Leukemia Research
Volume 30, Issue 4 , Pages 477-481 , April 2006

The role of methylenetetrahydrofolate reductase in acute lymphoblastic leukemia in a Brazilian mixed population

  • Crisiane Wais Zanrosso

      Affiliations

    • Divisão de Medicina Experimental, Centro de Pesquisa, Instituto Nacional de Câncer, Rua André Cavalcanti, 37, CEP 20231-050 Rio de Janeiro, Brazil
    • ,
  • Ana Hatagima

      Affiliations

    • Departamento de Genética, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil
    • ,
  • Mariana Emerenciano

      Affiliations

    • Divisão de Medicina Experimental, Centro de Pesquisa, Instituto Nacional de Câncer, Rua André Cavalcanti, 37, CEP 20231-050 Rio de Janeiro, Brazil
    • ,
  • Flávio Ramos

      Affiliations

    • Divisão de Biologia Molecular do Departamento de Biologia do ICB-UPE, Recife, Pernambuco, Brazil
    • ,
  • Alexandre Figueiredo

      Affiliations

    • Divisão de Medicina Experimental, Centro de Pesquisa, Instituto Nacional de Câncer, Rua André Cavalcanti, 37, CEP 20231-050 Rio de Janeiro, Brazil
    • ,
  • Têmis Maria Félix

      Affiliations

    • Serviço de Genética Médica, Hospital de Clínicas de Porto Alegre, Rio Grande do Sul, Brazil
    • ,
  • Sandra L. Segal

      Affiliations

    • Serviço de Genética Médica, Hospital de Clínicas de Porto Alegre, Rio Grande do Sul, Brazil
    • ,
  • Roberto Giugliani

      Affiliations

    • Serviço de Genética Médica, Hospital de Clínicas de Porto Alegre, Rio Grande do Sul, Brazil
    • ,
  • Maria Tereza Cartaxo Muniz

      Affiliations

    • Divisão de Biologia Molecular do Departamento de Biologia do ICB-UPE, Recife, Pernambuco, Brazil
    • ,
  • Maria S. Pombo-de-Oliveira

      Affiliations

    • Divisão de Medicina Experimental, Centro de Pesquisa, Instituto Nacional de Câncer, Rua André Cavalcanti, 37, CEP 20231-050 Rio de Janeiro, Brazil
    • Corresponding Author InformationCorresponding author. Tel.: +55 21 32331324; fax: +55 21 32331470.

Received 30 May 2005

References 

  1. Wiemels JL, Smith RN, Taylor GM, Eden OB, Alexander FE, Greaves MF. Methylenetetrahydrofolate reductase (MTHFR) polymorphisms and risk of molecularly defined subtypes of childhood acute leukemia. Proc Natl Acad Sci USA. 2001;98:4004–4009
  2. Blount BC, Mack MM, Wehr CM, MacGregor JT, Hiatt RA, Wang G, et al. Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage. Proc Natl Acad Sci USA. 1997;94:3290–3295
  3. Krajinovic M, Lamothe S, Labuda D, Lemieux-Blanchard E, Theoret Y, Moghrabi A, et al. Role of MTHFR genetic polymorphisms in the susceptibility to childhood acute lymphoblastic leukemia. Blood. 2004;103:252–257
  4. Thompson JR, Gerald PF, Willoughby ML, Armstrong BK. Maternal folate supplementation in pregnancy and protection against acute lymphoblastic leukaemia in childhood: a case–control study. Lancet. 2001;358:1935–1940
  5. Franco RF, Simoes BP, Tone LG, Gabellini SM, Zago MA, Falcao RP. The methylenetetrahydrofolate reductase C677T gene polymorphism decreases the risk of childhood acute lymphocytic leukaemia. Br J Haematol. 2001;115:616–618
  6. Chor D, Faerstein E, Kaplan GA, Lynch JW, Lopes CS. Association of weight change with ethnicity and life course socioeconomic position among Brazilian civil servants. Int J Epidemiol. 2004;33:100–106

PII: S0145-2126(05)00316-4

doi: 10.1016/j.leukres.2005.08.008

Leukemia Research
Volume 30, Issue 4 , Pages 477-481 , April 2006

Article Tools