Leukemia Research
Volume 33, Issue 12 , Pages 1696-1698 , December 2009

Differential regulation of 11β-hydroxysteroid dehydrogenase-1 by dexamethasone in glucocorticoid-sensitive and -resistant childhood lymphoblastic leukemia

  • Shuji Sai

      Affiliations

    • Department of Pediatrics, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu 431-3192, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81 53 435 2312; fax: +81 53 435 2311.
    • ,
  • Yuichi Nakagawa

      Affiliations

    • Department of Pediatrics, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu 431-3192, Japan
    • ,
  • Kimiyoshi Sakaguchi

      Affiliations

    • Department of Pediatrics, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu 431-3192, Japan
    • ,
  • Shuichi Okada

      Affiliations

    • Department of Pediatrics, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu 431-3192, Japan
    • ,
  • Hiroyoshi Takahashi

      Affiliations

    • Department of Pediatrics, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu 431-3192, Japan
    • ,
  • Teruaki Hongo

      Affiliations

    • Department of Pediatrics, Iwata City Hospital, Iwata 438-8550, Japan
    • ,
  • Jonathan R. Seckl

      Affiliations

    • Endocrinology Unit, Centre for Cardiovascular Science, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, United Kingdom
    • ,
  • Karen E. Chapman

      Affiliations

    • Endocrinology Unit, Centre for Cardiovascular Science, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, United Kingdom
    • ,
  • Takehiko Ohzeki

      Affiliations

    • Department of Pediatrics, Hamamatsu University School of Medicine, 1-20-1 Handayama, Hamamatsu 431-3192, Japan

Received 16 February 2009 ,Revised 16 February 2009 ,Accepted 14 April 2009.

References 

  1. Seckl JR. 11β-Hydroxysteroid dehydrogenases: changing glucocorticoid action. Curr Opin Pharmacol. 2004;4:597–602
  2. Hongo T, Yajima S, Sakurai M, Horikoshi Y, Hanada R. In vitro drug sensitivity testing can predict induction failure and early relapse of childhood acute lymphoblastic leukemia. Blood. 1997;89:2959–2965
  3. Yang Z, Guo C, Zhu P, Li W, Myatt L, Sun K. Role of glucocorticoid receptor and CCAAT/enhancer-binding protein α in the feed-forward induction of 11β-hydroxysteroid dehydrogenase type 1 expression by cortisol in human amnion fibroblasts. J Endocrinol. 2007;195:241–253
  4. Sai S, Esteves CL, Kelly V, Michailidou Z, Anderson K, Coll AP, et al. Glucocorticoid regulation of the promoter of 11β-hydroxysteroid dehydrogenase type 1 is indirect and requires C/EBPβ. Mol Endocrinol. 2008;22:2049–2060
  5. Cooper CL, Berrier AL, Roman C, Calame KL. Limited expression of C/EBP family proteins during B lymphocyte development. Negative regulator Ig/EBP predominates early and activator NF-IL-6 is induced later. J Immunol. 1994;153:5049–5058
  6. Rask E, Olsson T, Söderberg S, Andrew R, Livingstone DE, Johnson O, et al. Tissue-specific dysregulation of cortisol metabolism in human obesity. J Clin Endocrinol Metab. 2001;86:1418–1421
  7. Masuzaki H, Paterson J, Shinyama H, Morton NM, Mullins JJ, Seckl JR, et al. A transgenic model of visceral obesity and the metabolic syndrome. Science. 2001;294:2166–2170
  8. Ramdas J, Liu W, Harmon JM. Glucocorticoid-induced cell death requires autoinduction of glucocorticoid receptor expression in human leukemic T cells. Cancer Res. 1999;59:1378–1385

☆ Presented in abstract form at the 90th Annual Meeting of the Endocrine Society, 17 June 2008.

PII: S0145-2126(09)00193-3

doi: 10.1016/j.leukres.2009.04.016

Leukemia Research
Volume 33, Issue 12 , Pages 1696-1698 , December 2009

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