Transferrin receptor-1 and 2 expression in chronic lymphocytic leukemia

Smilevska, Tatjana; Stamatopoulos, Kostas; Samara, Maria; Belessi, Chrysoula; Tsompanakou, Aliki; Paterakis, George; Stavroyianni, Niki; Athanasiadou, Ioanna; Chiotoglou, Ioanna; Hadzidimitriou, Anastasia; Athanasiadou, Anastasia; Douka, Vassiliki; Saloum, Riad; Laoutaris, Nikolaos; Anagnostopoulos, Achilles; Fassas, Athanasios; Stathakis, Nikolaos; Kollia, Panagoula

doi:10.1016/j.leukres.2005.06.006

« Previous Next »Leukemia Research
Volume 30, Issue 2 , Pages 183-189, February 2006

Transferrin receptor-1 and 2 expression in chronic lymphocytic leukemia

Tatjana Smilevska
- Laboratory of Molecular Genetics and Cytogenetics, University of Thessaly, Larissa, Greece
- Hematology Department and HCT Unit, G. Papanicolaou Hospital, Thessaloniki, Greece
Kostas Stamatopoulos
- Hematology Department and HCT Unit, G. Papanicolaou Hospital, Thessaloniki, Greece
- Corresponding author. Tel.: +30 2310 350538; fax: +30 2310 350521.
Maria Samara
- Laboratory of Molecular Genetics and Cytogenetics, University of Thessaly, Larissa, Greece
Chrysoula Belessi
- Hematology Department, Nikea General Hospital, Piraeus, Greece
Aliki Tsompanakou
- Hematology Department and HCT Unit, G. Papanicolaou Hospital, Thessaloniki, Greece
George Paterakis
- Immunology Laboratory, G. Gennimatas Hospital, Athens, Greece
Niki Stavroyianni
- Hematology Department and HCT Unit, G. Papanicolaou Hospital, Thessaloniki, Greece
Ioanna Athanasiadou
- Hematology Department and HCT Unit, G. Papanicolaou Hospital, Thessaloniki, Greece
Ioanna Chiotoglou
- Laboratory of Molecular Genetics and Cytogenetics, University of Thessaly, Larissa, Greece
Anastasia Hadzidimitriou
- Hematology Department and HCT Unit, G. Papanicolaou Hospital, Thessaloniki, Greece
Anastasia Athanasiadou
- Hematology Department and HCT Unit, G. Papanicolaou Hospital, Thessaloniki, Greece
Vassiliki Douka
- Hematology Department and HCT Unit, G. Papanicolaou Hospital, Thessaloniki, Greece
Riad Saloum
- Hematology Department and HCT Unit, G. Papanicolaou Hospital, Thessaloniki, Greece
Nikolaos Laoutaris
- Hematology Department, Nikea General Hospital, Piraeus, Greece
Achilles Anagnostopoulos
- Hematology Department and HCT Unit, G. Papanicolaou Hospital, Thessaloniki, Greece
Athanasios Fassas
- Hematology Department and HCT Unit, G. Papanicolaou Hospital, Thessaloniki, Greece
Nikolaos Stathakis
- Department of Medicine, University of Thessaly, Larissa, Greece
Panagoula Kollia
- Laboratory of Molecular Genetics and Cytogenetics, University of Thessaly, Larissa, Greece
- Department of Biology, University of Thessaly, Larissa, Greece

Received 1 December 2004; accepted 15 June 2005. published online 07 March 2011.

Abstract

Transferrin receptor (TfR)-1 and 2 mRNA and CD71 (TfR1) expression was analyzed in 118 CLL patients. Ninety-five out of 109 analyzed cases expressed CD71, mostly at a high level; 60% of CD71 (+) cases were IGH-mutated. All samples were TfR1 mRNA (+); TfR2-alpha/beta mRNA was detected in, respectively, 52/102 and 100/109 cases. Competitive RT-PCR showed widely divergent levels of TfR1 mRNA in cases with high CD71 expression, alluding to postrtanscriptional control of TfR1 expression in CLL. The almost uniformly high CD71 expression in CLL is in keeping with the activated status of neoplastic cells, regardless of IGH mutational load.

Keywords: B cells, Chronic lymphocytic leukemia, Iron, Transferrin receptor, IG genes