Leukemia Research
Volume 30, Issue 9 , Pages 1135-1139, September 2006

Infrequent Wnt inhibitory factor-1 (Wif-1) methylation in chronic lymphocytic leukemia

  • C.S. Chim

      Affiliations

    • Department of Medicine, Queen Mary Hospital, University of Hong Kong, Pokfulam Road, Hong Kong
    • Corresponding Author InformationCorresponding author. Tel.: +852 28555859; fax: +852 29741165.
    • ,
  • T.K. Fung

      Affiliations

    • Department of Medicine, Queen Mary Hospital, University of Hong Kong, Pokfulam Road, Hong Kong
    • ,
  • K.F. Wong

      Affiliations

    • Department of Pathology, Queen Elizabeth Hospital, Hong Kong
    • ,
  • J.S. Lau

      Affiliations

    • Department of Medicine, Queen Elizabeth Hospital, Hong Kong
    • ,
  • R. Liang

      Affiliations

    • Department of Medicine, Queen Mary Hospital, University of Hong Kong, Pokfulam Road, Hong Kong

Received 12 October 2005; received in revised form 11 December 2005; accepted 14 December 2005. published online 07 March 2011.

Abstract 

The Wnt pathway has been shown recently, to be activated in patients with chronic lymphocytic leukemia (CLL). This is the first study to examine the role of Wnt inhibitory factor-1 (Wif-1) methylation in the pathogenesis of haematolymphoid malignancies. Wif-1, a putative tumor suppressor, is a soluble negative regulator of the Wnt pathway activated in CLL. We studied the role of methylation of Wif-1 in 43 Chinese patients with CLL. At diagnosis, Wif-1 methylation was detected in 5/43 (11.6%) CLL marrow samples. Wif-1 methylation occurred more frequently in patients with advanced age (p=0.059) but there was no correlation between Wif-1 methylation and sex, lymphocyte count and Rai stage at diagnosis. In conclusion, Wif-1 is infrequently methylated in CLL. Other factors leading to activation of the Wnt pathway warrant further study.

Keywords: Wif-1, Methylation, CLL, Chinese

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PII: S0145-2126(05)00477-7

doi:10.1016/j.leukres.2005.12.005

Leukemia Research
Volume 30, Issue 9 , Pages 1135-1139, September 2006

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