Leukemia Research
Volume 34, Issue 4 , Pages 426-429 , April 2010

Genetic inactivation of Ikaros is a rare event in human T-ALL

  • Ambroise Marçais

      Affiliations

    • Department of Cancer Biology, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Illkirch, France
    • Inserm U964, Illkirch, France
    • CNRS UMR7104, Illkirch, France
    • Université de Strasbourg, Strasbourg, France
    • ,
  • Robin Jeannet

      Affiliations

    • Department of Cancer Biology, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Illkirch, France
    • Inserm U964, Illkirch, France
    • CNRS UMR7104, Illkirch, France
    • Université de Strasbourg, Strasbourg, France
    • ,
  • Lucie Hernandez

      Affiliations

    • Genome Rearrangements and Cancer Group, Institut National de la Santé et de la Recherche Médicale U728 and Institut Universitaire d’Hématologie, Paris 7 University, Hôpital Saint-Louis, Paris, France
    • ,
  • Jean Soulier

      Affiliations

    • Genome Rearrangements and Cancer Group, Institut National de la Santé et de la Recherche Médicale U728 and Institut Universitaire d’Hématologie, Paris 7 University, Hôpital Saint-Louis, Paris, France
    • ,
  • François Sigaux

      Affiliations

    • Genome Rearrangements and Cancer Group, Institut National de la Santé et de la Recherche Médicale U728 and Institut Universitaire d’Hématologie, Paris 7 University, Hôpital Saint-Louis, Paris, France
    • ,
  • Susan Chan

      Affiliations

    • Department of Cancer Biology, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Illkirch, France
    • Inserm U964, Illkirch, France
    • CNRS UMR7104, Illkirch, France
    • Université de Strasbourg, Strasbourg, France
    • ,
  • Philippe Kastner

      Affiliations

    • Department of Cancer Biology, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Illkirch, France
    • Inserm U964, Illkirch, France
    • CNRS UMR7104, Illkirch, France
    • Université de Strasbourg, Strasbourg, France
    • Corresponding Author InformationCorresponding author at: Department of Cancer Biology, Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), BP 10142, 67404 Illkirch Cedex, France. Tel.: +33 3 88 65 34 72; fax: +33 3 88 65 32 01.

Received 23 July 2009 ,Revised 8 September 2009 ,Accepted 9 September 2009.

References 

  1. Mullighan CG, Miller CB, Radtke I, Phillips LA, Dalton J, Ma J, et al. BCR-ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros. Nature. 2008;453:110–114
  2. Dumortier A, Jeannet R, Kirstetter P, Kleinmann E, Sellars M, dos Santos NR, et al. Notch activation is an early and critical event during T-cell leukemogenesis in Ikaros-deficient mice. Mol Cell Biol. 2006;26:209–220
  3. López-Nieva P, Santos J, Fernández-Piqueras J. Defective expression of Notch1 and Notch2 in connection to alterations of c-Myc and Ikaros in gamma-radiation-induced mouse thymic lymphomas. Carcinogenesis. 2004;25:1299–1304
  4. Sun L, Crotty ML, Sensel M, Sather H, Navara C, Nachman J, et al. Expression of dominant-negative Ikaros isoforms in T-cell acute lymphoblastic leukemia. Clin Cancer Res. 1999;5:2112–2120
  5. Nakase K, Ishimaru F, Avitahl N, Dansako H, Matsuo K, Fujii K, et al. Dominant negative isoform of the Ikaros gene in patients with adult B-cell acute lymphoblastic leukemia. Cancer Res. 2000;60:4062–4065
  6. Ruiz A, Jiang J, Kempski H, Brady HJ. Overexpression of the Ikaros 6 isoform is restricted to t(4;11) acute lymphoblastic leukaemia in children and infants and has a role in B-cell survival. Br J Haematol. 2004;125:31–37
  7. Maser RS, Choudhury B, Campbell PJ, Feng B, Wong KK, Protopopov A, et al. Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers. Nature. 2007;447:966–971
  8. Kuiper RP, Schoenmakers EF, van Reijmersdal SV, Hehir-Kwa JY, van Kessel AG, van Leeuwen FN, et al. High-resolution genomic profiling of childhood ALL reveals novel recurrent genetic lesions affecting pathways involved in lymphocyte differentiation and cell cycle progression. Leukemia. 2007;21:1258–1266
  9. Soulier J, Clappier E, Cayuela JM, Regnault A, García-Peydró M, Dombret H, et al. HOXA genes are included in genetic and biologic networks defining human acute T-cell leukemia (T-ALL). Blood. 2005;106:274–286
  10. Greif PA, Tizazu B, Krause A, Kremmer E, Bohlander SK. The leukemogenic CALM/AF10 fusion protein alters the subcellular localization of the lymphoid regulator Ikaros. Oncogene. 2008;27:2886–2896
  11. Clappier E, Cuccuini W, Cayuela JM, Vecchione D, Baruchel A, Dombret H, et al. Cyclin D2 dysregulation by chromosomal translocations to TCR loci in T-cell acute lymphoblastic leukemias. Leukemia. 2006;20:82–86
  12. Clappier E, Cuccuini W, Kalota A, Crinquette A, Cayuela JM, Dik WA, et al. The C-MYB locus is involved in chromosomal translocation and genomic duplications in human T-cell acute leukemia (T-ALL), the translocation defining a new T-ALL subtype in very young children. Blood. 2007;110:1251–1261

PII: S0145-2126(09)00472-X

doi: 10.1016/j.leukres.2009.09.012

Leukemia Research
Volume 34, Issue 4 , Pages 426-429 , April 2010

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