Leukemia Research
Volume 30, Issue 9 , Pages 1065-1066 , September 2006

Ig and TCR gene rearrangements in childhood ALL: Is there ethnic and socio-economic diversity of rearrangement patterns?

  • Carlos Alberto Scrideli

      Affiliations

    • Corresponding Author InformationCorresponding author at: Departamento de Pediatria, Faculdade de Medicina de Ribeirao Preto, Universidade de São Paulo, Avenida Bandeirantes 3900, 14048-900 Ribeirão Preto-SP, Brazil. Tel.: +55 16 3602 2672; fax: +55 16 3602 2700.
    • ,
  • Luiz Gonzaga Tone

Received 27 January 2006

References 

  1. Dawidowiska M, Derwich K, Szczepanski T, Jolkowska J, van der Velden VHJ, Wachowiak J, et al. Pattern of immunoglobulin and T-cell receptor (Ig/TCR) gene rearrangements in Polish pediatric acute lymphoblastic leukemia patients—Implications for RQ-PCR-based assessment of minimal residual disease. Leuk Res. 2006;30:1119–1125
  2. Szczepanski T, Beishuizen A, Pongers-Willemse MJ, Hahlen K, Van Wering ER, Wijkhuijs AJ, et al. Cross-lineage T cell receptor gene rearrangements occur in more than ninety percent of childhood precursor-B acute lymphoblastic leukemias: alternative PCR targets for detection of minimal residual disease. Leukemia. 1999;13(2):196–205
  3. van Dongen JJ, Langerak AW, Bruggemann M, Evans PA, Hummel M, Lavender FL, et al. Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936. Leukemia. 2003;17(12):2257–2317
  4. Eckert C, Scrideli CA, Taube T, Songia S, Wellmann S, Manenti M, et al. Comparison between TaqMan and LightCycler technologies for quantification of minimal residual disease by using immunoglobulin and T-cell receptor genes consensus probes. Leukemia. 2003;17(12):2517–2524
  5. Cazzaniga G, Biondi A. Molecular monitoring of childhood acute lymphoblastic leukemia using antigen receptor gene rearrangements and quantitative polymerase chain reaction technology. Haematologica. 2005;90(3):382–390
  6. Pongers-Willemse MJ, Seriu T, Stolz F, d’Aniello E, Gameiro P, Pisa P, et al. Primers and protocols for standardized detection of minimal residual disease in acute lymphoblastic leukemia using immunoglobulin and T cell receptor gene rearrangements and TAL1 deletions as PCR targets: report of the BIOMED-1 CONCERTED ACTION: investigation of minimal residual disease in acute leukemia. Leukemia. 1999;13(1):110–118
  7. van der Velden VH, Szczepanski T, Wijkhuijs JM, Hart PG, Hoogeveen PG, Hop WC, et al. Age-related patterns of immunoglobulin and T-cell receptor gene rearrangements in precursor-B-ALL: implications for detection of minimal residual disease. Leukemia. 2003;17(9):1834–1844
  8. Brumpt C, Delabesse E, Beldjord K, Davi F, Cayuela JM, Millien C, et al. The incidence of clonal T-cell receptor rearrangements in B-cell precursor acute lymphoblastic leukemia varies with age and genotype. Blood. 2000;96(6):2254–2261
  9. Hubner S, Cazzaniga G, Flohr T, van der Velden VH, Konrad M, Potschger U, et al. High incidence and unique features of antigen receptor gene rearrangements in TEL-AML1-positive leukemias. Leukemia. 2004;18(1):84–91
  10. Scrideli CA, Queiroz RG, Kashima S, Sankarankutty BO, Tone LG. T cell receptor gamma (TCRG) gene rearrangements in Brazilian children with acute lymphoblastic leukemia: analysis and implications for the study of minimal residual disease. Leuk Res. 2004;28(3):267–273
  11. Nirmala K, Rajalekshmy KR, Raman SG, Shanta V, Rajkumar T. PCR-heteroduplex analysis of TCR gamma, delta and TAL-1 deletions in T-acute lymphoblastic leukemias: implications in the detection of minimal residual disease. Leuk Res. 2002;26(4):335–343
  12. Szczepanski T, Langerak AW, Willemse MJ, Wolvers-Tettero IL, van Wering ER, van Dongen JJ. T cell receptor gamma (TCRG) gene rearrangements in T cell acute lymphoblastic leukemia refelct ‘end-stage’ recombinations: implications for minimal residual disease monitoring. Leukemia. 2000;14(7):1208–1214
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PII: S0145-2126(06)00048-8

doi: 10.1016/j.leukres.2006.01.012

Leukemia Research
Volume 30, Issue 9 , Pages 1065-1066 , September 2006

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