Leukemia Research
Volume 30, Issue 4 , Pages 483-485 , April 2006

The effect of the Hyper-CVAD chemotherapy regimen on fertility and ovarian function

  • T. Seshadri

      Affiliations

    • Monash Medical Centre, Clayton, Vic. 3168, Australia
    • ,
  • M.J. Hourigan

      Affiliations

    • Princess Alexandra Hospital, Woolloongabba, Qld 4102, Australia
    • ,
  • M. Wolf

      Affiliations

    • Division of Haematology and Medical Oncology, Peter MacCallum Cancer Centre, St. Andrews Place, East Melbourne, Vic. 3002, Australia
    • ,
  • P.N. Mollee

      Affiliations

    • Princess Alexandra Hospital, Woolloongabba, Qld 4102, Australia
    • ,
  • J.F. Seymour

      Affiliations

    • Division of Haematology and Medical Oncology, Peter MacCallum Cancer Centre, St. Andrews Place, East Melbourne, Vic. 3002, Australia
    • Corresponding Author InformationCorresponding author. Tel.: 61 3 9656 1697; fax: 61 3 9656 1408.

Received 13 August 2005 ,Revised 15 August 2005 ,Accepted 15 August 2005.

References 

  1. Murphy SB, Bowman WP, Abromowitch M, et al. Results of the treatment of advanced-stage Burkitt's lymphoma and B cell (Sig+) acute lymphoblastic leukemia with high-dose fractionated cyclophosphamide and coordinated high-dose methotrexate and cytarabine. J Clin Oncol. 1986;4:1732–1739
  2. Kantarjian H, Thomas D, O’Brien S, et al. Long-term follow-up results of hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone (Hyper-CVAD), a dose-intensive regimen, in adult acute lymphocytic leukemia. Cancer. 2004;101(12):2788–2801
  3. Thomas DA, O’Brien S, Cortes J, et al. Outcome with the hyper-CVAD regimens in lymphoblastic lymphoma. Blood. 2004;104(6):1624–1630
  4. Khouri IF, Romaguera J, Kantarjian H, et al. Hyper-CVAD and high-dose methotrexate/cytarabine followed by stem-cell transplantation: an active regimen for aggressive mantle-cell lymphoma. J Clin Oncol. 1998;16(12):3803–3809
  5. Seymour JF. Ovarian tissue cryopreservation for cancer patients: who is appropriate?. Reprod Fertil Dev. 2001;13:81–89
  6. Micallef IN, Rohatiner AZ, Carter M, et al. Long-term outcome of patients surviving for more than ten years following treatment for acute leukaemia. Br J Haematol. 2001;113(2):443–445
  7. Dann EJ, Epelbaum R, Avivi I, et al. Fertility and ovarian function are preserved in women treated with an intensified regimen of cyclophosphamide, adriamycin, vincristine and prednisone (Mega-CHOP) for non-Hodgkin lymphoma. Hum Reprod. 2005;20(8):2247–2249Epub 2005 Apr 7
  8. Muller U, Stahel RA. Gonadal function after MACOP-B or VACOP-B with or without dose intensification and ABMT in young patients with aggressive non-Hodgkin's lymphoma. Ann Oncol. 1993;4(5):399–402

PII: S0145-2126(05)00324-3

doi: 10.1016/j.leukres.2005.08.014

Leukemia Research
Volume 30, Issue 4 , Pages 483-485 , April 2006

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