Leukemia Research
Volume 33, Issue 12 , Pages 1604-1608, December 2009

Long-term survival in chronic myelocytic leukemia after a first primary malignancy

  • Hermann Brenner

      Affiliations

    • Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Str. 20, D-69115 Heidelberg, Germany
    • Corresponding Author InformationCorresponding author. Tel.: +49 6221 548140; fax: +49 6221 548142.
    • ,
  • Adam Gondos

      Affiliations

    • Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Str. 20, D-69115 Heidelberg, Germany
    • ,
  • Dianne Pulte

      Affiliations

    • Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Bergheimer Str. 20, D-69115 Heidelberg, Germany
    • Weill Cornell Medical Center, New York, USA

Received 26 December 2008; received in revised form 27 January 2009; accepted 28 January 2009. published online 07 March 2011.

Abstract 

Within the past 10–15 years, major advances in therapy have strongly improved prognosis of patients with chronic myelocytic leukaemia (CML). We estimated trends in 5- and 10-year relative survival of patients developing CML after a previous malignancy in the United States from 1990–1994 to 2000–2004. Period analysis was employed to disclose recent developments with minimum delay. Overall, 5- and 10-year relative survival increased from 17.6% to 37.7% (p<0.0001) and from 7.6% to 23.8% (p<0.0001), respectively. Improvements were particularly strong in younger age groups. Prognosis of CML patients with previous malignancy no longer lags behind prognosis of patients with primary CML.

Keywords: Cancer registries, Chronic myelocytic leukemia, Neoplasm, Survival

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PII: S0145-2126(09)00057-5

doi:10.1016/j.leukres.2009.01.042

Leukemia Research
Volume 33, Issue 12 , Pages 1604-1608, December 2009

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