Sodium butyrate enhances the cytotoxic effect of antineoplastic drugs in human lymphoblastic T-cells

dos Santos, M.P.; Schwartsmann, G.; Roesler, R.; Brunetto, A.L.; Abujamra, A.L.

doi:10.1016/j.leukres.2008.07.003

« Previous Next »Leukemia Research
Volume 33, Issue 2 , Pages 218-221, February 2009

Sodium butyrate enhances the cytotoxic effect of antineoplastic drugs in human lymphoblastic T-cells

M.P. dos Santos
- Cancer Research Laboratory, Academic Hospital Research Center, Federal University of Rio Grande do Sul, 90035-903 Porto Alegre, RS, Brazil
- Medical Sciences Program, Federal University of Rio Grande do Sul, 90035-903 Porto Alegre, RS, Brazil
G. Schwartsmann
- Cancer Research Laboratory, Academic Hospital Research Center, Federal University of Rio Grande do Sul, 90035-903 Porto Alegre, RS, Brazil
- Department of Internal Medicine, Faculty of Medicine, Federal University of Rio Grande do Sul, 90035-903 Porto Alegre, RS, Brazil
R. Roesler
- Cancer Research Laboratory, Academic Hospital Research Center, Federal University of Rio Grande do Sul, 90035-903 Porto Alegre, RS, Brazil
- Department of Pharmacology, Institute for Basic Health Sciences, Federal University of Rio Grande do Sul, 90046-900 Porto Alegre, RS, Brazil
A.L. Brunetto
- Cancer Research Laboratory, Academic Hospital Research Center, Federal University of Rio Grande do Sul, 90035-903 Porto Alegre, RS, Brazil
- Children's Cancer Institute and Pediatric Oncology Unit, Academic Hospital, Federal University of Rio Grande do Sul, 90035-903 Porto Alegre, RS, Brazil
A.L. Abujamra
- Cancer Research Laboratory, Academic Hospital Research Center, Federal University of Rio Grande do Sul, 90035-903 Porto Alegre, RS, Brazil
- Childreńs Cancer Institute, 90420-140 Porto Alegre, RS, Brazil
- Corresponding author at: Cancer Research Laboratory, Children's Cancer Institute, R. Ramiro Barcelos 2350, 3° Leste, 90035-903 Porto Alegre, RS, Brazil. Tel.: +55 51 2102 7616; fax: +55 51 3388-2877.

Received 8 May 2008; received in revised form 8 May 2008; accepted 3 July 2008. published online 07 March 2011.

Abstract

Sodium butyrate (NaB), a potent histone deacetylase inhibitor, induces cell cycle arrest and apoptosis in malignant cells. We investigated the effects on cellular proliferation in vitro when combining NaB with antineoplastic drugs commonly used to treat leukemias. Our results demonstrate that NaB increases the cytotoxic effects of cytarabine and etoposide, but not of bleomycin, doxorubicin, vincristine or methotrexate. These data suggest that NaB is a promising adjuvant therapeutic agent for the treatment of lymphoblastic leukemias, and provides a basis for further studies in this field.

Keywords: Acute lymphoblastic leukemia, Sodium butyrate, Adjuvant therapy, Chemotherapy