of Genetics, Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil
- Department of Paediatrics, Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil

Received 31 May 2011; received in revised form 27 August 2011; accepted 7 October 2011. published online 18 November 2011.

Abstract

The present study aimed to analyze the expression profile of the microRNAs previously described as associated with childhood ALL, miR-92a, miR-100, miR-125a-5p, miR-128a, miR-181b, miR-196b and let-7e, and their association with biological/prognostic features in 128 consecutive samples of childhood acute lymphoblastic leukemia (ALL) by quantitative real-time PCR. A significant association was observed between higher expression levels of miR-196b and T-ALL, miR-100 and patients with low white blood cell count at diagnosis and t(12;21) positive ALL. These findings suggest a potential activity of these microRNAs in pediatric ALL biology.

Keywords: MicroRNA, Pediatric acute lymphoblastic leukemia, Prognostic features