Leukemia Research
Volume 30, Issue 2 , Pages 211-221 , February 2006

IgH and TCRγ gene rearrangements, cyclin A1 and HOXA9 gene expression in biphenotypic acute leukemias

  • M. Golemović

      Affiliations

    • Division of Immunology, Clinical Institute of Laboratory Diagnosis, Zagreb University School of Medicine, Zagreb Clinical Hospital Center, 10000 Zagreb, Croatia
    • Tel.: +385 1 2388 336; fax: +385 1 2312 079.
    • ,
  • M. Sučić

      Affiliations

    • Division of Immunology, Clinical Institute of Laboratory Diagnosis, Zagreb University School of Medicine, Zagreb Clinical Hospital Center, 10000 Zagreb, Croatia
    • ,
  • R. Zadro

      Affiliations

    • Division of Immunology, Clinical Institute of Laboratory Diagnosis, Zagreb University School of Medicine, Zagreb Clinical Hospital Center, 10000 Zagreb, Croatia
    • ,
  • S. Mrsić

      Affiliations

    • Division of Immunology, Clinical Institute of Laboratory Diagnosis, Zagreb University School of Medicine, Zagreb Clinical Hospital Center, 10000 Zagreb, Croatia
    • ,
  • M. Mikulić

      Affiliations

    • Department of Hematology, Zagreb University School of Medicine and Clinical Hospital Center, 10000 Zagreb, Croatia
    • ,
  • B. Labar

      Affiliations

    • Department of Hematology, Zagreb University School of Medicine and Clinical Hospital Center, 10000 Zagreb, Croatia
    • ,
  • L.j. Rajić

      Affiliations

    • Department of Pediatrics–Salata, Zagreb University School of Medicine and Clinical Hospital Center, 10000 Zagreb, Croatia
    • ,
  • D. Batinić

      Affiliations

    • Division of Immunology, Clinical Institute of Laboratory Diagnosis, Zagreb University School of Medicine, Zagreb Clinical Hospital Center, 10000 Zagreb, Croatia
    • Corresponding Author InformationCorresponding author.

Received 5 April 2005 ,Revised 6 July 2005 ,Accepted 6 July 2005.

References 

  1. Catovsky D, Matutes E, Buccheri V, Shetty V, Hanslip J, Yoshida N, et al. A classification of acute leukemia for the. Ann Hematol. 1991;62:16–21
  2. Bene MC, Castoldi G, Knapp W, Ludwig WD, Matutes E, Orfao A, et al. Proposals for the immunological classification of acute leukemias. European Group for the Immunological Characterisation of Leukemias (EGIL). Leukemia. 1995;9:1783–1786
  3. Rubio MT, Dhedin N, Boucheix C, Bourhis JH, Reman O, Boiron JM, et al. Adult T-biphenotypic acute leukemia: clinical and biological features and outcome. Br J Haematol. 2003;123:842–849
  4. Lau LG, Tan LK, Koay ESC , Ee MHL , Tan SH, Liu TC. Acute lymphoblastic leukemia with the phenotype of a putative B-cell/T-cell bipotential precursor. Am J Hematol. 2004;77:156–160
  5. Matutes E, Morilla R, Farahat N, Carbonell F, Swansbury J, Dyer M, et al. Definition of acute biphenotypic leukemia. Hematologica. 1997;82:64–66
  6. Orfao A, Ortuño F, de Santiago M, Lopez A, San Miguel J. Immunophenotyping of acute leukemias and myelodysplastic syndromes. Cytometry. 2004;58A:62–71
  7. Killick S, Matutes E, Powles RL, Hamblin M, Swansbury J, Treleaven JG, et al. Outcome of biphenotypic acute leukemia. Haematologica. 1999;84:699–706
  8. Legrand O, Perrot JY, Simonin G, Baudard M, Cadiou M, Blanc C, et al. Adult biphenotypic acute leukemia: an entity with poor prognosis which is related to unfavourable cytogenetics and P-glycoprotein over-expression. Br J Haematol. 1998;100:147–155
  9. Wuchtier C, Ratei R, Spahn G, Schoch C, Harbott J, Schnittger S, et al. Impact of CD133 (AC133) and CD90 expression analysis for acute leukemia immunophenotyping. Haematologica. 2001;86:154–161
  10. Carbonell F, Swansbury J, Min T, Matutes E, Farahat N, Buccheri V, et al. Cytogenetic findings in acute biphenotypic leukemia. Leukemia. 1996;10:1283–1287
  11. European Group for the Immunological Classification of Leukaemias. The value of c-kit in the diagnosis of biphenotypic acute leukemia. Leukaemia. 1998;12:2038
  12. Batinic D. Imunoloska fenotipizacija akutnih leukemija djecje dobi. Pediatr Croat. 1997;78:83–87
  13. Rothe G, Schmitz G for the Working Group on Flow Cytometry and Image Analysis. Consensus protocol for the flow cytometric immunophenotyping of haematopoietic malignancies. Leukemia. 1996;10:877–895
  14. Yamada M, Hudson S, Tournay O, Bittenbender S, Shane SS, Lange B, et al. Detection of minimal disease in hematopoietic malignancies of the B-cell lineage by using third-complementary-determining region (CDR-III)-specific probes. Proc Natl Acad Sci. 1989;86:5123–5127
  15. Salo A, Pakkala S, Jansson SE, Helminen P, Palotie A. Monitoring of adult B-cell lineage acute lymphoblastic leukemia: validation of a simple method for detecting immunoglobulin heavy chain gene clonality. Blood. 1993;7:1459–1465
  16. Födinger M, Buchmayer H, Schwarzinger I, Simonitsch I, Winkler K, Jäger U, et al. Multiplex PCR for rapid detection of T-cell receptor-gamma chain gene rearrangements in patients with lymphoproliferative diseases. Br J Haematol. 1996;94:136–139
  17. Trainor KJ, Brisco MJ, Wan JH, Neoh S, Grist S, Morley AA. Gene rearrangement in B- and T-lymphoproliferative disease detected by the polymerase chain reaction. Blood. 1991;78:192–196
  18. Oostveen JW, Bijl J, Kreike M, Rieger E, van der Raaij-Helmer LMH, Walboomers JMM, et al. Expression of HOX C4, HOX C5 and HOX C6in human lymphoid cell lines, leukemias and benign and malignant lymphoid tissue. Blood. 1996;87:1737–1745
  19. Krämer A, Hochhaus A, Saußele S, Reichert A, Willer A, Hehlmann R. Cyclin A1 is predominantly expressed in hematological malignancies with myeloid differentiation. Leukemia. 1998;12:893–898
  20. Kawagoe H, Humphries RK, Blair A, Sutherland HJ, Hogge DE. Expression of HOX genes, HOX cofactors and MLL in phenotypically and functionally defined subpopulations of leukemic and normal human hematopoietic cells. Leukemia. 1999;13:687–698
  21. Yang R, Nakamaki T, Lübbert M, Said J, Sakashita A, Freyaldenhoven BS, et al. Cyclin A1 expression in leukemia and normal hematopoietic cells. Blood. 1999;93:2067–2074
  22. Golub TR, Slonim DK, Tamayo P, Huard C, Gaasenbeek M, Mesirov JP, et al. Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. Science. 1999;286:531–537
  23. Buske C, Feurling-Buske M, Antonchuk J, Rosten P, Hogge DE, Eaves CJ, et al. Overexpression of HOXA10perturbs human lymphomyelopoiesis in vitro and in vivo. Blood. 2001;97:2286–2292
  24. Buccheri V, Matutes E, Dyer MJ, Catovsky D. Lineage commitment in biphenotypic acute leukemia. Leukemia. 1993;7:919–927
  25. Thorsteindottir U, Mamo A, Kroon E, Jerome L, Bijl J, Lawrence HJ, et al. Overexpression of the myeloid leukemia-associated Hoxa9 gene in bone marrow cells induces stem cell expansion. Blood. 2002;99:121–129
  26. Lawrence HJ, Helgason CD, Sauvageau G, Fong S, Izon DJ, Humphries RK, et al. Mice bearing a targeted interruption of the homeobox gene HOXA9 have defects in myeloid, erythroid, and lymphoid hematopoiesis. Blood. 1997;89:1922–1930
  27. Casas S, Nagy B, Elonen E, Aventin A, Larramendy ML, Sierra J, et al. Aberrant expression of HOXA9, DEK, CBL and CSF1R in acute myeloid leukemia. Leuk Lymphoma. 2003;44:1935–1941
  28. Bertrand FE, Spengeman DJ, Shah N, LeBien TW. B-cell development in the presence of the MLL/AF4 oncoprotein proceeds in the absence of HOXA7 and HOXA9 expression. Leukemia. 2003;17:2454–2459
  29. Ernst P, Mabon M, Davidson AJ, Zon LI, Korsmeyer SJ. An Mll-dependent Hox program drives hematopoietic progenitor expansion. Curr Biol. 2004;14:2063–2069
  30. Müller C, Yang R, Park DJ, Serve H, Berdel WE, Koeffler HP. The aberrant fusion proteins PML-RARα and PLZF-RARα contribute to the overexpression of cyclin A1 in acute promyleocytic leukemia. Blood. 2000;96:3894–3899
  31. Liao C, Wang XY, Wei HQ, Li SQ, Merghoub T, Pandolfi PP, et al. Altered myelopoiesis and the development of acute myeloid leukemia in transgenic mice overexpressing cyclin A1. Proc Natl Acad Sci. 2001;98:6853–6858
  32. Müller C, Yang R, Idos G, Tidow N, Diederichs S, Koch OM, et al. C-myb transactivates the human cyclin A1 promoter and induces cyclin A1 gene expression. Blood. 1999;94:4255–4262
  33. Smith MA, Luxton RW, Pallister CJ, Smith GJ. A novel predictive model of outcome in de novo AML based on S-phase activity and proliferative response of blast cells to haemopoietic growth factors. Leuk Res. 2002;26:345–348
  34. Smith MA, Smith JG, Pallister , Singer CRJ. Kinetic characteristics of de novo and secondary AML cells influence their response to haemopoietic growth factor (HGF) priming and correlate with clinical outcome. Leuk Res. 1999;23:987–994
  35. Löwenberg B, van Putten WLJ, Touw IP, Delwel R, Santini V. Autonomous proliferation of leukemic cells in vitro as a determinant of prognosis in adult acute myeloid leukemia. N Engl J Med. 1993;328:614–619

PII: S0145-2126(05)00278-X

doi: 10.1016/j.leukres.2005.07.001

Leukemia Research
Volume 30, Issue 2 , Pages 211-221 , February 2006

Article Tools

* Image Usage & Resolution