Leukemia Research
Volume 33, Issue 6 , Pages 823-828 , June 2009

Rutin inhibits the proliferation of murine leukemia WEHI-3 cells in vivo and promotes immune response in vivo

  • Jing-Pin Lin

      Affiliations

    • School of Chinese Medicine, China Medical University, Taichung 404, Taiwan
  • ,
  • Jai-Sing Yang

      Affiliations

    • Department of Pharmacology, China Medical University, Taichung 404, Taiwan
  • ,
  • Chi-Cheng Lu

      Affiliations

    • Department of Life Sciences, National Chung Hsing University, Taichung 402, Taiwan
  • ,
  • Jo-Hua Chiang

      Affiliations

    • Department of Life Sciences, National Chung Hsing University, Taichung 402, Taiwan
  • ,
  • Chang-Lin Wu

      Affiliations

    • Department of Biological Science and Technology, China Medical University, Taichung 404, Taiwan
  • ,
  • Jen-Jyh Lin

      Affiliations

    • Division of Cardiology, Department of Medicine, China Medical University Hospital, Taichung 404, Taiwan
  • ,
  • Hui-Lu Lin

      Affiliations

    • Department of Ophthalmology, China Medical University Hospital, Taichung 404, Taiwan
  • ,
  • Mei-Due Yang

      Affiliations

    • Department of Surgery China Medical University Hospital, Taichung 404, Taiwan
  • ,
  • Kuo-Ching Liu

      Affiliations

    • Department of Medical Laboratory Science and Biotechnology, China Medical University, Taichung 404, Taiwan
  • ,
  • Tsan-Hung Chiu

      Affiliations

    • Department of OBS/GYN, China Medical University Hospital, Taichung 404, Taiwan
  • ,
  • Jing-Gung Chung

      Affiliations

    • Department of Biological Science and Technology, China Medical University, Taichung 404, Taiwan
    • Department of Biotechnology, Asia University, Wufeng, Taichung County 413, Taiwan
    • Corresponding Author InformationCorresponding author at: Department of Biological Science and Technology, China Medical University, No. 91, Hsueh-Shih Road, Taichung 404, Taiwan. Tel.: +886 4 2205 3366x2501; fax: +886 4 2205 3764.

Received 9 August 2008 ,Revised 20 September 2008 ,Accepted 24 September 2008.

References 

  1. Jensen CD, Block G, Buffler P, et al. Maternal dietary risk factors in childhood acute lymphoblastic leukemia (United States). Cancer Causes Control. 2004;15:559–570
  2. Mahmoud NN, Carothers AM, Grunberger D, et al. Plant phenolics decrease intestinal tumors in an animal model of familial adenomatous polyposis. Carcinogenesis. 2000;21:921–927
  3. Mutoh M, Takahashi M, Fukuda K, et al. Suppression by flavonoids of cyclooxygenase-2 promoter-dependent transcriptional activity in colon cancer cells: structure-activity relationship. Jpn J Cancer Res. 2000;91:686–691
  4. Wenzel U, Kuntz S, Brendel MD, et al. Dietary flavone is a potent apoptosis inducer in human colon carcinoma cells. Cancer Res. 2000;60:3823–3831
  5. Kelloff GJ, Crowell JA, Steele VE, et al. Progress in cancer chemoprevention: development of diet-derived chemopreventive agents. J Nutr. 2000;130:467S–471S
  6. Deschner EE, Ruperto JF, Wong GY, et al. The effect of dietary quercetin and rutin on AOM-induced acute colonic epithelial abnormalities in mice fed a high-fat diet. Nutr Cancer. 1993;20:199–204
  7. Matsukawa Y, Nishino H, Okuyama Y, et al. Effects of quercetin and/or restraint stress on formation of aberrant crypt foci induced by azoxymethane in rat colons. Oncology. 1997;54:118–121
  8. Tanaka T, Kawabata K, Honjo S, et al. Inhibition of azoxymethane-induced aberrant crypt foci in rats by natural compounds, caffeine, quercetin and morin. Oncol Rep. 1999;6:1333–1340
  9. Verma AK, Johnson JA, Gould MN, et al. Inhibition of 7,12-dimethylbenz(a)anthracene- and N-nitrosomethylurea-induced rat mammary cancer by dietary flavonol quercetin. Cancer Res. 1988;48:5754–5758
  10. Su CC, Yang JS, Lin SY, et al. Curcumin inhibits WEHI-3 leukemia cells in BALB/c mice in vivo. In Vivo. 2008;22:63–68
  11. Stachowska E, Baskiewicz-Masiuk M, Dziedziejko V, et al. Conjugated linoleic acids can change phagocytosis of human monocytes/macrophages by reduction in Cox-2 expression. Lipids. 2007;42:707–716
  12. Deschner EE, Ruperto J, Wong G, et al. Quercetin and rutin as inhibitors of azoxymethanol-induced colonic neoplasia. Carcinogenesis. 1991;12:1193–1196
  13. Taghian AG, Suit HD. Animal systems for translational research in radiation oncology. Acta Oncol. 1999;38:829–838
  14. Zips D, Thames HD, Baumann M. New anticancer agents: in vitro and in vivo evaluation. In Vivo. 2005;19:1–7
  15. He Q, Na X. The effects and mechanisms of a novel 2-aminosteroid on murine WEHI-3B leukemia cells in vitro and in vivo. Leuk Res. 2001;25:455–461
  16. Warner NL, Moore MA, Metcalf D. A transplantable myelomonocytic leukemia in BALB-c mice: cytology, karyotype, and muramidase content. J Natl Cancer Inst. 1969;43:963–982
  17. Abe J, Morikawa M, Miyamoto K, et al. Synthetic analogues of vitamin D3 with an oxygen atom in the side chain skeleton. A trial of the development of vitamin D compounds which exhibit potent differentiation-inducing activity without inducing hypercalcemia. FEBS Lett. 1987;226:58–62
  18. Satchell DP, Norman AW. Metabolism of the cell differentiating agent 1alpha,25(OH)2-16-ene-23-yne vitamin D3 by leukemic cells. J Steroid Biochem Mol Biol. 1996;57:117–124
  19. Wietrzyk J, Chodynski M, Fitak H, et al. Antitumor properties of diastereomeric and geometric analogs of vitamin D3. Anticancer Drugs. 2007;18:447–457

PII: S0145-2126(08)00431-1

doi: 10.1016/j.leukres.2008.09.032

Leukemia Research
Volume 33, Issue 6 , Pages 823-828 , June 2009