Leukemia Research
Volume 32, Issue 2 , Pages 269-273 , February 2008

The morphological subcategories of acute monocytic leukemia (M5a and M5b) share similar immunophenotypic and cytogenetic features and clinical outcomes

  • Pierre Villeneuve

      Affiliations

    • Department of Laboratory Hematology, University Health Network, University of Toronto, Toronto, Canada
    • ,
  • Dae Tong Kim

      Affiliations

    • Department of Laboratory Hematology, University Health Network, University of Toronto, Toronto, Canada
    • ,
  • Wei Xu

      Affiliations

    • Department of Biomedical Statistics, University Health Network, University of Toronto, Toronto, Canada
    • ,
  • Joseph Brandwein

      Affiliations

    • Department of Medical Oncology, University Health Network, University of Toronto, Toronto, Canada
    • ,
  • Hong Chang

      Affiliations

    • Department of Laboratory Hematology, University Health Network, University of Toronto, Toronto, Canada
    • Corresponding Author InformationCorresponding author at: Department of Laboratory Hematology, 200 Elizabeth Street, 11E-413, Toronto General Hospital, University Health Network, Toronto M5G 2C4, Canada. Tel.: +1 416 340 4858; fax: +1 416 340 5543.

Received 13 April 2007 ,Revised 5 June 2007 ,Accepted 6 June 2007.

References 

  1. Bennett JM, Catovsky D, Daniel MT, et al. Proposed revised criteria for the classification of acute myeloid leukemia A report of the French-American-British cooperative group. Ann Intern Med. 1985;103:620–625
  2. Jaffe ES, N.L. H, Stein H, Vardiman JW. Pathology and genetics. World Health Organization of tumours, tumours or haematopoietic and lymphoid tissues. Lyon: IARC Press; 2001;
  3. Chang H, Brandwein J, Yi QL, Chun K, Patterson B, Brien B, et al. Extramedullary infiltrates of AML are associated with CD56 expression 11q23 abnormalities and inferior clinical outcome. Leuk Res. 2004;28:1007–1011
  4. Chang H, Salma F, Yi QL, Patterson B, Brien B, Minden MD, et al. Prognostic relevance of immunophenotyping in 379 patients with acute myeloid leukemia. Leuk Res. 2004;28:43–48
  5. Haferlach T, Schoch C, Schnittger S, Kern W, Loffler H, Hiddemann W, et al. Distinct genetic patterns can be identified in acute monoblastic and acute monocytic leukaemia (FAB AML M5a and M5b): a study of 124 patients. Br J Haematol. 2002;118:426–431
  6. Schoch C, Schnittger S, Klaus M, Kern W, Hiddemann W, Haferlach T, et al. AML with 11q23/MLL abnormalities as defined by the WHO classification: incidence, partner chromosomes, FAB subtype, age distribution, and prognostic impact in an unselected series of 1897 cytogenetically analyzed AML cases. Blood. 2003;102:2395–2402
  7. Thiede C, Steudel C, Mohr B, et al. Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis. Blood. 2002;99:4326–4335
  8. Tallman MS, Kim HT, Paietta E, et al. Acute monocytic leukemia (French-American-British classification M5) does not have a worse prognosis than other subtypes of acute myeloid leukemia: a report from the Eastern cooperative oncology group. J Clin Oncol. 2004;22:1276–1286
  9. Byrd JC, Mrozek K, Dodge RK, et al. Pretreatment cytogenetic abnormalities are predictive of induction success, cumulative incidence of relapse, and overall survival in adult patients with de novo acute myeloid leukemia: results from cancer and leukemia group B (CALGB 8461). Blood. 2002;100:4325–4336

PII: S0145-2126(07)00252-4

doi: 10.1016/j.leukres.2007.06.019

Leukemia Research
Volume 32, Issue 2 , Pages 269-273 , February 2008

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