Leukemia Research
Volume 34, Issue 4 , Pages 463-470 , April 2010

Elevated mRNA level of hST6Gal I and hST3Gal V positively correlates with the high risk of pediatric acute leukemia

  • Susmita Mondal

      Affiliations

    • Infectious Diseases and Immunology Division, Indian Institute of Chemical Biology, An Unit of Council of Scientific and Industrial Research, Govt. of India, 4, Raja S.C. Mullick Road, Kolkata 700032, India
    • ,
  • Sarmila Chandra

      Affiliations

    • Kothari Medical Centre, Kolkata, India
    • ,
  • Chitra Mandal

      Affiliations

    • Infectious Diseases and Immunology Division, Indian Institute of Chemical Biology, An Unit of Council of Scientific and Industrial Research, Govt. of India, 4, Raja S.C. Mullick Road, Kolkata 700032, India
    • Corresponding Author InformationCorresponding author. Tel.: +91 33 2429 8861; fax: +91 33 2473 5197.

Received 25 April 2009 ,Revised 25 July 2009 ,Accepted 27 July 2009.

References 

  1. Schauer R. Achievements and challenges of sialic acid research. Glycoconj J. 2000;17:485–499
  2. Crocker PR, Varki A. Siglecs, sialic acids and innate immunity. Trends Immunol. 2001;22:337–342(review)
  3. Colin-Huges R. Galectins as modulators of cell adhesion. Biochimie. 2001;83:667–676
  4. Basu S, Basu M, Basu SS. Biological significance of sialyltransferases. In:  Rosenberg A editors. Biology of the sialic acids. New York: Plenum Press; 1995;p. 69–94
  5. Basu S, Basu M, Dastgheib S, Hawes JW. Biosynthesis and regulation of glycosphingolipids. In:  Barton D,  Nakanishi K,  Meth-Cohen O editor. Comprehensive natural products chemistry. vol. 3:New York: Pergamon Press; 1999;p. 107–128
  6. Aulson JC, Weinstein J, Schauer A. Tissue specific expression of sialyltransferase. J Biol Chem. 1989;264:10931–10934
  7. Yamamoto H, Satio T, Kaneko Y, Kersey D, Yong VW, Bremer EG, et al. Alpha 2,3 sialyltransferase mRNA and alpha 2,3-linked glycoproteins sialylation are increased in malignant gliomas. Brain Res. 1997;755:175–179
  8. Zhu Y, Srivatana U, Ullah A, Gagneja H, Berenson CS, Lance P. Suppression of a sialyltransferase by antisense DNA reduces invasiveness of human colon cancer cells in vitro. Biochim Biophys Acta. 2001;1536:148–160
  9. Wang PH, Li YF, Juang CM, Lee YR, Chao HT, Ng HT, et al. Altered mRNA expression of sialyltransferase in squamous cell carcinomas of the cervix. Gynecol Oncol. 2001;83:121–127
  10. Lepers AH, Ruiz VV, Recchi MAK, Peit BS, Julien S, Delannoy P. The human sialyltransferase family. Biochimie. 2001;83:727–737
  11. Dall’Olio F, Chiricolo M. Sialyltransferase in cancer. Glycoconj J. 2001;18:841–850
  12. Wang PH, Lee YR, Juang CM, Yang YH, Lo WH, Lai CR, et al. Altered mRNA expression of sialyltransferases in ovarian cancers. Gynecol Oncol. 2005;99:631–639
  13. Brockhausen I. Pathways of O-glycan biosynthesis in cancer cells. Biochim Biophys Acta. 1999;1473:67–95
  14. Chandrasekaran EV, Jain RK, Matta KL. Ovarian cancer alpha1,3-lfucosyltransferase. J Biol Chem. 1992;267:23806–23814
  15. Thompson S, Cantwell BM, Matta KL, Turner GA. Parallel changes in the blood levels of abnormally-fucosylated haptoglobin and alpha1,3 fucosyltransferase in relation to tumor burden: more evidence for a disturbance of fucose metabolism in cancer. Cancer Lett. 1992;65:115–121
  16. Wang PH, Li YF, Juang CM, Lee YR, Chao HT, Ng HT, et al. Expression of sialyltransferase family members in cervical squamous cell carcinoma correlates with lymph node metastases. Gynecol Oncol. 2002;86:45–52
  17. Mandal C, Chatterjee M, Sinha D. Investigation of 9-O-acetylated sialoglycoconjugates in childhood acute lymphoblastic leukemia. Br J Haematol. 2000;110:801–812
  18. Sinha D, Chatterjee M, Mandal C. O-Acetylated sialic acids—their detection, biological significance and alteration in diseases. Trends Glycosci Glycotechnol. 2000;12:1–17
  19. Ghosh S, Bandyopadhyay S, Mukherjee K, Mallick A, Pal S, Mandal C, et al. O-Acetylation of sialic acids is required for the survival of lymphoblasts in childhood acute lymphoblastic leukemia (ALL). Glycoconj J. 2007;24:17–24
  20. Mukherjee K, Chava AK, Mandal C, Dey SN, Kniep B, Chandra S, et al. O-Acetylation of GD3 prevents its apoptotic effect and promotes survival of lymphoblasts in childhood acute lymphoblastic leukaemia. J Cell Biochem. 2008;105:724–734
  21. Mandal C, Srinivasan GV, Chowdhury S, Chandra S, Mandal C, Schauer R, et al. High level of sialate-O-acetyltransferase activity in lymphoblasts of childhood acute lymphoblastic leukaemia (ALL): enzyme characterization and correlation with disease status. Glycoconj J. 2009;26:57–73
  22. Mandal C, Tringali C, Mondal S, Anastasia L, Chandra S, Venerando B, et al. Down regulation of membrane-bound Neu3 constitutes a new potential marker for childhood lymphoblastic leukemia and induces apoptosis suppression of neoplastic cells. Int J Cancer. 2009;(July):[Epub ahead of print]
  23. Sinha D, Mandal C, Bhattacharya DK. Identification of 9-Oacetylated sialoglycoconjugates (9-OAcSGs) as biomarkers in childhood acute lymphoblastic leukemia using a lectin, AchatininH, as a probe. Leukemia. 1999;13:119–125
  24. Pal S, Ghosh S, Bandhyopadhyay S, Mandal C, Bandhyopadhyay S, Bhattacharya DK, et al. Differential expression of 9-O-acetylated sialoglycoconjugates on leukemic blasts: a potential tool for long-term monitoring of children with acute lymphoblastic leukaemia. Int J Cancer. 2004;111:270–277
  25. Pal S, Ghosh S, Mandal C, Kohla G, Brossmer R, Isecke R, et al. Purification and characterization of 9-O-acetylated sialoglycoproteins from leukemic cells and their potential tool as immunological tool for monitoring childhood acute lymphoblastic leukaemia. Glycobiology. 2004;14:859–870
  26. Pui CH, Robison LL, Look AT. Acute lymphoblastic leukaemia. Lancet. 2008;371:1030–1043
  27. Pui CH, Campana D, Evans WE. Childhood acute lymphoblastic leukaemia: current status and future perspective. Lancet Oncol. 2001;2:597–607
  28. Greaves MF, Mizutani S, Furlay AJ, Sutherland DR, Chan LC, Ford AM, et al. Differentiation-linked gene rearrangement and expression in acute lymphoblastic leukaemia. Clin Haematol. 1986;15:621–639
  29. Pui CH, Boyett JM, Relling MV, Harrison PL, Rivera GK, Behm FG, et al. Sex differences in prognosis for children with acute lymphoblastic leukemia. J Clin Oncol. 1999;17:818–824
  30. Chessells JM, Richards SM, Bailey CC, Lilleyman JS, Eden OB. Gender and treatment outcome in childhood lymphoblastic leukaemia: report from the MRC UKALL trials. Br J Haematol. 1995;89:364–372
  31. Tringali C, Lupo B, Anastasia L, Papini N, Monti E, Bresciani R, et al. Expression of sialidase Neu2 in leukemic K562 cells induces apoptosis by impairing Bcr-Abl/Src kinases signaling. J Biol Chem. 2007;282:14364–14372
  32. Tringali C, Lupo B, Cirillo F, Papini N, Anastasia L, Lamorte G, et al. Silencing of membrane-associated sialidase Neu3 diminishes apoptosis resistance and triggers megakaryocytic differentiation of chronic myeloid leukemic cells K562 through the increase of ganglioside GM3. Cell Death Differ. 2009;16:164–174
  33. Tucci F, Aricò M. Treatment of pediatric acute lymphoblastic leukaemia. Haematologica. 2008;93:1124–1128
  34. Chandy M. Childhood acute lymphoblastic leukemia in India: an approach to management in a three-tier society. Med Pediatr Oncol. 1995;25:197–203
  35. Recchi MA, Hebbar M, Hornez L, Harduin-Lepers A, Peyrat JP, Delannoy P. Multiplex reverse transcription polymerase chain reaction assessment of sialyltransferase expression in human breast cancer. Cancer Res. 1998;58:4066–4070
  36. Weinstein J, Lee EU, Mcentee K, Lai PH, Paulson JC. Primary structure of β-galactoside α2,6-sialyltransferase. Conversion of membrane-bound enzyme to soluble forms by cleavage of the NH2-terminal signal anchor. J Biol Chem. 1987;262:17735–17743
  37. Dall’Olio FD, Chiricolo M, Lau JTY. Differential expression of the hepatic transcript of β-galactoside α2,6 sialyltransferase in human colon cancer cell lines. Int J Cancer. 1999;81:243–247
  38. Pousset D, Piller V, Bureaud N, Monsigny M, Piller F. Increased alpha-2,6 sialylation of N-glycans in a transgenic mouse model of hepatocellular carcinoma. Cancer Res. 1997;57:4249–4256
  39. Taniguchi A, Higai K, Hasegawa Y, Utsumi K, Matsumoto K. Differentiation elicits negative regulation of human β-galactoside α2,6-sialyltransferase at the mRNA level in the HL-60 cell line. FEBS Lett. 1998;441:191–194
  40. Taniguchi A, Hasegawa Y, Higai K, Matsumoto K. Transcriptional regulation of human β-galactoside α2,6-sialyltransferase (hST6Gal I) gene during differentiation of the HL-60 cell line. Glycobiology. 2000;10:623–628
  41. Hakomori S. Aberrant glycosylation in tumors and tumor-associated carbohydrate antigens. Adv Cancer Res. 1989;52:257–331
  42. Yogeeswaran G, Stein BS, Sebastian H. Altered cell surface organization of gangliosides and sialylglycoproteins of mouse metastatic melanoma variant lines selected in vivo for enhanced lung implantation. Cancer Res. 1978;385:1336–1344
  43. Nozue M, Sakiyama H, Tsuchiya K, Hirabayashi Y, Taniguchi M. Melanoma antigen expression and metastatic ability of mutant B16 melanoma clones. Int J Cancer. 1988;425:734–738
  44. Watanabe R, Ohyama C, Aoki H, Takahashi T, Satoh M, Saito S, et al. Ganglioside GM3 overexpression induces apoptosis and reduces malignant potential in murine bladder cancer. Cancer Res. 2002;62:3850–3854
  45. Thampoe IJ, Furukawa K, Vellvé E, Lloyd KO. Sialyltransferase levels and ganglioside expression in melanoma and other cultured human cancer cells. Cancer Res. 1989;49:6258–6264
  46. Ye JN, Gu TG, Xia LA, Murphy MJ, Lee W, Gao NH, et al. Enhanced expression of ganglioside GD3 in human and rat hepatocellular carcinoma cells and NIH 3T3 cells transfected with human tumor DNAs. Cancer Res. 1990;50:7697–7702
  47. Yamashiro S, Okada M, Haraguchi M, Furukawa K, Lloyd KO, Shiku H, et al. Expression of alpha 2,8-sialyltransferase (GD3 synthase) gene in human cancer cell lines: high level expression in melanomas and up-regulation in activated T lymphocytes. Glycoconj J. 1995;12:894–900
  48. Gornati R, Basu S, Montorfano G, Berra B. Glycosyltransferase activities in human meningiomas. Preliminary results. Cancer Biochem Biophys. 1995;15:1–10
  49. Osanai T, Watanabe Y, Sanai Y. Glycolipid sialyltransferases are enhanced during neural differentiation of mouse embryonic carcinoma cells, P19. Biochem Biophys Res Commun. 1997;241:327–333
  50. Koh Y, Tsunoda T, Iwahashi M, Yamaue H, Ishimoto K, Tanimura H, et al. Decreased expression of α2,8 sialyltransferase and increased expression of β1,4 N-acetylgalactosaminyltransferase in gastrointestinal cancers. Exp Biol Med. 2002;227:196–200
  51. Monti E, Preti A, Venerando B, Borsani G. Recent development in mammalian sialidase molecular biology. Neurochem Res. 2002;27:649–663(review)

PII: S0145-2126(09)00389-0

doi: 10.1016/j.leukres.2009.07.042

Leukemia Research
Volume 34, Issue 4 , Pages 463-470 , April 2010

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