Leukemia Research
Volume 30, Issue 9 , Pages 1135-1139 , September 2006

Infrequent Wnt inhibitory factor-1 (Wif-1) methylation in chronic lymphocytic leukemia

  • C.S. Chim

      Affiliations

    • Department of Medicine, Queen Mary Hospital, University of Hong Kong, Pokfulam Road, Hong Kong
    • Corresponding Author InformationCorresponding author. Tel.: +852 28555859; fax: +852 29741165.
    • ,
  • T.K. Fung

      Affiliations

    • Department of Medicine, Queen Mary Hospital, University of Hong Kong, Pokfulam Road, Hong Kong
    • ,
  • K.F. Wong

      Affiliations

    • Department of Pathology, Queen Elizabeth Hospital, Hong Kong
    • ,
  • J.S. Lau

      Affiliations

    • Department of Medicine, Queen Elizabeth Hospital, Hong Kong
    • ,
  • R. Liang

      Affiliations

    • Department of Medicine, Queen Mary Hospital, University of Hong Kong, Pokfulam Road, Hong Kong

Received 12 October 2005 ,Revised 11 December 2005 ,Accepted 14 December 2005.

Reference 

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  2. Kawano Y, Kypta R. Secreted antagonists of the Wnt signalling pathway. J Cell Sci. 2003;116(Part 13):2627–2634
  3. Hsieh JC, Kodjabachian L, Rebbert ML, Rattner A, Smallwood PM, Samos CH, et al. A new secreted protein that binds to Wnt proteins and inhibits their activities. Nature. 1999;398(6726):431–436
  4. Herman JG, Baylin SB. Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med. 2003;349(21):2042–2054
  5. Chim CS, Liang R, Kwong YL. Gene promoter hypermethylation in hematologic malignancies. Hematol Oncol. 2002;20:167–176
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  10. Cheson BD, Bennett JM, Grever M, Kay N, Keating MJ, O’Brien S, et al. National Cancer Institute-sponsored Working Group guidelines for chronic lymphocytic leukemia: revised guidelines for diagnosis and treatment. Blood. 1996;87:4990–4997
  11. Ma SY, Au WY, Chim CS, Lie AK, Lam CC, Tse E, et al. Fludarabine, mitoxantrone and dexamethasone in the treatment of indolent B- and T-cell lymphoid malignancies in Chinese patients. Br J Haematol. 2004;124:754–761
  12. Chim CS, Liang R, Tam C, Kwong YL. P15 and P16 promoter methylation in acute promyelocytic leukemia. J Clin Oncol. 2001;19:2033–2040
  13. Chim CS, Fung TK, Cheung J, Liang R, Kwong YL. SOCS1 and SHP1 hypermethylation in multiple myeloma: implications for epigenetic activation of the Jak/STAT pathway. Blood. 2004;103(12):4630–4635
  14. Mazieres J, He B, You L, Xu Z, Lee AY, Mikami I, et al. Wnt inhibitory factor-1 is silenced by promoter hypermethylation in human lung cancer. Cancer Res. 2004;64(14):4717–4720
  15. Roman-Gomez J, Jimenez-Velasco A, Agirre X, Castillejo JA, Navarro G, Barrios M, et al. Transcriptional silencing of the Dickkopfs-3 (Dkk-3) gene by CpG hypermethylation in acute lymphoblastic leukaemia. Br J Cancer. 2004;91(4):707–713
  16. Issa JP, Ottaviano YL, Celano P, Hamilton SR, Davidson NE, Baylin SB. Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon. Nat Genet. 1994;7(4):536–540

PII: S0145-2126(05)00477-7

doi: 10.1016/j.leukres.2005.12.005

Leukemia Research
Volume 30, Issue 9 , Pages 1135-1139 , September 2006

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