Leukemia Research
Volume 30, Issue 6 , Pages 651-652, June 2006

Defining the role of gene regulation in resistance to HDAC inhibitors—Mechanisms beyond P-glycoprotein

Cancer Research, R47J-AP9, Abbott Laboratories, Abbott Park, IL 60064-6121, United States

Received 27 October 2005 published online 07 March 2011.

Abstract 

The manuscript by Yamada et al. “Depsipeptide-resistant KU812 cells show reversible P-glycoprotein expression, hyperacetylated histones, and modulated gene expression profile,” describes not only development of the major resistance mechanism, P-glycoprotein expression, but how histone deacetylase inhibitors can modulate the gene expression profile to promote survival and resistance to depsipeptide.

Keywords: Depsipeptide, Histone deacetylase, HDAC inhibitor, Expression profiling, P-glycoprotein

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PII: S0145-2126(05)00415-7

doi:10.1016/j.leukres.2005.10.016

Leukemia Research
Volume 30, Issue 6 , Pages 651-652, June 2006

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