High levels of BACH2 associated with lower levels of BCL2 transcript abundance in t(14;18)(q21;q34) translocation positive non-Hodgkin’s lymphoma

Green, Michael; Gandhi, Maher K.; Camilleri, Emily; Marlton, Paula; Lea, Rod; Griffiths, Lyn

doi:10.1016/j.leukres.2008.09.007

« Previous Next »Leukemia Research
Volume 33, Issue 5 , Pages 731-734, May 2009

High levels of BACH2 associated with lower levels of BCL2 transcript abundance in t(14;18)(q21;q34) translocation positive non-Hodgkin’s lymphoma

Michael Green
- Genomics Research Centre, Griffith Institute for Health and Medical Research, Griffith University, Queensland 9726, Australia
- Griffith Medical Research College, A Joint Program of Griffith University and the Queensland Institute of Medical Research, QIMR, Queensland 4029, Australia
Maher K. Gandhi
- Griffith Medical Research College, A Joint Program of Griffith University and the Queensland Institute of Medical Research, QIMR, Queensland 4029, Australia
- Clinical Immunohaematology Laboratory, The Queensland Institute of Medical Research, Queensland, Australia
- The Princess Alexandra Hospital, Queensland Health, Queensland 4102, Australia
Emily Camilleri
- Genomics Research Centre, Griffith Institute for Health and Medical Research, Griffith University, Queensland 9726, Australia
Paula Marlton
- The Princess Alexandra Hospital, Queensland Health, Queensland 4102, Australia
Rod Lea
- Genomics Research Centre, Griffith Institute for Health and Medical Research, Griffith University, Queensland 9726, Australia
- Institute of Environmental Science and Research, Wellington, New Zealand
Lyn Griffiths
- Genomics Research Centre, Griffith Institute for Health and Medical Research, Griffith University, Queensland 9726, Australia
- Griffith Medical Research College, A Joint Program of Griffith University and the Queensland Institute of Medical Research, QIMR, Queensland 4029, Australia
- Corresponding author at: Genomics Research Centre, Griffith Institute for Health and Medical Research, Griffith University, PMB 50 Gold Coast Mail Centre, Queensland 9726, Australia. Tel.: +61 7 5552 8808; fax: +61 7 5552 9081.

Received 28 May 2008; received in revised form 5 September 2008; accepted 5 September 2008. published online 07 March 2011.

Abstract

The t(14;18)(q21;q34) BCL2 translocation is a common genetic alteration in follicular and diffuse large B-cell lymphoma. However, it is not invariably associated with BCL2 gene overexpression due to undefined mechanisms that regulate expression from the proximal immunoglobulin heavy-chain (IgH) promoter. The BACH2 transcriptional repressor is able to modulate activity of this promoter. Here we have shown that, in tumor samples with BCL2 translocation, those with high levels of BACH2 had significantly lower BCL2 transcript abundance compared to those with low levels of BACH2. This indicates that BACH2 may be partially responsible for regulation of BCL2 expression from the t(14;18)(q21;q34) translocation.

Keywords: Non-Hodgkin’s lymphoma, Follicular lymphoma, Diffuse large B-cell lymphoma, BACH2, BCL2, t(14 ;18)(q21 ;q34)