High incidence of chronic lymphocytic leukemia (CLL) diagnosed by immunophenotyping: A population-based Canadian cohort

Seftel, M.D.; Demers, A.A.; Banerji, V.; Gibson, S.B.; Morales, C.; Musto, G.; Pitz, M.W.; Johnston, J.B.

doi:10.1016/j.leukres.2009.06.013

« Previous Next »Leukemia Research
Volume 33, Issue 11 , Pages 1463-1468, November 2009

High incidence of chronic lymphocytic leukemia (CLL) diagnosed by immunophenotyping: A population-based Canadian cohort

M.D. Seftel
- Section of Haematology/Oncology, Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
- Corresponding author at: Department of Medical Oncology and Haematology, CancerCare Manitoba, ON 2081, 675 Mcdermot Avenue, Winnipeg, MB, R3E0V9, Canada. Tel.: +1 204 787 3594; fax: +1 204 786 0196.
A.A. Demers
- Department of Community Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada
- Epidemiology and Cancer Registry, CancerCare Manitoba, Winnipeg, Manitoba, Canada
V. Banerji
- Section of Haematology/Oncology, Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
S.B. Gibson
- Manitoba Institute for Cell Biology, Winnipeg, Manitoba, Canada
C. Morales
- Department of Pathology, University of Manitoba, Winnipeg, Manitoba, Canada
G. Musto
- Epidemiology and Cancer Registry, CancerCare Manitoba, Winnipeg, Manitoba, Canada
M.W. Pitz
- Section of Haematology/Oncology, Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
J.B. Johnston
- Section of Haematology/Oncology, Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
- Manitoba Institute for Cell Biology, Winnipeg, Manitoba, Canada

Received 20 April 2009; received in revised form 9 June 2009; accepted 11 June 2009. published online 07 March 2011.

Abstract

Incidence and outcomes of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL) are not well established at the population level, especially since the widespread use of immunophenotyping. We studied the epidemiology of CLL in Manitoba (Canada) by combining data from a centralized flow cytometry facility and the provincial cancer registry for the period 1998–2003. Of 616 cases identified, 27% of patients identified by flow cytometry were not on the cancer registry. The age-adjusted incidence of 7.99/100,000 is substantially higher than the reported incidence in registry reports. We also noted differences in relative survival based on age and gender.

Keywords: Chronic lymphocytic leukemia, Small lymphocytic lymphoma, Flow cytometry, Epidemiology, Relative survival