Leukemia Research
Volume 33, Issue 11 , Pages 1437-1439 , November 2009

Autoimmunity and lymphoma: Is mantle cell lymphoma a mistake of the receptor editing mechanism?

  • Ricardo García-Muñoz

      Affiliations

    • Department of Hematology Cell Therapy Area, Clínica Universitaria University of Navarra, Pamplona (Navarra), Spain
    • Corresponding Author InformationCorresponding author at: Hematology Service, Hospital San Pedro, c/Piqueras 98, 26006 Logroño (La Rioja), Spain. Tel.: +34 941 29 80 00; fax: +34 941 29 87 49.
    • ,
  • Carlos Panizo

      Affiliations

    • Department of Hematology Cell Therapy Area, Clínica Universitaria University of Navarra, Pamplona (Navarra), Spain
    • ,
  • Maurizio Bendandi

      Affiliations

    • Department of Hematology Cell Therapy Area, Clínica Universitaria University of Navarra, Pamplona (Navarra), Spain
    • ,
  • Luis Llorente

      Affiliations

    • Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico

Received 18 March 2009 ,Revised 18 March 2009 ,Accepted 12 May 2009.

References 

  1. Thorselius M, Walsh S, Eriksson I, et al. Somatic hypermutation and V(H) gene usage in mantle cell lymphoma. Eur J Haematol. 2002;68:217–224
  2. Bertoni F, Zucca E, Genini D, Cazzaniga G, Roggero E, Ghielmini M, et al. Immunoglobulin light chain kappa deletion rearrangement as a marker of clonality in mantle cell lymphoma. Leuk Lymphoma. 1999;36:147–150
  3. van der Burg M, Tümkaya T, Boerma M, de Bruin-Versteeg S, Langerak AW, van Dongen JJ. Ordered recombination of immunoglobulin light chain genes occur at the IGK locus but seems less strict at the IGL locus. Blood. 2001;97:1001–1008
  4. Schram BR, Tze LE, Ramsey LB, Liu J, Najera L, Vegoe AL, et al. B cell receptor basal signalling regulates antigen-induced Ig light chain rearrangements. J Immunol. 2008;180:4728–4741
  5. Nemazee D. Receptor editing in lymphocyte development and central tolerance. Nat Rev Immunol. 2006;6:728–740
  6. de Leeuw RJ, Davies JJ, Rosenwald A, Bebb G, Gascoyne RD, Dyer MJ, et al. Comprehensive whole genome array CGH profiling of mantle cell lymphoma model genomes. Hum Mol Genet. 2004;13:1827–1837
  7. Reth M, Gehrmann P, Petrac E, et al. A novel VH to VHDJH joining mechanism in heavy-chain-negative (null) pre-B cells results in heavy-chain production. Nature. 1986;322(6082):840–842
  8. Chen C, Nagy Z, Prak EL, et al. Immunoglobulin heavy chain gene replacement: a mechanism of receptor editing. Immunity. 1995;3:747–755
  9. Hillion S, Saraux A, Youinou P, Jamin C. Expression of RAGs in peripheral B cells outside germinal centers is associated with the expression of CD5. J Immunol. 2005;174:5553–5561
  10. Cappione A, Anolik JH, Pugh-Bernard A, Barnard J, Dutcher P, Silverman G, et al. Germinal center exclusion of autoreactive B cells is defective in human systemic lupus erythematosus. J Clin Invest. 2005;115:3205–3216
  11. Foreman AL, van de Water J, Gougeon ML, Gershwin ME. B cells in autoimmune diseases: insights from analices of immunoglobulin variable (Ig V) gene usage. Autoimmun Rev. 2007;6:387–401
  12. Yurasov S, Wardemann H, Hammersen J, Tsuiji M, Meffre E, Pascual V, et al. Defective B cell tolerance checkpoints in systemic lupus erythematosus. J Exp Med. 2005;201:703–711
  13. Pugh-Bernard A, Silverman G, Cappione AJ, Villano ME, Ryan DH, Insel RA, et al. Regulation of inherently autoreactive VH4-34 B cells in the maintenance of human B cell tolerance. J Clin Invest. 2001;108:1061–1070
  14. Dörner T, Farner NL, Lipsky PE. Ig λ and heavy chain gene usage in early untreated systemic lupus erythematosus suggests intensive B cell stimulation. J Immunol. 1999;163:1027–1036
  15. Lee J, Monson NL, Lipsky PE. The VλJλ repertoire in human fetal spleen: evidence for positive selection and extensive receptor editing. J Immunol. 2000;165:6322–6333
  16. De Wildt RM, Hoet RM, van Venrooij WJ, Tomlinson IM, Winter G. Analysis of heavy and light chain pairings indicates that receptor editing shapes the human repertoire. Mol Biol. 1999;285:895–901
  17. Ekström Smedby K, Vajdic CM, Falster M, Engels EA, Martínez-Maza O, Turner J, et al. Autoimmune disorders and risk of non-Hodgkin lymphoma subtypes: a pooled analysis within the InterLymph Consortium. Blood. 2008;111:4029–4038
  18. García-Muñoz R, Panizo E, Rodríguez-Otero P, Mugueta-Uriaque MC, Rifón J, Llorente L, et al. Systemic lupus erythematosus and Franklin's disease: when somatic mutation mechanism makes a mistake. Rheumatology (Oxford). 2008;47:1105–1106
  19. Wang JH, Alt FW, Gostissa M, Datta A, Murphy M, Alimzhanov MB, et al. Oncogenic transformation in the absence of Xrcc4 targets peripheral B cells that have undergone editing and switching. J Exp Med. 2008;205:3079–3090[Epub 2008 December 8]

PII: S0145-2126(09)00259-8

doi: 10.1016/j.leukres.2009.05.008

Leukemia Research
Volume 33, Issue 11 , Pages 1437-1439 , November 2009

Article Tools

* Image Usage & Resolution