Leukemia Research
Volume 30, Issue 2 , Pages 183-189 , February 2006

Transferrin receptor-1 and 2 expression in chronic lymphocytic leukemia

  • Tatjana Smilevska

      Affiliations

    • Laboratory of Molecular Genetics and Cytogenetics, University of Thessaly, Larissa, Greece
    • Hematology Department and HCT Unit, G. Papanicolaou Hospital, Thessaloniki, Greece
    • ,
  • Kostas Stamatopoulos

      Affiliations

    • Hematology Department and HCT Unit, G. Papanicolaou Hospital, Thessaloniki, Greece
    • Corresponding Author InformationCorresponding author. Tel.: +30 2310 350538; fax: +30 2310 350521.
    • ,
  • Maria Samara

      Affiliations

    • Laboratory of Molecular Genetics and Cytogenetics, University of Thessaly, Larissa, Greece
    • ,
  • Chrysoula Belessi

      Affiliations

    • Hematology Department, Nikea General Hospital, Piraeus, Greece
    • ,
  • Aliki Tsompanakou

      Affiliations

    • Hematology Department and HCT Unit, G. Papanicolaou Hospital, Thessaloniki, Greece
    • ,
  • George Paterakis

      Affiliations

    • Immunology Laboratory, G. Gennimatas Hospital, Athens, Greece
    • ,
  • Niki Stavroyianni

      Affiliations

    • Hematology Department and HCT Unit, G. Papanicolaou Hospital, Thessaloniki, Greece
    • ,
  • Ioanna Athanasiadou

      Affiliations

    • Hematology Department and HCT Unit, G. Papanicolaou Hospital, Thessaloniki, Greece
    • ,
  • Ioanna Chiotoglou

      Affiliations

    • Laboratory of Molecular Genetics and Cytogenetics, University of Thessaly, Larissa, Greece
    • ,
  • Anastasia Hadzidimitriou

      Affiliations

    • Hematology Department and HCT Unit, G. Papanicolaou Hospital, Thessaloniki, Greece
    • ,
  • Anastasia Athanasiadou

      Affiliations

    • Hematology Department and HCT Unit, G. Papanicolaou Hospital, Thessaloniki, Greece
    • ,
  • Vassiliki Douka

      Affiliations

    • Hematology Department and HCT Unit, G. Papanicolaou Hospital, Thessaloniki, Greece
    • ,
  • Riad Saloum

      Affiliations

    • Hematology Department and HCT Unit, G. Papanicolaou Hospital, Thessaloniki, Greece
    • ,
  • Nikolaos Laoutaris

      Affiliations

    • Hematology Department, Nikea General Hospital, Piraeus, Greece
    • ,
  • Achilles Anagnostopoulos

      Affiliations

    • Hematology Department and HCT Unit, G. Papanicolaou Hospital, Thessaloniki, Greece
    • ,
  • Athanasios Fassas

      Affiliations

    • Hematology Department and HCT Unit, G. Papanicolaou Hospital, Thessaloniki, Greece
    • ,
  • Nikolaos Stathakis

      Affiliations

    • Department of Medicine, University of Thessaly, Larissa, Greece
    • ,
  • Panagoula Kollia

      Affiliations

    • Laboratory of Molecular Genetics and Cytogenetics, University of Thessaly, Larissa, Greece
    • Department of Biology, University of Thessaly, Larissa, Greece

Received 1 December 2004 ,Accepted 15 June 2005.

References 

  1. Richardson DR, Ponka P. The molecular mechanisms of the metabolism and transport of iron in normal and neoplastic cells. Biochim Biophys Acta. 1997;1331:1–40
  2. Richardson DR. Mysteries of the transferring-transferrin receptor 1 interaction uncovered. Cell. 2004;116:483–485
  3. Lieu PT, Heiskala M, Peterson PA, Yang Y. The roles of iron in health and disease. Mol Aspects Med. 2001;22:1–87
  4. Brissot P, Troadec MB, Loreal O. The clinical relevance of new insights in iron transport and metabolism. Curr Hematol Rep. 2004;3:107–115
  5. Kuhn LC. Molecular regulation of iron proteins. Baillieres Clin Haematol. 1994;7:763–785
  6. Kawabata H, Yang R, Hirama T, Vuong PT, Kawano S, Gombart AF, et al. Molecular cloning of transferrin receptor 2. A new member of the transferrin receptor-like family. J Biol Chem. 1999;274:20826–20832
  7. Kawabata H, Nakamaki T, Ikonomi P, Smith RD, Germain RS, Koeffler HP. Expression of transferrin receptor 2 in normal and neoplastic hematopoietic cells. Blood. 2001;98:2714–2719
  8. Kollia P, Samara M, Stamatopoulos K, Belessi C, Stavroyianni N, Tsompanakou A, et al. Molecular evidence for transferrin receptor 2 expression in all FAB subtypes of acute myeloid leukemia. Leuk Res. 2003;27:1101–1103
  9. Damle RN, Ghiotto F, Valetto A, Albesiano E, Fais F, Yan XJ, et al. B-cell chronic lymphocytic leukemia cells express a surface membrane phenotype of activated, antigen-experienced B lymphocytes. Blood. 2002;99:4087–4093
  10. Arva E, Andersson B. Kinetics of cytokine release and expression of lymphocyte cell-surface activation markers after in vitro stimulation of human peripheral blood mononuclear cells with Streptococcus pneumoniae. Scand J Immunol. 1999;49:237–243
  11. Kishimoto TK, Jutila MA, Butcher EC. Identification of a human peripheral lymph node homing receptor: a rapidly down-regulated adhesion molecule. Proc Natl Acad Sci USA. 1990;87:2244–2248
  12. Simms PE, Ellis TM. Utility of flow cytometric detection of CD69 expression as a rapid method for determining poly- and oligoclonal lymphocyte activation. Clin Diagn Lab Immunol. 1996;3:301–304
  13. Cheson BD, Bennett JM, Grever M, Kay N, Keating MJ, O’Brien S, et al. National Cancer Institute-sponsored Working Group guidelines for chronic lymphocytic leukemia: revised guidelines for diagnosis and treatment. Blood. 1996;87:4990–4997
  14. Stavroyianni N, Belessi C, Stamatopoulos K, Kosmas C, Paterakis G, Abazis D, et al. Expression of recombination activating genes-1 and 2 immunoglobulin heavy chain gene rearrangements in acute myeloid leukemia: evaluation of biological and clinical significance in a series of 76 uniformly treated patients and review of the literature. Haematologica. 2003;88:268–274
  15. Kollia P, Stavroyianni N, Stamatopoulos K, Zoi K, Viniou N, Mantzourani M, et al. Molecular analysis of transferrin receptor mRNA expression in acute myeloid leukaemia. Br J Haematol. 2001;115:19–24
  16. Marks J, Hoogenboom H, Bonnert T, McCafferty J, Griffiths A, Winter G. By-passing immunization: human antibodies from V-gene libraries displayed on phage. J Mol Biol. 1991;222:581–597
  17. Lefranc M.-P. IMGT databases, web resources and tools for immunoglobulin and T cell receptor sequence analysis, http://imgt.cines.fr. Leukemia 2003, 17, 260–66.
  18. Lefranc M-P, Lefranc G. The immunoglobulin factsbook. London: Academic Press; 2001;
  19. Giudicelli V, Chaume D, Lefranc M-P. IMGT/V-QUEST, an integrated software program for immunoglobulin and T cell receptor V-J and V-D-J rearrangement analysis. Nucleic Acids Res. 2004;32:W435–W440
  20. Seligman PA, Kovar J, Schleicher RB, Gelfand EW. Transferrin-independent iron uptake supports B lymphocyte growth. Blood. 1991;78:1526–1531
  21. Ned RM, Swat W, Andrews NC. Transferrin receptor 1 is differentially required in lymphocyte development. Blood. 2003;102:3711–3718
  22. Chiorazzi N, Ferrarini M. B cell chronic lymphocytic leukemia: lessons learned from studies of the B cell antigen receptor. Annu Rev Immunol. 2003;21:841–894
  23. Stevenson FK, Caligaris-Cappio F. Chronic lymphocytic leukemia: revelations from the B-cell receptor. Blood. 2004;103:4389–4395
  24. Dighiero G. Perspectives in chronic lymphocytic leukemia biology and management. Hematol Oncol Clin North Am. 2004;18:927–943
  25. Papavasiliou FN, Schatz DG. Somatic hypermutation of immunoglobulin genes: merging mechanisms for genetic diversity. Cell. 2002;109(Suppl.):S35–S44
  26. Gurrieri C, McGuire P, Zan H, Yan XJ, Cerutti A, Albesiano E, et al. Chronic lymphocytic leukemia B cells can undergo somatic hypermutation and intraclonal immunoglobulin V(H)DJ(H) gene diversification. J Exp Med. 2002;196:629–639
  27. D’Arena G, Musto P, Nunziata G, Cascavilla N, Savino L, Pistolese G. CD69 expression in B-cell chronic lymphocytic leukemia: a new prognostic marker?. Haematologica. 2001;86:995–996
  28. Subramaniam VN, Summerville L, Wallace DF. Molecular and cellular characterization of transferrin receptor 2. Cell Biochem Biophys. 2002;36:235–239
  29. Trinder D, Baker E. Transferrin receptor 2: a new molecule in iron metabolism. Int J Biochem Cell Biol. 2003;35:292–296

PII: S0145-2126(05)00223-7

doi: 10.1016/j.leukres.2005.06.006

Leukemia Research
Volume 30, Issue 2 , Pages 183-189 , February 2006

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