Leukemia Research
Volume 33, Issue 2 , Pages 218-221 , February 2009

Sodium butyrate enhances the cytotoxic effect of antineoplastic drugs in human lymphoblastic T-cells

  • M.P. dos Santos

      Affiliations

    • Cancer Research Laboratory, Academic Hospital Research Center, Federal University of Rio Grande do Sul, 90035-903 Porto Alegre, RS, Brazil
    • Medical Sciences Program, Federal University of Rio Grande do Sul, 90035-903 Porto Alegre, RS, Brazil
    • ,
  • G. Schwartsmann

      Affiliations

    • Cancer Research Laboratory, Academic Hospital Research Center, Federal University of Rio Grande do Sul, 90035-903 Porto Alegre, RS, Brazil
    • Department of Internal Medicine, Faculty of Medicine, Federal University of Rio Grande do Sul, 90035-903 Porto Alegre, RS, Brazil
    • ,
  • R. Roesler

      Affiliations

    • Cancer Research Laboratory, Academic Hospital Research Center, Federal University of Rio Grande do Sul, 90035-903 Porto Alegre, RS, Brazil
    • Department of Pharmacology, Institute for Basic Health Sciences, Federal University of Rio Grande do Sul, 90046-900 Porto Alegre, RS, Brazil
    • ,
  • A.L. Brunetto

      Affiliations

    • Cancer Research Laboratory, Academic Hospital Research Center, Federal University of Rio Grande do Sul, 90035-903 Porto Alegre, RS, Brazil
    • Children's Cancer Institute and Pediatric Oncology Unit, Academic Hospital, Federal University of Rio Grande do Sul, 90035-903 Porto Alegre, RS, Brazil
    • ,
  • A.L. Abujamra

      Affiliations

    • Cancer Research Laboratory, Academic Hospital Research Center, Federal University of Rio Grande do Sul, 90035-903 Porto Alegre, RS, Brazil
    • Childreńs Cancer Institute, 90420-140 Porto Alegre, RS, Brazil
    • Corresponding Author InformationCorresponding author at: Cancer Research Laboratory, Children's Cancer Institute, R. Ramiro Barcelos 2350, 3° Leste, 90035-903 Porto Alegre, RS, Brazil. Tel.: +55 51 2102 7616; fax: +55 51 3388-2877.

Received 8 May 2008 ,Revised 8 May 2008 ,Accepted 3 July 2008.

References 

  1. Pui CH, Robison LL, Look AT. Acute lymphoblastic leukaemia. Lancet. 2008;371:1030–1043
  2. Kouraklis G, Theocharis S. Histone deacetylase inhibitors: a novel target of anticancer therapy (review). Oncol Rep. 2006;15:489–494
  3. Conway RM, Madigan MC, Billson FA, Penfold PL. Vincristine- and cisplatin-induced apoptosis in human retinoblastoma. Potentiation by sodium butyrate. Eur J Cancer. 1998;34:1741–1748
  4. Louis M, Rosato RR, Brault L, Osbild S, Battaglia E, Yang XH, et al. The histone deacetylase inhibitor sodium butyrate induces breast cancer cell apoptosis through diverse cytotoxic actions including glutathione depletion and oxidative stress. Int J Oncol. 2004;25:1701–1711
  5. Sonnemann J, Kumar KS, Heesch S, Müller C, Hartwig C, Maass M, et al. Histone deacetylase inhibitors induce cell death and enhance the susceptibility to ionizing radiation, etoposide, and TRAIL in medulloblastoma cells. Int J Oncol. 2006;28:755–766
  6. Kurz EU, Wilson SE, Leader KB, Sampey BP, Allan WP, Yalowich JC, et al. The histone deacetylase inhibitor sodium butyrate induces DNA topoisomerase II alpha expression and confers hypersensitivity to etoposide in human leukemic cell lines. Mol Cancer Ther. 2001;1:121–131
  7. Ramos MG, Rabelo FL, Brumatti G, Bueno-da-Silva AE, Amarante-Mendes GP, Alvarez-Leite JI. Butyrate increases apoptosis induced by different antineoplastic drugs in monocytic leukemia cells. Chemotherapy. 2004;50:221–228
  8. Siitonen T, Koistinen P, Savolainen ER. Increase in Ara-C cytotoxicity in the presence of valproate, a histone deacetylase inhibitor, is associated with the concurrent expression of cyclin D1 and p27(Kip 1) in acute myeloblastic leukemia cells. Leuk Res. 2005;29:1335–1342

PII: S0145-2126(08)00329-9

doi: 10.1016/j.leukres.2008.07.003

Leukemia Research
Volume 33, Issue 2 , Pages 218-221 , February 2009

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