« Previous
Next »
Leukemia Research
Volume 33, Issue 11
, Pages 1570-1573
, November 2009
Comparative analysis of IL6 promoter and receptor polymorphisms in myelodysplasia and multiple myeloma
References
- Systemic levels of interleukin-6 and matrix metalloproteinase-9 in patients with multiple myeloma may be useful as prognostic indexes of bone disease. Clin Chem Lab Med. 2005;43:934–938
- Serum proinflammatory mediators at different periods of therapy in patients with multiple myeloma. Mediators Inflamm. 2005;2005:171–174
- The clinical and prognostic significance of erythrocyte sedimentation rate (ESR), serum interleukin-6 (IL-6) and acute phase protein levels in multiple myeloma. Clin Lab Haematol. 2003;25:41–46
- Circulating interleukin-6 (IL-6) in patients with myelodysplastic syndromes. Leukemia Res. 1999;23:S23–S28[Abstr 78]
- . Cognitive impairment, fatigue, and cytokine levels in patients with acute myelogenous leukemia or myelodysplastic syndrome. Cancer. 2005;104:788–793
- . Age-associated increased interleukin-6 gene expression, late-life diseases, and frailty. Annu Rev Med. 2000;51:245–270
- Interleukin-6-related genotypes, body mass index, and risk of multiple myeloma and plasmacytoma. Cancer Epidemiol Biomarkers Prev. 2006;15:2285–2291
- Interleukin 6, tumour necrosis factor alpha and lymphotoxin alpha polymorphisms in monoclonal gammopathy of uncertain significance and multiple myeloma. Br J Haematol. 2001;112:249–251
- IL-6 and IL-10 promoter gene polymorphisms do not associate with the susceptibility for multiple myeloma. Immunol Lett. 2005;96:241–246
- Interleukin 6, tumour necrosis factor alpha, interleukin 1beta and interleukin 1 receptor antagonist promoter or coding gene polymorphisms in multiple myeloma. Br J Haematol. 2000;109:39–45
- . A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res. 1988;16:1215
- . Analysis of polymorphism at site −174 G/C of interleukin-6 promoter region in multiple myeloma. Braz J Med Biol Res. 2007;40:265–267
- . Interleukin-6 biology is coordinated by membrane-bound and soluble receptors: role in inflammation and cancer. J Leukoc Biol. 2006;80:227–236
- . Polymorphisms in the IL-6 receptor (IL-6R) gene: strong evidence that serum levels of soluble IL-6R are genetically influenced. Genes Immun. 2004;5:513–516
- A common variant of the interleukin 6 receptor (IL-6r) gene increases IL-6r and IL-6 levels, without other inflammatory effects. Genes Immun. 2007;8:552–559
- The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis. J Clin Invest. 1998;102:1369–1376
- The −174C/G locus affects in vitro/in vivo IL-6 production during aging. Exp Gerontol. 2002;37:309–314
- . The impact of interleukin-6 promoter −597/−572/−174genotype on interleukin-6 production after lipopolysaccharide stimulation. Clin Exp Immunol. 2007;147:339–345
- . Hepcidin a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood. 2003;101:2461–2463
- . The significance of the hemochromatosis genetic variants in multiple myeloma in comparison to that of myelodysplastic syndrome. Ann Hematol. 2006;85:869–871
- . Mechanisms of disease: the role of hepcidin in iron homeostasis—implications for hemochromatosis and other disorders. Nat Clin Pract Gastroenterol Hepatol. 2004;1:39–45
- STAT3 is required for IL-6-gp130-dependent activation of hepcidin in vivo. Gastroenterology. 2007;132:294–300
- High incidence of hemochromatosis gene mutations in the myelodysplastic syndrome: the Budapest Study on 50 patients. Acta Haematol. 2003;109:64–67
- Hemochromatosis-associated gene mutations in patients with myelodysplastic syndromes with refractory anemia with ringed sideroblasts. Am J Hematol. 2007;82:1076–1079
PII: S0145-2126(09)00117-9
doi: 10.1016/j.leukres.2009.03.009
© 2009 Elsevier Ltd. All rights reserved.
« Previous
Next »
Leukemia Research
Volume 33, Issue 11
, Pages 1570-1573
, November 2009
