Leukemia Research
Volume 30, Issue 9 , Pages 1063-1064 , September 2006

Is chronic lymphocytic leukemia a response to infectious agents?

  • Terry Hamblin

      Affiliations

    • Corresponding Author InformationTel.: +44 1202 267154; fax: +44 1202 300248.

References 

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  3. Tobin G, Thunberg U, Johnson A, Thorn I, Soderberg O, Hultdin M, et al. Somatically mutated IgVH3-21 genes characterize a new subset of chronic lymphocytic leukemia. Blood. 2002;99:2262–2264
  4. Damle RN, Wasil T, Fais F, Ghiotto F, Valetto A, Allen SL, et al. Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia. Blood. 1999;94:1840–1847
  5. Hamblin TJ, Davis Z, Gardiner A, Oscier DG, Stevenson FK. Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood. 1999;94:1848–1854
  6. Tobin G, Thunberg U, Johnson A, Eriksson I, Soderberg O, Karlsson K, et al. Chronic lymphocytic leukemias utilizing the VH3-21 gene display highly restricted V lambda 2-14 gene use and homologous CDR3s: implicating recognition of a common antigen epitope. Blood. 2003;101:4952–4957
  7. Chiorazzi N, Ferrarini M. B cell chronic lymphocytic leukemia: lessons learned from studies of the B cell antigen receptor. Annu Rev Immunol. 2003;21:841–894
  8. Messmer BT, Albesiano E, Efremov DG, Ghiotto F, Allen SL, Kolitz J, et al. Multiple distinct sets of stereotyped antigen receptors indicate a role for antigen in promoting chronic lymphocytic leukemia. J Exp Med. 2004;200:519–525
  9. Tobin G, Thunberg U, Karlsson K, Murray F, Laurell A, Willander K, et al. Subsets with restricted immunoglobulin gene rearrangement features indicate a role for antigen selection in the development of chronic lymphocytic leukemia. Blood. 2004;104:2879–2885
  10. Capello D, Zucchetto A, Degan M, Bomben R, Dal Bo M, Efremov DG, et al. Immunophenotypic characterization of IgVH3-72 B-cell chronic lymphocytic leukemia (B-CLL). Leuk Res. 2006;30:1197–1199
  11. Herve M, Xu K, Ng YS, Wardemann H, Albesiano E, Messmer BT, et al. Unmutated and mutated chronic lymphocytic leukemias derive from self-reactive B cell precursors despite expressing different antibody reactivity. J Clin Invest. 2005;115:1636–1643
  12. Potter KN, Hobby P, Klijn S, Stevenson FK, Sutton BJ. Evidence for involvement of a hydrophobic patch in framework region 1 of human V4-34-encoded Igs in recognition of the red blood cell I antigen. J Immunol. 2002;1697:3777–3782

PII: S0145-2126(05)00468-6

doi: 10.1016/j.leukres.2005.11.022

Leukemia Research
Volume 30, Issue 9 , Pages 1063-1064 , September 2006

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