Leukemia Research
Volume 30, Issue 12 , Pages 1517-1520 , December 2006

Low dose antithymocyte globulin for the treatment of older patients with aplastic anaemia

  • S.B. Killick

      Affiliations

    • Department of Haematology, Royal Bournemouth Hospital, Castle Lane East, Bournemouth BH7 7DW, UK
    • Corresponding Author InformationCorresponding author. Tel.: +44 1202 704783; fax: +44 1202 300248.
    • ,
  • J.D. Cavenagh

      Affiliations

    • Department of Haematology, St. Bartholomew's and The Royal London Hospitals, UK
    • ,
  • J.K. Davies

      Affiliations

    • Department of Haematology, St. Bartholomew's and The Royal London Hospitals, UK
    • ,
  • J.C.W. Marsh

      Affiliations

    • Department of Haematology, St. George's Hospital and St. George's University of London, UK

Received 1 February 2006 ,Revised 1 February 2006 ,Accepted 2 February 2006.

References 

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  2. Fuhrer M, Rampf U, Baumann I, Faldum A, Niemeyer C, Janka-Schaub G, et al. Immunosuppressive therapy for aplastic anemia in children: a more severe disease predicts better survival. Blood. 2005;106:2102–2104
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  5. Killick SB, Mufti G, Cavenagh JD, Mijovic A, Peacock JL, Gordon-Smith EC, et al. A pilot study of antithymocyte globulin (ATG) in the treatment of patients with ‘low-risk’ myelodysplasia. Br J Haematol. 2003;120(4):679–684
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  7. Tichelli A, Socie G, Henry-Amar M, Marsh J, Passweg J, Schrezenmeier H, et al. Effectiveness of immunosuppressive therapy in older patients with aplastic anemia. Ann Intern Med. 1999;130:193–201
  8. Killick SB, Marsh JCW, Gordon-Smith EC, Sorlin L, Gibson FM. Effects of antithymocyte globulin on bone marrow CD34+ cells in aplastic anaemia and myelodysplasia. Br J Haematol. 2000;108:582–591
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  10. Bacigalupo A, Hows J, Gluckman E, Nissen C, Marsh J, Van Lint MT, et al. Bone marrow transplantation (BMT) versus immunosuppression for the treatment of severe aplastic anaemia (SAA): a report of the EBMT SAA working party. Br J Haematol. 1988;70:177–182
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  14. Steensma DP, Dispenzieri A, Moore SB, Schroeder G, Tefferi A. Antithymocyte globulin has limited efficacy and substantial toxicity in unselected anemic patients with myelodysplastic syndrome. Blood. 2003;101:2156–2158
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  21. Killick SB, Cox CV, Marsh JCW, Gordon-Smith EC, Gibson FM. Mechanisms of bone marrow progenitor cell apoptosis in aplastic anaemia and the effect of anti-thymocyte globulin: examination of the role of the Fas–Fas-L interaction. Br J Haematol. 2000;111:1164–1169
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  24. Flynn J, Cox CV, Rizzo S, Foukanelli T, Rice K, Murphy M, et al. Direct binding of antithymocyte globulin to haemopoietic progenitor cells in aplastic anaemia. Br J Haematol. 2003;122:289–297
  25. Genestier L, Fournet S, Flacher M, Assossou O, Revillard J-P, Bonnefoy-Berard N. Induction of Fas (Apo-1, CD95)-mediated apoptosis of activated lymphocytes by polyclonal antithymocyte globulins. Blood. 1998;91:2360–2368
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PII: S0145-2126(06)00061-0

doi: 10.1016/j.leukres.2006.02.003

Leukemia Research
Volume 30, Issue 12 , Pages 1517-1520 , December 2006

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