Leukemia Research
Volume 33, Issue 11 , Pages 1437-1439, November 2009

Autoimmunity and lymphoma: Is mantle cell lymphoma a mistake of the receptor editing mechanism?

  • Ricardo García-Muñoz

      Affiliations

    • Department of Hematology Cell Therapy Area, Clínica Universitaria University of Navarra, Pamplona (Navarra), Spain
    • Corresponding Author InformationCorresponding author at: Hematology Service, Hospital San Pedro, c/Piqueras 98, 26006 Logroño (La Rioja), Spain. Tel.: +34 941 29 80 00; fax: +34 941 29 87 49.
    • ,
  • Carlos Panizo

      Affiliations

    • Department of Hematology Cell Therapy Area, Clínica Universitaria University of Navarra, Pamplona (Navarra), Spain
    • ,
  • Maurizio Bendandi

      Affiliations

    • Department of Hematology Cell Therapy Area, Clínica Universitaria University of Navarra, Pamplona (Navarra), Spain
    • ,
  • Luis Llorente

      Affiliations

    • Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico

Received 18 March 2009; received in revised form 18 March 2009; accepted 12 May 2009. published online 07 March 2011.

Abstract 

Mantle cell lymphoma (MCL) is an aggressive B cell malignancy, which is believed to originate from naïve B cells in the mantle zone of lymph nodes.

We speculate that a possible mechanistic hypothesis for the generation of MCL is one in which receptor editing and germinal centre exclusion could be involved in the molecular development and in the display of clinical characteristics of this rare, aggressive and scarcely understood lymphoma.

The hypothesis is supported by a preferential autoimmune related IGVH gene utilization in MCL, where VH3-21, VH4-34 and VH5-51 genes are predominant, and by the fact that MCL expresses immunoglobulin light chain (IgL) lambda more frequently than other non-Hodgkin's lymphomas and that IgL lambda-producing B cells usually delete one or both their IgL kappa genes.

Keywords: Receptor editing, Germinal centre exclusion, Mantle cell lymphoma, Autoimmunity

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PII: S0145-2126(09)00259-8

doi:10.1016/j.leukres.2009.05.008

Leukemia Research
Volume 33, Issue 11 , Pages 1437-1439, November 2009

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