Leukemia Research
Volume 33, Issue 6 , Pages 817-822 , June 2009

Epigenetic control of differential expression of specific ERG isoforms in acute T-lymphoblastic leukemia

Received 26 June 2008 ,Revised 12 November 2008 ,Accepted 13 November 2008.

References 

  1. Seth A, Watson DK. ETS transcription factors and their emerging roles in human cancer. Eur J Cancer. 2005;41:2462–2478
  2. Oikawa T. ETS transcription factors: possible targets for cancer therapy. Cancer Sci. 2004;95:626–633
  3. Scott GK, Chang CH, Erny KM, Xu F, Fredericks WJ, Rauscher FJ, et al. Ets regulation of the erbB2 promoter. Oncogene. 2000;19:6490–6502
  4. Duda DG, Sunamura M, Lefter LP, Furukawa T, Yokoyama T, Yatsuoka T, et al. Restoration of SMAD4 by gene therapy reverses the invasive phenotype in pancreatic adenocarcinoma cells. Oncogene. 2003;22:6857–6864
  5. Sorensen PH, Lessnick SL, Lopez-Terrada D, Liu XF, Triche TJ, Denny CT. A second Ewing's sarcoma translocation, t(21;22), fuses the EWS gene to another ETS-family transcription factor, ERG. Nat Genet. 1994;6:146–151
  6. Kong XT, Ida K, Ichikawa H, Shimizu K, Ohki M, Maseki N, et al. Consistent detection of TLS/FUS-ERG chimeric transcripts in acute myeloid leukemia with t(16; 21)(p11; q22) and identification of a novel transcript. Blood. 1997;90:1192–1199
  7. Tomlins SA, Rhodes DR, Perner S, Dhanasekaran SM, Mehra R, Sun XW, et al. Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer. Science. 2005;310:644–648
  8. Baldus CD, Liyanarachchi S, Mrozek K, Auer H, Tanner SM, Guimond M, et al. Acute myeloid leukemia with complex karyotypes and abnormal chromosome 21: amplification discloses overexpression of APP, ETS2, and ERG genes. Proc Natl Acad Sci USA. 2004;101:3915–3920
  9. Hart AH, Corrick CM, Tymms MJ, Hertzog PJ, Kola I. Human ERG is a proto-oncogene with mitogenic and transforming activity. Oncogene. 1995;10:1423–1430
  10. McLaughlin F, Ludbrook VJ, Cox J, von CI, Brown S, Randi AM. Combined genomic and antisense analysis reveals that the transcription factor Erg is implicated in endothelial cell differentiation. Blood. 2001;98:3332–3339
  11. Iwamoto M, Tamamura Y, Koyama E, Komori T, Takeshita N, Williams JA, et al. Transcription factor ERG and joint and articular cartilage formation during mouse limb and spine skeletogenesis. Dev Biol. 2007;305:40–51
  12. Rainis L, Toki T, Pimanda JE, Rosenthal E, Machol K, Strehl S, et al. The proto-oncogene ERG in megakaryoblastic leukemias. Cancer Res. 2005;65:7596–7602
  13. Lefebvre JM, Haks MC, Carleton MO, Rhodes M, Sinnathamby G, Simon MC, et al. Enforced expression of Spi-B reverses T lineage commitment and blocks {beta}-selection. J Immunol. 2005;174:6184–6194
  14. Anderson MK, Hernandez-Hoyos G, Diamond RA, Rothenberg EV. Precise developmental regulation of Ets family transcription factors during specification and commitment to the T cell lineage. Development. 1999;126:3131–3148
  15. Baldus CD, Burmeister T, Martus P, Schwartz S, Gokbuget N, Bloomfield CD, et al. High expression of the ETS transcription factor ERG predicts adverse outcome in acute T-lymphoblastic leukemia in adults. J Clin Oncol. 2006;24:4714–4720
  16. Marcucci G, Baldus CD, Ruppert AS, Radmacher MD, Mrozek K, Whitman SP, et al. Overexpression of the ETS-related gene, ERG, predicts a worse outcome in acute myeloid leukemia with normal karyotype: a cancer and leukemia group B study. J Clin Oncol. 2005;23:9234–9242
  17. Owczarek CM, Portbury KJ, Hardy MP, O’Leary DA, Kudoh J, Shibuya K, et al. Detailed mapping of the ERG-ETS2 interval of human chromosome 21 and comparison with the region of conserved synteny on mouse chromosome 16. Gene. 2004;324:65–77
  18. Hewett PW, Nishi K, Daft EL, Clifford MJ. Selective expression of erg isoforms in human endothelial cells. Int J Biochem Cell Biol. 2001;33:347–355
  19. Murakami KF, Mavrothalassitis GF, Bhat NKFAU, Fisher RJFAU, Papas TS. Human ERG-2 protein is a phosphorylated DNA-binding protein—a distinct member of the ets family. Oncogene. 1993;1559–1566
  20. Petrovics G, Liu A, Shaheduzzaman S, Furasato B, Sun C, Chen Y, et al. Frequent overexpression of ETS-related gene-1 (ERG1) in prostate cancer transcriptome. Oncogene. 2005;24:3847–3852
  21. Duterque-Coquillaud M, Niel C, Plaza S, Stehelin D. New human erg isoforms generated by alternative splicing are transcriptional activators. Oncogene. 1993;8:1865–1873
  22. Rao VN, Papas TS, Reddy ES. erg, a human ets-related gene on chromosome 21: alternative splicing, polyadenylation, and translation. Science. 1987;237:635–639
  23. Prasad DD, Rao VN, Lee L, Reddy ES. Differentially spliced erg-3 product functions as a transcriptional activator. Oncogene. 1994;9:669–673
  24. Loose M, Patient R. Global genetic regulatory networks controlling hematopoietic cell fates. Curr Opin Hematol. 2006;13:229–236
  25. Carrere S, Verger A, Flourens A, Stehelin D, Duterque-Coquillaud M. Erg proteins, transcription factors of the Ets family, form homo, heterodimers and ternary complexes via two distinct domains. Oncogene. 1998;16:3261–3268
  26. Esteller M. Profiling aberrant DNA methylation in hematologic neoplasms: a view from the tip of the iceberg. Clin Immunol. 2003;109:80–88
  27. Melki JR, Clark SJ. DNA methylation changes in leukaemia. Semin Cancer Biol. 2002;12:347–357

PII: S0145-2126(08)00502-X

doi: 10.1016/j.leukres.2008.11.012

Leukemia Research
Volume 33, Issue 6 , Pages 817-822 , June 2009