Idiopathic hypereosinophilic syndrome: a case evolving in B-lymphoblastic lymphoma

Rapanotti, Maria Cristina; Caruso, Roberta; Bernardini, Sergio; Coletti, Valentina; Lo-Coco, Francesco; De Rossi, Giulio

doi:10.1016/j.leukres.2005.01.010

« Previous Next »Leukemia Research
Volume 29, Issue 8 , Pages 975-979, August 2005

Idiopathic hypereosinophilic syndrome: a case evolving in B-lymphoblastic lymphoma

Maria Cristina Rapanotti
- Dipartimento di Medicina Interna, Facoltà di Medicina e Chirurgia, University “Tor Vergata”, Viale Oxford 81, 00133 Rome, Italy
- Corresponding author. Tel.: +39 06 20902259; fax: +39 06 20902270.
Roberta Caruso
- Hematological Unit, Children's Hospital and Research Institute “Bambino Gesù”, Piazza S. Onofrio 4, 00165 Rome, Italy
Sergio Bernardini
- Dipartimento di Medicina Interna, Facoltà di Medicina e Chirurgia, University “Tor Vergata”, Viale Oxford 81, 00133 Rome, Italy
Valentina Coletti
- Hematological Unit, Children's Hospital and Research Institute “Bambino Gesù”, Piazza S. Onofrio 4, 00165 Rome, Italy
Francesco Lo-Coco
- Dipartimento di Biopatologia e Diagnostica per Immagini, Facoltà di Medicina e Chirurgia, University “Tor Vergata”, Via Montpellier 1, 00133 Rome, Italy
Giulio De Rossi
- Hematological Unit, Children's Hospital and Research Institute “Bambino Gesù”, Piazza S. Onofrio 4, 00165 Rome, Italy

Received 30 November 2004; received in revised form 18 January 2005; accepted 18 January 2005. published online 07 March 2011.

Abstract

Idiopathic hypereosinophilic syndrome (HES) is a rare disease characterized by tissue involvement and organ dysfunction due to abnormal eosinophil proliferation. Evolution of HES into myeloid or T-cell malignancies has been frequently reported. Here, we describe a case of HES that preceded the occurrence of a high-grade B-lymphoblastic lymphoma in which clonal evolution has been demonstrated at the molecular level.

Keywords: Idiopathic hypereosinophilic syndrome, Eosinophilic leukemia, B-cell clonality