Leukemia Research
Volume 29, Issue 8 , Pages 955-959 , August 2005

Uptake of high density lipoprotein (HDL) cholesteryl esters by human acute leukemia cells

  • Romelia Pinheiro Gonçalves

      Affiliations

    • The Heart Institute (InCor) of the São Paulo University Medical School Hospital, Laboratório de Metabolismo de Lípides. Av. Dr. Enéas de Carvalho Aguiar, 44, 1 ss, São Paulo 05403-000, Brazil
    • ,
  • Debora Garcia Rodrigues

      Affiliations

    • The Heart Institute (InCor) of the São Paulo University Medical School Hospital, Laboratório de Metabolismo de Lípides. Av. Dr. Enéas de Carvalho Aguiar, 44, 1 ss, São Paulo 05403-000, Brazil
    • ,
  • Raul C. Maranhão

      Affiliations

    • The Heart Institute (InCor) of the São Paulo University Medical School Hospital, Laboratório de Metabolismo de Lípides. Av. Dr. Enéas de Carvalho Aguiar, 44, 1 ss, São Paulo 05403-000, Brazil
    • Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil
    • Corresponding Author InformationCorresponding author. Tel.: +55 11 3069 5108; fax: +55 11 3069 5574.

Received 18 October 2004 ,Revised 27 January 2005 ,Accepted 31 January 2005.

References 

  1. Musolino C, Clabro L, Bellomo G, Cincotta M, DiGiacomo V, Pezzano C, et al. Lipid profile in hematologic neoplasms. Recenti Prog Med. 2002;93(5):298–301
  2. Allampallam K, Dutt D, Nair C, Shetty V, Mundle S, Lisak L, et al. The clinical and biological significance of abnormal lipid profiles in patients with myelodysplastic syndromes. J Hematother Stem Cells. 2000;9(2):247–255
  3. Scribano D, Baroni S, Pagano L, Zuppi C, Leone G, Giardina B. Return to normal values of lipid pattern after effective chemotherapy in acute lymphoblastic leukemia. Haematologica. 1996;81(4):343–345
  4. Halton JM, Nazir DJ, McQueen MJ, Barr RD. Blood lipid profiles in children with acute lymphoblastic leukemia. Cancer. 1998;83(2):379–384
  5. Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DA, Gralnick HR, et al. Proposals for the classification of the myelodysplastic syndromes. Br J Haematol. 1982;51:189–199
  6. Friedewald WT, Levy RI, Fredricson DS. Estimation of the concentration of low density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972;18:499–502
  7. Havel RJ, Eder HÁ , Bradglon JH. The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. J Clin Invest. 1955;34:1345–1353
  8. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the folin phenol reagent. J Biol Chem. 1951;193:265–275
  9. Hungria VTM , Latrilha MC, Rodrigues DG, Bydlowski SP, Chiattone CS, Maranhão RC. Metabolism of a cholesterol-rich microemulsion (LDE) in patients with multiple myeloma and a preliminary clinical study of LDE as a drug vehicle for the treatment of the disease. Cancer Chemother Pharmacol. 2004;53:51–60
  10. Rudling M, Gafvels M, Parini P, Gahrton G, Angelin B. Lipoprotein receptors in acute myelogenous leukemia: failure to detect increased low-density lipoprotein (LDL) receptor numbers in cell membranes despite increased cellular LDL degradation. Am J Pathol. 1998;153(6):1923–1935
  11. Pussinen PJ, Karten B, Wintersperger A, Reicher H, McLean M, Malle E, et al. The human breast carcinoma cell line HBL-100 acquires exogenous cholesterol from high-density lipoprotein via CLA-1 (CD-36 and LIMPII analogous 1)-mediated selective cholesteryl ester uptake. Biochem J. 2000;349:559–566
  12. Wadsack C, Hirschmugl B, Hammer A, Levak-Frank S, Kosarsky KF, Sattler W, et al. Scavanger receptor class B, type I on non-malignant and malignant human epithelial cells mediates cholesteryl ester-uptake from high density lipoproteins. Int J Biochem Cell Biol. 2003;35(4):441–454
  13. Martin G, Pilon A, Albert C, Vallé M, Hum DW, Fruchart JC, et al. Comparison of expression and regulation of the high-density lipoprotein receptor SR-BI and the low-density lipoprotein receptor in human adrenocortical carcinoma NCI-H295 cells. Eur J Biochem. 1999;261:481–491
  14. Wang N, Arai T, Ji Y, Rinninger F, Tall AR. Liver-specific overexpression of scavanger receptor BI decreases levels of very low density lipoprotein apo B, low density lipoprotein apo B and high density lipoprotein in transgenic mice. J Biol Chem. 1998;273(49):32920–32926
  15. Vassiliou G, Benoist F, Lau P, Kavaslar GN, McPherson R. The low density lipoprotein receptor-related protein contributes to selective uptake of HDL-cholesteryl esters by SW872 liposarcoma cells and primary human adipocytes. J Biol Chem. 2001;276(52):48823–48830

PII: S0145-2126(05)00060-3

doi: 10.1016/j.leukres.2005.01.013

Leukemia Research
Volume 29, Issue 8 , Pages 955-959 , August 2005

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