Leukemia Research
Volume 30, Issue 2 , Pages 164-169 , February 2006

Opposing effects of aspirin and acetaminophen use on risk of adult acute leukemia

  • Joli R. Weiss

      Affiliations

    • Department of Epidemiology, A-316 Carlton House, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    • ,
  • Julie A. Baker

      Affiliations

    • Department of Epidemiology, A-316 Carlton House, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    • ,
  • Maria R. Baer

      Affiliations

    • Department of Medicine, Leukemia Section, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    • ,
  • Ravi J. Menezes

      Affiliations

    • Department of Epidemiology, A-316 Carlton House, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    • ,
  • Susan Nowell

      Affiliations

    • Department of Epidemiology, A-316 Carlton House, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    • ,
  • Kirsten B. Moysich

      Affiliations

    • Department of Epidemiology, A-316 Carlton House, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 716 845 8004; fax: +1 716 845 1126.

Received 10 May 2005 ,Revised 29 June 2005 ,Accepted 30 June 2005.

References 

  1. Hoelzer D, Gokbuget N. In:  Henderson E,  Lister T,  Greaves M editor. Acute lymphoblastic leukemia in adults in leukemia. 7th ed.. Philadelphia: Saunders; 2002;
  2. Horwitz M. In:  Wiernik PH editors. Epidemiology and genetics of acute and chronic leukemia in American Cancer Society Atlas of Clinical Oncology: adult leukemias. Hamilton: BC Decker, Inc.; 2001;
  3. Collet JP, Sharpe C, Belzile E, et al. Colorectal cancer prevention by non-steroidal anti-inflammatory drugs: effects of dosage and timing. Br J Cancer. 1999;81(1):62–68
  4. Rosenberg L, Louik C, Shapiro S. Nonsteroidal antiinflammatory drug use and reduced risk of large bowel carcinoma. Cancer. 1998;82(12):2326–2333
  5. Thun MJ. Aspirin and gastrointestinal cancer. Adv Exp Med Biol. 1997;400A:395–402
  6. Marnett LJ. Aspirin and related nonsteroidal anti-inflammatory drugs as chemopreventive agents against colon cancer. Prev Med. 1995;24(2):103–106
  7. Farrow DC, Vaughan TL, Hansten PD, et al. Use of aspirin and other nonsteroidal anti-inflammatory drugs and risk of esophageal and gastric cancer. Cancer Epidemiol Biomarkers Prev. 1998;7(2):97–102
  8. Funkhouser EM, Sharp GB. Aspirin and reduced risk of esophageal carcinoma. Cancer. 1995;76(7):1116–1119
  9. Zaridze D, Borisova E, Maximovitch D, Chkhikvadze V. Aspirin protects against gastric cancer: results of a case–control study from Moscow, Russia. Int J Cancer. 1999;82(4):473–476
  10. Moysich KB, Mettlin C, Piver MS, et al. Regular use of analgesic drugs and ovarian cancer risk. Cancer Epidemiol Biomarkers Prev. 2001;10(8):903–906
  11. Rosenberg L, Palmer JR, Rao RS, et al. A case–control study of analgesic use and ovarian cancer. Cancer Epidemiol Biomarkers Prev. 2000;9(9):933–937
  12. Akhmedkhanov A, Toniolo P, Zeleniuch-Jacquotte A, et al. Aspirin and epithelial ovarian cancer. Prev Med. 2001;33(6):682–687
  13. Schreinemachers DM, Everson RB. Aspirin use and lung, colon, and breast cancer incidence in a prospective study. Epidemiology. 1994;5(2):138–146
  14. Coogan PF, Rao SR, Rosenberg L, et al. The relationship of nonsteroidal anti-inflammatory drug use to the risk of breast cancer. Prev Med. 1999;29(2):72–76
  15. Harris RE, Namboodiri KK, Farrar WB. Nonsteroidal antiinflammatory drugs and breast cancer. Epidemiology. 1996;7(2):203–205
  16. Subongkot S, Frame D, Leslie W, Drajer D. Selective cyclooxygenase-2 inhibition: a target in cancer prevention and treatment. Pharmacotherapy. 2003;23(1):9–28
  17. Thun MJ, Henley SJ, Patrono C. Nonsteroidal anti-inflammatory drugs as anticancer agents: mechanistic, pharmacologic, and clinical issues. J Natl Cancer Inst. 2002;94(4):252–266
  18. Gupta RA, DuBois RN. Aspirin, NSAIDS, and colon cancer prevention: mechanisms?. Gastroenterology. 1998;114(5):1095–1098
  19. Shiff SJ, Rigas B. The role of cyclooxygenase inhibition in the antineoplastic effects of nonsteroidal antiinflammatory drugs (NSAIDs). J Exp Med. 1999;190(4):445–450
  20. Roberts II LJ, Morrow JD. Analgesic-antipyretic and antiinflammatory agents and drugs employed in the treatment of gout. In:  Hardman JG,  Limbird LE editor. The pharmacological basis of therapeutics. New York: McGraw-Hill; 2001;
  21. Kasum CM, Blair CK, Folsom AR, Ross JA. Non-steroidal anti-inflammatory drug use and risk of adult leukemia. Cancer Epidemiol Biomarkers Prev. 2003;12(6):534–537
  22. Traversa G, Menniti-Ippolito F, Da Cas R, et al. Drug use and acute leukemia. Pharmacoepidemiol Drug Saf. 1998;7(2):113–123
  23. Bennett JM, Catovsky D, Daniel MT, et al. Proposed revised criteria for the classification of acute myeloid leukemia. A report of the French–American–British Cooperative Group. Ann Intern Med. 1985;103(4):620–625
  24. Bennett JM, Catovsky D, Daniel MT, et al. The morphological classification of acute lymphoblastic leukaemia: concordance among observers and clinical correlations. Br J Haematol. 1981;47(4):553–561
  25. Klampfer L, Cammenga J, Wisniewski HG, Nimer SD. Sodium salicylate activates caspases and induces apoptosis of myeloid leukemia cell lines. Blood. 1999;93(7):2386–2394
  26. Kopp E, Ghosh S. Inhibition of NF-kappa B by sodium salicylate and aspirin. Science. 1994;265(5174):956–959
  27. Yin MJ, Yamamoto Y, Gaynor RB. The anti-inflammatory agents aspirin and salicylate inhibit the activity of I(kappa)B kinase-beta. Nature. 1998;396(6706):77–80
  28. Baldwin AS. Series introduction: the transcription factor NF-kappaB and human disease. J Clin Invest. 2001;107(1):3–6
  29. Baumgartner B, Weber M, Quirling M, et al. Increased IkappaB kinase activity is associated with activated NF-kappaB in acute myeloid blasts. Leukemia. 2002;16(10):2062–2071
  30. Guzman ML, Neering SJ, Upchurch D, et al. Nuclear factor-kappaB is constitutively activated in primitive human acute myelogenous leukemia cells. Blood. 2001;98(8):2301–2307
  31. Rannug U, Holme JA, Hongslo JK, et al. International commission for protection against environmental mutagens and carcinogens. An evaluation of the genetic toxicity of paracetamol. Mutat Res. 1995;327(1–2):179–200
  32. IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Paracetamol (acetaminophen). IARC Monogr Eval Carcinog Risks Hum. 1990;50:307–332
  33. Cramer DW, Harlow BL, Titus-Ernstoff L, et al. Over-the-counter analgesics and risk of ovarian cancer. Lancet. 1998;351(9096):104–107
  34. McLaughlin JK, Blot WJ, Mehl ES, Fraumeni JF. Relation of analgesic use to renal cancer: population-based findings. Natl Cancer Inst Monogr. 1985;69:217–222
  35. Friis S, Nielsen GL, Mellemkjaer L, et al. Cancer risk in persons receiving prescriptions for paracetamol: a Danish cohort study. Int J Cancer. 2002;97(1):96–101
  36. Piper JM, Tonascia J, Matanoski GM. Heavy phenacetin use and bladder cancer in women aged 20 to 49 years. N Engl J Med. 1985;313(5):292–295
  37. Derby LE, Jick H. Acetaminophen and renal and bladder cancer. Epidemiology. 1996;7(4):358–362
  38. Gago-Dominguez M, Yuan JM, Castelao JE, Ross RK, Yu MC. Regular use of analgesics is a risk factor for renal cell carcinoma. Br J Cancer. 1999;81(3):542–548
  39. Kaye JA, Myers MW, Jick H. Acetaminophen and the risk of renal and bladder cancer in the general practice research database. Epidemiology. 2001;12(6):690–694
  40. Baker JA, Weiss JR, Czuczman MS, et al. Regular use of aspirin or acetaminophen and risk of non-Hodgkin lymphoma. Cancer Causes Control. 2005;16:301–308
  41. Chang ET, Zheng T, Weir EG, et al. Aspirin and the risk of Hodgkin's lymphoma in a population-based case–control study. J Natl Cancer Inst. 2004;96(4):305–315
  42. Cornelison TL, Natarajan N, Piver MS, Mettlin CJ. Tubal ligation and the risk of ovarian carcinoma. Cancer Detect Prev. 1997;21(1):1–6
  43. Suh O, Mettlin C, Petrelli NJ. Aspirin use, cancer, and polyps of the large bowel. Cancer. 1993;72(4):1171–1177
  44. Mettlin C, Croghan I, Natarajan N, Lane W. The association of age and familial risk in a case–control study of breast cancer. Am J Epidemiol. 1990;131(6):973–983
  45. Mettlin C, Natarajan N, Huben R. Vasectomy and prostate cancer risk. Am J Epidemiol. 1990;132(6):1056–1061[discussion 1062–5]
  46. Mettlin C. Milk drinking, other beverage habits, and lung cancer risk. Int J Cancer. 1989;43(4):608–612

PII: S0145-2126(05)00274-2

doi: 10.1016/j.leukres.2005.06.023

Leukemia Research
Volume 30, Issue 2 , Pages 164-169 , February 2006

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