Leukemia Research
Volume 33, Issue 5 , Pages 731-734 , May 2009

High levels of BACH2 associated with lower levels of BCL2 transcript abundance in t(14;18)(q21;q34) translocation positive non-Hodgkin’s lymphoma

  • Michael Green

      Affiliations

    • Genomics Research Centre, Griffith Institute for Health and Medical Research, Griffith University, Queensland 9726, Australia
    • Griffith Medical Research College, A Joint Program of Griffith University and the Queensland Institute of Medical Research, QIMR, Queensland 4029, Australia
    • ,
  • Maher K. Gandhi

      Affiliations

    • Griffith Medical Research College, A Joint Program of Griffith University and the Queensland Institute of Medical Research, QIMR, Queensland 4029, Australia
    • Clinical Immunohaematology Laboratory, The Queensland Institute of Medical Research, Queensland, Australia
    • The Princess Alexandra Hospital, Queensland Health, Queensland 4102, Australia
    • ,
  • Emily Camilleri

      Affiliations

    • Genomics Research Centre, Griffith Institute for Health and Medical Research, Griffith University, Queensland 9726, Australia
    • ,
  • Paula Marlton

      Affiliations

    • The Princess Alexandra Hospital, Queensland Health, Queensland 4102, Australia
    • ,
  • Rod Lea

      Affiliations

    • Genomics Research Centre, Griffith Institute for Health and Medical Research, Griffith University, Queensland 9726, Australia
    • Institute of Environmental Science and Research, Wellington, New Zealand
    • ,
  • Lyn Griffiths

      Affiliations

    • Genomics Research Centre, Griffith Institute for Health and Medical Research, Griffith University, Queensland 9726, Australia
    • Griffith Medical Research College, A Joint Program of Griffith University and the Queensland Institute of Medical Research, QIMR, Queensland 4029, Australia
    • Corresponding Author InformationCorresponding author at: Genomics Research Centre, Griffith Institute for Health and Medical Research, Griffith University, PMB 50 Gold Coast Mail Centre, Queensland 9726, Australia. Tel.: +61 7 5552 8808; fax: +61 7 5552 9081.

Received 28 May 2008 ,Revised 5 September 2008 ,Accepted 5 September 2008.

References 

  1. Kramer M, Hermans J, Wijburg E, Philippo K, Geelen E, van Krieken J, et al. Clinical relevance of BCL2, BCL6, and MYC rearrangements in diffuse large B-cell lymphoma. Blood. 1998;92:3152–3162
  2. Muto A, Hoshino H, Madisen L, Yanai N, Obinata M, Karasuyama H, et al. Identification of Bach2 as a B-cell-specific partner for small Maf proteins that negatively regulate the immunoglobulin heavy chain gene 3′ enhancer. EMBO J. 1998;17:5734–5743
  3. Heckman C, Cao T, Somsouk L, Duan H, Mehew J, Zhang C, et al. Critical elements of the immunoglobulin heavy chain enhancers for deregulated expression of Bcl-2. Cancer Res. 2003;63:6666–6673
  4. Alizadeh A, Eisen M, Davis R, Ma C, Lossoss I, Rosenwald A, et al. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature. 2000;403:503–511
  5. Sakane-Ishikawa E, Nakatsuka S, Tomita Y, Fujita S, Nakamichi I, Takakuwa T, et al. Prognostic significance of BACH2 expression in diffuse large B-cell lymphoma: a study of the Osaka lymphoma study group. J Clin Oncol. 2005;23:8012–8017
  6. Poteat H, Sklar J. A simplified polymerase chain reaction assay for detection of chromosomal translocations in hematologic malignancies. Diagn Mol Pathol. 1997;6:3–9
  7. Livak K, Schmittgen T. Analysis of relative gene expression data using real-time quantitative PCR and the 2−ΔΔCt method. Methods. 2001;25:402–408
  8. Takakuwa T, Luo W, Ham M, Sakane-Ishikawa F, Wada N, Aozasa K. Integration of Epstein-Barr virus into chromosome 6q15 of Burkitt lymphoma cell line (Raji) induces loss of BACH2 expression. Am J Pathol. 2004;164:967–974
  9. Kamio T, Toki T, Kanezaki R, Sasaki S, Tandai S, Terui K, et al. B-cell-specific transcription factor BACH2 modifies the cytotoxic effects of anticancer drugs. Blood. 2003;102:3317–3322

PII: S0145-2126(08)00413-X

doi: 10.1016/j.leukres.2008.09.007

Leukemia Research
Volume 33, Issue 5 , Pages 731-734 , May 2009

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