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Leukemia Research
Volume 29, Issue 8
, Pages 893-899
, August 2005
Over-expression of Flt3 induces NF-κB pathway and increases the expression of IL-6
References
- . NF-kappa B: a lesson in family values. Cell. 1995;80:529–532
- Nuclear factor-kappa B is constitutively activated in primitive human acute myelogenous leukemia cells. Blood. 2001;98:2301–2307
- . Constitutive NF-kappa B DNA-binding activity in AML is frequently mediated by a Ras/PI3-K/PKB-dependent pathway. Leukemia. 2004;18:103–112
- . The roles of FLT3 in hematopoiesis and leukemia. Blood. 2002;100:1532–1542
- Internal tandem duplication of the FLT3 gene is preferentially seen in acute myeloid leukemia and myelodysplastic syndrome among various hematological malignancies. A study on a large series of patients and cell lines. Leukemia. 1997;11:1605–1609
- . Mechanism of constitutive activation of FLT3 with internal tandem duplication in the juxtamembrane domain. Oncogene. 2002;21:2555–2563
- The Flt3 internal tandem duplication mutant inhibits the function of transcriptional repressors by blocking interactions with SMRT. Blood. 2004;103:4650–4658
- . Flt3 mutation activates p21(WAF1/CIP1) gene expression through the action of STAT5. Biochem Biophys Res Commun. 2004;316:85–92
- FLT3 ligand causes autocrine signaling in acute myeloid leukemia cells. Blood. 2004;103:267–274
- Biologic and clinical significance of the FLT3 transcript level in acute myeloid leukemia. Blood. 2004;103:1901–1908
- Cloning of a coproporphyrinogen oxidase promoter regulatory element binding protein. Biochem Biophys Res Commun. 2000;273:596–602
- Phosphoinositide 3-kinase/Akt involvement in arsenic trioxide resistance of human leukemia cells. J Cell Physiol. 2005;202:623–634
- Cell death in human acute myelogenous leukemic cells induced by pyrrolidinedithiocarbamate. Apoptosis. 2003;8:539–545
- . Decreased expression of transcription factor GATA-2 in haematopoietic stem cells in patients with aplastic anaemia. Br J Haematol. 2001;113:52–57
- Stress-induced decrease in TRAF2 stability is mediated by Siah2. EMBO J. 2002;21:5756–5765
- . Genomic structure and regulation of a novel human gene, Klp1. Biochim Biophys Acta. 2001;1522:207–211
- . NF-kappa B is a target of AKT in anti-apoptotic PDGF signalling. Nature. 1999;401:86–90
- . Internal and external autocrine VEGF/KDR loops regulate survival of subsets of acute leukemia through distinct signaling pathways. Blood. 2004;103:3883–3889
- Stimulation of murine hemopoietic colony formation by human IL-6. J Immunol. 1988;140:3040–3044
- Synergism between interleukin-6 and interleukin-3 in supporting proliferation of human hematopoietic stem cells: comparison with interleukin-1 alpha. Blood. 1988;71:1759–1763
- Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines. Oncogene. 2000;19:624–631
- Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis. Blood. 2002;99:4326–4335
- Essential role of signal transducer and activator of transcription (Stat)5a but not (Stat)5b for Flt3-dependent signaling. J Exp Med. 2000;192:719–728
- Cytokine receptor common beta subunit-mediated STAT5 activation confers NF-kappa B activation in murine proB cell line Ba/F3 cells. J Biol Chem. 2002;277:6254–6265
- STAT5 induces macrophage differentiation of M1 leukemia cells through activation of IL-6 production mediated by NF-kappa B p65. J Immunol. 2001;167:3652–3660
- . Leukemia stem cells and constitutive activation of NF-kappa B. Blood. 2001;98:2291
- Single-agent CEP-701, a novel FLT3 inhibitor, shows biologic and clinical activity in patients with relapsed or refractory acute myeloid leukemia. Blood. 2004;103:3669–3676
PII: S0145-2126(05)00052-4
doi: 10.1016/j.leukres.2005.01.008
© 2005 Elsevier Ltd. All rights reserved.
« Previous
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Leukemia Research
Volume 29, Issue 8
, Pages 893-899
, August 2005
