Leukemia Research
Volume 30, Issue 4 , Pages 483-485, April 2006

The effect of the Hyper-CVAD chemotherapy regimen on fertility and ovarian function

  • T. Seshadri

      Affiliations

    • Monash Medical Centre, Clayton, Vic. 3168, Australia
    • ,
  • M.J. Hourigan

      Affiliations

    • Princess Alexandra Hospital, Woolloongabba, Qld 4102, Australia
    • ,
  • M. Wolf

      Affiliations

    • Division of Haematology and Medical Oncology, Peter MacCallum Cancer Centre, St. Andrews Place, East Melbourne, Vic. 3002, Australia
    • ,
  • P.N. Mollee

      Affiliations

    • Princess Alexandra Hospital, Woolloongabba, Qld 4102, Australia
    • ,
  • J.F. Seymour

      Affiliations

    • Division of Haematology and Medical Oncology, Peter MacCallum Cancer Centre, St. Andrews Place, East Melbourne, Vic. 3002, Australia
    • Corresponding Author InformationCorresponding author. Tel.: 61 3 9656 1697; fax: 61 3 9656 1408.

Received 13 August 2005; received in revised form 15 August 2005; accepted 15 August 2005. published online 07 March 2011.

Abstract 

Hyper-CVAD is a dose intensive chemotherapy regimen that has been used successfully in lymphoblastic lymphoma and leukaemia. However, the effect on ovarian function has not been evaluated. Thus, we undertook a retrospective analysis of patients under 40 years of age who had Hyper-CVAD as initial therapy and documented ovarian function as defined by regular menstruation off hormonal agents or naturally conceiving. Of the 12 patients identified, 7 were evaluable. Median age was 25. Six patients had resumption of regular menstruation and three of these women have conceived naturally. In conclusion, resumption of normal fertility is probable post-treatment with Hyper-CVAD.

Keywords: Hyper-CVAD chemotherapy, Fertility, Ovarian function

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PII: S0145-2126(05)00324-3

doi:10.1016/j.leukres.2005.08.014

Leukemia Research
Volume 30, Issue 4 , Pages 483-485, April 2006

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