Leukemia Research
Volume 30, Issue 6 , Pages 695-699 , June 2006

Korean patients with chronic lymphocytic leukemia show the similar types of chromosomal aberrations as those in Europe and North America

  • Yoon Hwan Chang

      Affiliations

    • Department of Laboratory Medicine, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul, Republic of Korea
    • ,
  • Junwan Park

      Affiliations

    • Department of Laboratory Medicine, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul 110-744, Republic of Korea
    • ,
  • Hee Chan Kim

      Affiliations

    • Department of Biomedical Engineering, Seoul National University College of Medicine, Seoul, Republic of Korea
    • ,
  • Hong Ku Chun

      Affiliations

    • Department of Biomedical Engineering, Seoul National University College of Medicine, Seoul, Republic of Korea
    • ,
  • Young Ree Kim

      Affiliations

    • Department of Laboratory Medicine, Cheju National University College of Medicine, Jeju, Republic of Korea
    • ,
  • Myungshin Kim

      Affiliations

    • Department of Clinical Pathology, The Catholic University of Korea College of Medicine, Seoul, Republic of Korea
    • ,
  • Kyungja Han

      Affiliations

    • Department of Clinical Pathology, The Catholic University of Korea College of Medicine, Seoul, Republic of Korea
    • ,
  • Je-Hwan Lee

      Affiliations

    • Section of Hematology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea
    • ,
  • Kyoo-Hyung Lee

      Affiliations

    • Section of Hematology, Department of Internal Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea
    • ,
  • Han Ik Cho

      Affiliations

    • Department of Laboratory Medicine, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul 110-744, Republic of Korea
    • ,
  • Yun Song Lee

      Affiliations

    • Division of Pharmacology, Department of Molecular & Cellular Biology, Sungkyunkwan University School of Medicine, 300 Chunchun-dong, Jangan-gu, Suwon-si, Gyeonggi-do 440-746, Republic of Korea
    • Corresponding Author InformationCorresponding author. Tel.: +82 31 299 6190; fax: +82 31 299 6209.
    • ,
  • Dong Soon Lee

      Affiliations

    • Department of Laboratory Medicine, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul 110-744, Republic of Korea
    • Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea
    • National Research Laboratory for Molecular Cell Imaging, Seoul, Republic of Korea
    • Corresponding Author InformationCorresponding author. Tel.: +82 2 2072 3986; fax: +82 2 747 0359.

Received 5 June 2005

References 

  1. Müller-Hermelink HK, Montserrat E, Catovsky D, Harris NL. Chronic lymphocytic leukaemia/small lymphocytic lymphoma. In:  Jaffe ES,  Harris NL,  Stein H,  Vardiman JW editor. Pathology and genetics of tumours of the haematopoietic and lymphoid tissues. World Health Organization classification of tumours: pathology and genetics. Lyon: IARC Press; 2001;p. 127–130
  2. Chena C, Arrossagaray G, Scolnik M, Palacios MF, Slavutsky I. Interphase cytogenetic analysis in Argentinean B-cell chronic lymphocytic leukemia patients: association of trisomy 12 and del(13q14). Cancer Genet Cytogenet. 2003;146:154–160
  3. Ahn YO, Koo HH, Park BJ, Yoo KY, Lee MS. Incidence estimation of leukemia among Koreans. J Korean Med Sci. 1991;6:299–307
  4. Cho D, Hong WP, Kim HJ, Ryang DW. A case of chronic lymphocytic leukemia with trisomy 12 detected by fluorescence in situ hybridization. Korean J Clin Pathol. 1997;17:689–693
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  6. In:  Mitelman F editors. ISCN: An International System for Human Cytogenetic Nomenclature. Basel: S. Karger; 1995;
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  8. Stilgenbauer S, Lichter P, Döhner H. Genetic features of B-cell chronic lymphocytic leukemia. Rev Clin Exp Hematol. 2000;4:48–72
  9. Liu Y, Hermanson M, Grandér D, Merup M, Wu X, Heyman M, et al. 13q deletions in lymphoid malignancies. Blood. 1995;86:1911–1915
  10. Tricot G, Barlogie B, Jagannath S, Bracy D, Mattox S, Vesole DH, et al. Poor prognosis in multiple myeloma is associated only with partial or complete deletions of chromosome 13 or abnormalities involving 11q and not with other karyotype abnormalities. Blood. 1995;86:4250–4256
  11. Gahrton G, Robert KH, Friberg K, Zech L, Bird AG. Nonrandom chromosomal aberrations in chronic lymphocytic leukemia revealed by polyclonal B-cell-mitogen stimulation. Blood. 1980;56:640–647
  12. Dierlamm J, Michaux L, Criel A, Wlodarska I, Van den Berghe H, Hossfeld DK. Genetic abnormalities in chronic lymphocytic leukemia and their clinical and prognostic implications. Cancer Genet Cytogenet. 1997;94:27–35
  13. Mould S, Gardiner A, Corcoran M, Oscier DG. Trisomy 12 and structural abnormalities of 13q14 occurring in the same clone in chronic lymphocytic leukaemia. Br J Haematol. 1996;92:389–392
  14. Cuneo A, Bigoni R, Rigolin GM, Roberti MG, Bardi A, Cavazzini F, et al. Late appearance of the 11q22.3–23.1 deletion involving the ATM locus in B-cell chronic lymphocytic leukemia and related disorders. Clinico-biological significance. Haematologica. 2002;87:44–51
  15. Döhner H, Stilgenbauer S, James MR, Benner A, Weilguni T, Bentz M, et al. 11q deletions identify a new subset of B-cell chronic lymphocytic leukemia characterized by extensive nodal involvement and inferior prognosis. Blood. 1997;89:2516–2522
  16. Montserrat E, Rozman C. Chronic lymphocytic leukemia: present status. Ann Oncol. 1995;6:219–235
  17. Arif M, Tanaka K, Asou H, Ohno R, Kamada N. Independent clones of trisomy 12 and retinoblastoma gene deletion in Japanese B cell chronic lymphocytic leukemia, detected by fluorescence in situ hybridisation. Leukemia. 1995;9:1822–1827
  18. Glassman AB, Hayes KJ. The value of fluorescence in situ hybridization in the diagnosis and prognosis of chronic lymphocytic leukaemia. Cancer Genet Cytogenet. 2005;158:88–91

PII: S0145-2126(05)00399-1

doi: 10.1016/j.leukres.2005.10.013

Leukemia Research
Volume 30, Issue 6 , Pages 695-699 , June 2006

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