Leukemia Research
Volume 30, Issue 4 , Pages 365-372, April 2006

Chemokine receptor expression and function in childhood acute lymphoblastic leukemia of B-lineage

  • Anna Corcione

      Affiliations

    • Laboratory of Oncology, G. Gaslini Institute, Largo G. Gaslini 5, 16148 Genova, Italy
    • Corresponding Author InformationCorresponding author. Tel.: +39 010 5636342; fax: +39 010 3779820.
    • ,
  • Nicoletta Arduino

      Affiliations

    • Laboratory of Phagocyte Physiopathology and Inflammation, Department of Internal Medicine, University of Genova, Genova, Italy
    • ,
  • Elisa Ferretti

      Affiliations

    • Laboratory of Oncology, G. Gaslini Institute, Largo G. Gaslini 5, 16148 Genova, Italy
    • ,
  • Angela Pistorio

      Affiliations

    • Clinical Epidemiology and Biometry Unit, Scientific Direction, G. Gaslini Institute, Genova, Italy
    • ,
  • Monica Spinelli

      Affiliations

    • Division of Hematology Oncology, Department of Pediatrics, University of Padova, Padova, Italy
    • ,
  • Luciano Ottonello

      Affiliations

    • Laboratory of Phagocyte Physiopathology and Inflammation, Department of Internal Medicine, University of Genova, Genova, Italy
    • ,
  • Franco Dallegri

      Affiliations

    • Laboratory of Phagocyte Physiopathology and Inflammation, Department of Internal Medicine, University of Genova, Genova, Italy
    • ,
  • Giuseppe Basso

      Affiliations

    • Division of Hematology Oncology, Department of Pediatrics, University of Padova, Padova, Italy
    • ,
  • Vito Pistoia

      Affiliations

    • Laboratory of Oncology, G. Gaslini Institute, Largo G. Gaslini 5, 16148 Genova, Italy

Received 27 June 2005 published online 07 March 2011.

Abstract 

Scanty information is available on chemokine receptor expression and function in childhood B-lineage acute lymphoblastic leukemia (ALL). Thirteen pro-B, 17 early pre-B, 12 pre-B, and 9 B-ALL/Burkitt lymphoma (BL) pediatric cases were tested for CXCR1 to CXCR5 and CCR1 to CCR7 expression. CXCR2, CXCR3, and CXCR4 were expressed in the majority of cases, while the other receptors were variably expressed or absent. CXCR4 mediated chemotaxis of all leukemic cell subtypes. Freshly isolated CCR7+ early pre-B-ALL cells migrated to CCL19, whereas CCR7+ pro-B- and pre-B-ALL cells were attracted by CCL19 only following culture with soluble recombinant CD40 ligand.

Keywords: B-lineage acute lymphoblastic leukemia, Chemokines, Chemokine receptors, Chemotaxis

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PII: S0145-2126(05)00292-4

doi:10.1016/j.leukres.2005.07.009

Leukemia Research
Volume 30, Issue 4 , Pages 365-372, April 2006

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