Leukemia Research
Volume 30, Issue 9 , Pages 1085-1089 , September 2006

PTPN11, RAS and FLT3 mutations in childhood acute lymphoblastic leukemia

  • Tomoko Yamamoto

      Affiliations

    • Departments of Pediatrics Nagoya University Graduate School of Medicine, Nagoya, Japan
    • Corresponding Author InformationCorresponding author at: Department of Pediatrics, Nagoya University Graduate School of Medicine 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan. Tel.: +81 52 744 2294; fax: +81 52 744 2974.
    • ,
  • Mariko Isomura

      Affiliations

    • Departments of Pediatrics Nagoya University Graduate School of Medicine, Nagoya, Japan
    • ,
  • Yinyan Xu

      Affiliations

    • Departments of Pediatrics Nagoya University Graduate School of Medicine, Nagoya, Japan
    • ,
  • Juan Liang

      Affiliations

    • Departments of Pediatrics Nagoya University Graduate School of Medicine, Nagoya, Japan
    • ,
  • Hiroshi Yagasaki

      Affiliations

    • Departments of Pediatrics Nagoya University Graduate School of Medicine, Nagoya, Japan
    • ,
  • Yoshiro Kamachi

      Affiliations

    • Departments of Pediatrics Nagoya University Graduate School of Medicine, Nagoya, Japan
    • ,
  • Kazuko Kudo

      Affiliations

    • Departments of Pediatrics Nagoya University Graduate School of Medicine, Nagoya, Japan
    • ,
  • Hitoshi Kiyoi

      Affiliations

    • Departments of Infectious Disease, Nagoya University Graduate School of Medicine, Nagoya, Japan
    • ,
  • Tomoki Naoe

      Affiliations

    • Departments of Hematology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    • ,
  • Seiji Kojma

      Affiliations

    • Departments of Pediatrics Nagoya University Graduate School of Medicine, Nagoya, Japan

Received 7 July 2005 ,Revised 31 January 2006 ,Accepted 2 February 2006.

References 

  1. Dechert U, Duncan AM, Bastien L, Duff C, Adam M, Jirik FR. Protein-tyrosine phosphatase SH-PTP2(PTPN11) is localized to 12q24.1-24.3. Hum Genet. 1995;96:609–615
  2. Neel BG, Gu H, Pao L. The ‘Shp’ing news: SH2 domain-containing thyrosine phosphatases in cell signaling. Trends Biochem Sci. 2003;28:284–293
  3. Tartaglia M, Mehler EL, Goldberg R, et al. Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome. Nat Genet. 2001;29:465–468
  4. Tartaglia M, Niemeyer CM, Fragale A, et al. Somatic mutations in PTPN11 in juvenile myelomonocytic leukemia, myelodysplastic syndrome and acute myeloid leukemia. Nat Genet. 2003;34:148–150
  5. Loh ML, Vattikuti S, Schubbert S, et al. Mutations in PTPN11 implicate the SHP-2 phosphatase in leukemogenesis. Blood. 2004;103:2325–2331
  6. Tartaglia M, Martinelli S, Cazzaniga G, et al. Genetic evidence for lineage-related and differentiation stage-related contribution of somatic PTPN11 mutations to leukomogenesis in childhood acute leukemia. Blood. 2004;104:307–313
  7. Tartaglia M, Kalidas K, Shaw A, et al. PTPN11 mutations in Noonan syndrome: molecular spectrum, genotype–phenotype correlation, and phenotypic heterogeneity. Am J Hum Genet. 2002;70:1555–1563
  8. Kubo K, Naoe T, Kiyoi H, et al. Clonal analysis of multiple point mutations in the N-ras gene in patients with acute myeloid leukemia. Jpn J Cancer Res. 1993;84:379–387
  9. Kiyoi H, Naoe T, Yokota S, et al. Leukemia study group of the Ministry of Health and Welfare (Kohseisho). Internal tandem duplication of FLT3 associated with leukocytosis in acute promyelocytic leukemia. Leukemia. 1997;11:1447–1452
  10. Yamamoto Y, Kiyoi H, Nakano Y, et al. Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies. Blood. 2001;97:2434–2439
  11. Kratz CP, Niemeyer CM, Castleberry RP, et al. The mutational spectrum of PTPN11 in juvenile myelomonocytic leukemia and Noonan syndrome/myeloproliferative disease. Blood. 2005;106:2183–2185
  12. Mohi MG, Williams IR, Dearolf CR, et al. Prognostic, therapeutic, and mechanistic implications of a mouse model of leukemia evoked by Shp2 (PTPN11) mutations. Cancer Cell. 2005;7:179–191
  13. Wechsler J, Greene M, McDevitt MA, et al. Acquired mutations in GATA1 in the megakaryoblastic leykemia of Down syndrome. Nat Genet. 2002;32:148–152
  14. Johan MF, Bowen DT, Frew ME, et al. Mutations in PTPN11 are uncommon in adult myelodysplastic syndrome and acute myeloid leukemia. Brit J Haematol. 2004;124:843–844
  15. Watkins F, Fidler C, Boultwood J, Wainscoat JS. Mutations in PTPN11 are rare in adult myelodysplastic syndromes and acute myeloid leukemia. Am J Hematol. 2004;76:417
  16. Loh ML, Martinelli S, Cordeddu V, et al. Acquired PTPN11 mutations occur rarely in adult patients with myelodysplastic syndromes and chronic myelomonocytic leukemia. Leukemia Res. 2005;29:459–462
  17. Bos JL. ras oncogene in human cancer: a review. Cancer Res. 1989;49:4682–4689
  18. Rodenhuis S, Bos JL, Slater RM, Behrendt H, van’t Veer M, Smets LA. Absence of oncogene amplifications and occasional activation of N-ras in lymphoblastic leukemia of childhood. Blood. 1986;67:1698–1704
  19. Neri A, Knowles DM, Greco A, McCormick F, Dalla-Favera R. Analysis of RAS oncogene mutation in human lymphoid malignancies. Proc Natl Acad Sci USA. 1988;85:9268–9272
  20. Bar-Eli M, Ahuja H, Foti A, Celine MJ. N-RAS mutations in T-cell acute lymphocytic leukemia: analysis by direct sequencing detects a novel mutation. Brit J Haematol. 1989;72:36–39
  21. Yokota S, Nakao M, Horiike S, et al. Mutational analysis of the N-ras gene in acute lymphoblastic leukemia: a study of 125 Japanese pediatrics cases. Int J Hematol. 1998;67:379–387
  22. Lubbert M, Mirro J, Miller CW, et al. N-ras gene point mutations in childhood acute lymphoblastic leukemia correlate with a poor prognosis. Blood. 1990;75:1163–1169
  23. Ahuja HG, Foti A, Bar-Eli M, Cline MJ. The pattern of mutational involvement of RAS genes in human hematologic malignancies determined by DNA amplification and direct sequencing. Blood. 1990;75:1684–1690
  24. Perentesis JP, Bhatia S, Boyle E, et al. RAS oncogene mutations and outcome of therapy for childhood acute lymphoblastic leukemia. Leukemia. 2004;18:685–692
  25. Wiemels JL, Zhang Y, Chang J, et al. RAS mutation is associated with hyperdiploidy and parental characteristics in pediatric acute lymphoblastic leukemia. Leukemia. 2005;19:415–419
  26. Gilliland DG, Griffin JD. The roles of FLT3 in hematopoiesis and leukemia. Blood. 2002;100:1532–1542
  27. Nakao M, Yokota S, Iwai T, et al. Internal tandem duplication of the flt3 gene found in acute myeloid leukemia. Leukemia. 1996;10:1911–1918
  28. Levis M, Small D. FLT3: ITDoes matter in leukemia. Leukemia. 2003;17:1738–1752
  29. Taketani T, Taki T, Sugita K, et al. FLT3 mutations in the activation loop of tyrosine kinase domain are frequently found in infant ALL with MLL rearrangements and pediatric ALL with hyperdiploidy. Blood. 2004;103:1085–1088
  30. Armstrong SA, Mabon ME, Silverman LB, et al. FLT3 mutations in childhood acute lymphoblastic leukemia. Blood. 2004;103:3544–3546
  31. Loh ML, Reynolds MG, Vattikuti S, et al. PTPN11 mutations in pediatric patients with acute myeloid leukemia: results from the Children's Cancer Group. Leukemia. 2004;18:1831–1834

PII: S0145-2126(06)00062-2

doi: 10.1016/j.leukres.2006.02.004

Leukemia Research
Volume 30, Issue 9 , Pages 1085-1089 , September 2006

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