Genome-wide association study of childhood acute lymphoblastic leukemia in Korea

Han, Sohee; Lee, Kyoung-Mu; Park, Sue K.; Lee, Jong Eun; Ahn, Hyo Seop; Shin, Hee Young; Kang, Hyoung Jin; Koo, Hong Hoe; Seo, Jong Jin; Choi, Ji Eun; Ahn, Yoon-Ok; Kang, Daehee

doi:10.1016/j.leukres.2010.02.001

« Previous Next »Leukemia Research
Volume 34, Issue 10 , Pages 1271-1274, October 2010

Genome-wide association study of childhood acute lymphoblastic leukemia in Korea

Sohee Han
- Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
Kyoung-Mu Lee
- Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
- Clinical Research Institute, Seoul National University Hospital, Seoul, Republic of Korea
Sue K. Park
- Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
- Institute of Health Politics and Management, Seoul National University, Seoul, Republic of Korea
- Cancer Research Institute, Seoul National University, Seoul, Republic of Korea
Jong Eun Lee
- DNA Link Inc. Seoul, Republic of Korea
Hyo Seop Ahn
- Department of Pediatrics, Seoul National University College of Medicine, Seoul, Republic of Korea
- Cancer Research Institute, Seoul National University, Seoul, Republic of Korea
Hee Young Shin
- Department of Pediatrics, Seoul National University College of Medicine, Seoul, Republic of Korea
- Cancer Research Institute, Seoul National University, Seoul, Republic of Korea
Hyoung Jin Kang
- Department of Pediatrics, Seoul National University College of Medicine, Seoul, Republic of Korea
- Cancer Research Institute, Seoul National University, Seoul, Republic of Korea
Hong Hoe Koo
- Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
- Cancer Research Institute, Seoul National University, Seoul, Republic of Korea
Jong Jin Seo
- Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
Ji Eun Choi
- Department of Pediatrics, Seoul Metropolitan Boramae Hospital, Seoul, Republic of Korea
Yoon-Ok Ahn
- Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
Daehee Kang
- Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
- Cancer Research Institute, Seoul National University, Seoul, Republic of Korea
- Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology and College of Medicine or College of Pharmacy, Seoul National University, Seoul, Republic of Korea
- Corresponding author at: Department of Preventive Medicine, Seoul National University College of Medicine, 103 Yongon (Daehangno), Jongno-gu, Seoul, 110-799, Republic of Korea. Tel.: +82 2 740 8326; fax: +82 2 747 4830.

Received 16 November 2009; received in revised form 20 January 2010; accepted 1 February 2010. published online 07 March 2011.

Abstract

We conducted a genome-wide association study of childhood acute lymphoblastic leukemia (ALL) in a case–control study conducted in Korea. Incident childhood ALL cases (n=50) and non-cancer controls (n=50) frequency-matched to cases by age and sex, recruited from three teaching hospitals in Seoul between 2003 and 2008, were genotyped using Affymetrix SNP Array 6.0 platform. ALL risks were estimated as odds ratios (ORs) and 95% confidence intervals (CIs) adjusted for age and birth weight. The false discovery rate (FDR) was used for adjusting multiple tests. Of these 1 million SNPs, six SNPs in 4 genes (HAO1 rs6140264, EPB41L2 rs9388856, rs9388857, rs1360756, C2orf3 12105972, MAN2A1 rs3776932) were strongly associated with childhood ALL risk (P_dominant≤0.0001 and P_trend<0.006). These SNPs remained significant after FDR adjustment (FDR value <0.2). Our genome-wide association study in Korea children identified a few genetic variations as potential susceptibility markers for ALL, warranting further replication studies among various ethnic groups.