Leukemia Research
Volume 33, Issue 11 , Pages 1499-1504 , November 2009

Identification of mitochondrial genome concatemers in AIDS-associated lymphomas and lymphoid cell lines

  • Felipe Bedoya

      Affiliations

    • Department of Molecular Medicine, College of Medicine, University of South Florida, Tampa, FL 33612, United States
    • These authors contributed equally to this work.
  • ,
  • Maria M. Medveczky

      Affiliations

    • Department of Molecular Medicine, College of Medicine, University of South Florida, Tampa, FL 33612, United States
    • These authors contributed equally to this work.
  • ,
  • Troy C. Lund

      Affiliations

    • Department of Pediatrics, University of Minnesota, Minneapolis, MN, United States
  • ,
  • Andras Perl

      Affiliations

    • Department of Medicine, State University of New York, Syracuse, NY, United States
  • ,
  • Joseph Horvath

      Affiliations

    • Hemispherx Biopharma, Inc., New Brunswick, NJ, United States
  • ,
  • Stephen D. Jett

      Affiliations

    • Department of Cell Biology and Physiology, University of New Mexico, Albuquerque, NM, United States
  • ,
  • Peter G. Medveczky

      Affiliations

    • Department of Molecular Medicine, College of Medicine, University of South Florida, Tampa, FL 33612, United States
    • Corresponding Author InformationCorresponding author. Fax: +1 813 396 9188.

Received 13 December 2008 ,Revised 11 March 2009 ,Accepted 12 March 2009.

References 

  1. Biggar RJ, Jaffe ES, Goedert JJ, Chaturvedi A, Pfeiffer R, Engels EA. Hodgkin lymphoma and immunodeficiency in persons with HIV/AIDS. Blood. 2006;108(12):3786–3791
  2. Carbone A, Gloghini A. AIDS-related lymphomas: from pathogenesis to pathology. Br J Haematol. 2005;130(5):662–670
  3. Grogg KL, Miller RF, Dogan A. HIV infection and lymphoma. J Clin Pathol. 2007;60(12):1365–1372
  4. Goedert JJ. The epidemiology of acquired immunodeficiency syndrome malignancies. Semin Oncol. 2000;27(4):390–401
  5. Knowles DM. Etiology and pathogenesis of AIDS-related non-Hodgkin's lymphoma. Hematol Oncol Clin North Am. 2003;17(3):785–820
  6. Loren AW, Porter DL, Stadtmauer EA, Tsai DE. Post-transplant lymphoproliferative disorder: a review. Bone Marrow Transpl. 2003;31(3):145–155
  7. Bellan C, Lazzi S, De Falco G, Nyongo A, Giordano A, Leoncini L. Burkitt's lymphoma: new insights into molecular pathogenesis. J Clin Pathol. 2003;56(3):188–192
  8. Gardella T, Medveczky P, Sairenji T, Mulder C. Detection of circular and linear herpesvirus DNA molecules in mammalian cells by gel electrophoresis. J Virol. 1984;50(1):248–254
  9. Brandon M, Baldi P, Wallace DC. Mitochondrial mutations in cancer. Oncogene. 2006;25(34):4647–4662
  10. Gasparre G, Porcelli AM, Bonora E, Pennisi LF, Toller M, Iommarini L, et al. Disruptive mitochondrial DNA mutations in complex I subunits are markers of oncocytic phenotype in thyroid tumors.. Proc Natl Acad Sci USA. 2007;104(21):9001–9006
  11. Mithani SK, Taube JM, Zhou S, Smith IM, Koch WM, Westra WH, et al. Mitochondrial mutations are a late event in the progression of head and neck squamous cell cancer. Clin Cancer Res. 2007;13(15):4331–4335
  12. Petros JA, Baumann AK, Ruiz-Pesini E, Amin MB, Sun CQ, Hall J, et al. mtDNA mutations increase tumorigenicity in prostate cancer. Proc Natl Acad Sci USA. 2005;102(3):719–724
  13. Wallace DC. Mitochondria and cancer: Warburg addressed. Cold Spring Harb Symp Quant Biol. 2005;70:363–374
  14. Medveczky P, Chang C-W, Oste C, Mulder C. Rapid vacuum driven transfer of DNA and RNA from gels to solid supports. Biotechniques. 1987;5(3):242
  15. Rieder MJ, Taylor SL, Tobe VO, Nickerson DA. Automating the identification of DNA variations using quality-based fluorescence re-sequencing: analysis of the human mitochondrial genome. Nucleic Acids Res. 1998;26(4):967–973
  16. Zahn RK, Tiesler E, Kleinschmidt AK, Lang D. A preservation and preparation process for desoxyribonucleic acids and their raw materials. Biochem Z. 1962;336:281–298
  17. Lang D, Mitani M. Simplified quantitative electron microscopy of biopolymers. Biopolymers. 1970;9(3):373–379
  18. Sanchez-Cespedes M, Parrella P, Nomoto S, Cohen D, Xiao Y, Esteller M, et al. Identification of a mononucleotide repeat as a major target for mitochondrial DNA alterations in human tumors. Cancer Res. 2001;61(19):7015–7019
  19. Bonnefoy N, Fox TD. Directed alteration of Saccharomyces cerevisiae mitochondrial DNA by biolistic transformation and homologous recombination. Methods Mol Biol. 2007;372:153–166
  20. Khazi FR, Edmondson AC, Nielsen BL. An Arabidopsis homologue of bacterial RecA that complements an E. coli recA deletion is targeted to plant mitochondria. Mol Genet Genom. 2003;269(4):454–463
  21. Kraytsberg Y, Schwartz M, Brown TA, Ebralidse K, Kunz WS, Clayton DA, et al. Recombination of human mitochondrial DNA. Science. 2004;304(5673):981
  22. Thyagarajan B, McCormick-Graham M, Romero DP, Campbell C: . Characterization of homologous DNA recombination activity in normal and immortal mammalian cells. Nucleic Acids Res. 1996;24(20):4084–4091
  23. Clayton DA: . Mitochondrial DNA replication: what we know. IUBMB Life. 2003;55(4–5):213–217
  24. Komarov AP, Rokhlin OW, Yu CA, Gudkov AV: . Functional genetic screening reveals the role of mitochondrial cytochrome b as a mediator of FAS-induced apoptosis. Proc Natl Acad Sci USA. 2008;105(38):14453–14458
  25. Krammer PH: . CD95's deadly mission in the immune system. Nature. 2000;407(6805):789–795
  26. Thome M, Schneider P, Hofmann K, Fickenscher H, Meinl E, Neipel F, et al. Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors. Nature. 1997;386(6624):517–521
  27. Bertin J, Armstrong RC, Ottilie S, Martin DA, Wang Y, Banks S, et al. Death effector domain-containing herpesvirus and poxvirus proteins inhibit both Fas- and TNFR1-induced apoptosis. Proc Natl Acad Sci USA. 1997;94(4):1172–1176
  28. Clerkin JS, Naughton R, Quiney C, Cotter TG. Mechanisms of ROS modulated cell survival during carcinogenesis. Cancer Lett. 2008;266(1):30–36
  29. Galaris D, Skiada V, Barbouti A. Redox signaling and cancer: the role of “labile” iron. Cancer Lett. 2008;266(1):21–29
  30. Pinti M, Salomoni P, Cossarizza A. Anti-HIV drugs and the mitochondria. Biochim Biophys Acta. 2006;1757(5–6):700–707
  31. Martin JL, Brown CE, Matthews-Davis N, Reardon JE. Effects of antiviral nucleoside analogs on human DNA polymerases and mitochondrial DNA synthesis. Antimicrob Agents Chemother. 1994;38(12):2743–2749
  32. Yamanaka H, Gatanaga H, Kosalaraksa P, Matsuoka-Aizawa S, Takahashi T, Kimura S, et al. Novel mutation of human DNA polymerase gamma associated with mitochondrial toxicity induced by anti-HIV treatment. J Infect Dis. 2007;195(10):1419–1425
  33. Medveczky MM, Szomolanyi E, Hesselton R, DeGrand D, Geck P, Medveczky PG. Herpesvirus saimiri strains from three DNA subgroups have different oncogenic potentials in New Zealand white rabbits. J Virol. 1989;63(9):3601–3611

PII: S0145-2126(09)00135-0

doi: 10.1016/j.leukres.2009.03.012

Leukemia Research
Volume 33, Issue 11 , Pages 1499-1504 , November 2009