Leukemia Research
Volume 29, Issue 6 , Pages 601-602 , June 2005

Complex and simple

  • Ephraim Philip Lansky

      Affiliations

    • Punisyn Pharmaceuticals, 1 HaDekalim Street, P.O. Box 9945, Haifa, Israel
    • ,
  • Daniel D. Von Hoff (Professor of Medicine, Professor of Pathology, Molecular and Cellular Biology, Director, Arizona Health Sciences Center's Cancer Therapeutics Program)

      Affiliations

    • Arizona Cancer Center, Rm. 4943A, 1515 N. Campbell Avenue, P.O. Box 245024, Tucson, AZ 85724, USA
    • Tel.: +1 520 626 2283.

Received 21 December 2004

References 

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  4. Anderson GL, Limacher M, Assaf AR, Bassford T, Beresford SA, Black H, et al. Women's Health Initiative Steering Committee. Effects of conjugated equine estrogen in postmenopausal women with hysterectomy: the women's health initiative randomized controlled trial. JAMA. 2004;291:1701–1712
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  8. Kawaii S, Lansky EP. Differentiation-promoting activity of pomegranate (Punica granatum) fruit extracts in HL-60 human promyelocytic leukemia cells. J Med Food. 2004;7:13–18
  9. Mertens-Talcott SU, Talcott ST, Percival SS. Low concentrations of quercetin and ellagic acid synergistically influence proliferation, cytotoxicity and apoptosis in MOLT-4 human leukemia cells. J Nutr. 2003;133:2669–2674
  10. Amoros M, Simoes CM, Girre L, Sauvager F, Cormier M. Synergistic effect of flavones and flavonols against herpes simplex virus type 1 in cell culture. Comparison with the antiviral activity of propolis. J Nat Prod. 1992;55:1732–1740
  11. Chan MM, Mattiacci JA, Hwang HS, Shah A, Fong D. Synergy between ethanol and grape polyphenols, quercetin, and resveratrol, in the inhibition of the inducible nitric oxide synthase pathway. Biochem Pharmacol. 2000;60:1539–1548
  12. Stermitz FR, Lorenz P, Tawara JN, Zenewicz LA, Lewis K. Synergy in a medicinal plant: antimicrobial action of berberine potentiated by 5′-methoxyhydnocarpin, a multidrug pump inhibitor. Proc Natl Acad Sci USA. 2000;97:1433–1437
  13. Curnis F, Sacchi A, Corti A. Improving chemotherapeutic drug penetration in tumors by vascular targeting and barrier alteration. J Clin Invest. 2002;110:475–482
  14. Lansky EP, Jiang W, Mo H, Bravo L, Froom P, Yu W, et al. Possible synergistic prostate cancer suppression by anatomically discrete pomegranate fractions. Invest New Drugs. 2005;23:11–20
  15. Lansky EP, Harrison G, Froom P, Jiang WG. Pomegranate (Punica granatum) pure chemicals show possible synergistic inhibition of human PC-3 prostate cancer cell invasion across Matrigel. Invest New Drugs. 2005;23:121–122
  16. Yeh LC, Tsai AD, Zavala MC, Lee JC. Cartilage-derived morphogenetic proteins enhance the osteogenic protein-1-induced osteoblastic cell differentiation of C2C12 cells. J Cell Physiol. 2004;201(3):401–408
  17. Williamson EM. Synergy and other interactions in phytomedicines. Phytomedicine. 2001;8:401–409
  18. Turgeon JL, McDonnell DP, Martin KA, Wise PM. Hormone therapy: physiological complexity belies therapeutic simplicity. Science. 2004;304:1269–1273
  19. Regalado A. A gentle scheme for unleashing chaos. Science. 1995;268:1848
  20. Jia W, Gao WY, Yan YQ, Wang J, Xu ZH, Zheng WJ, et al. The rediscovery of ancient Chinese herbal formulas. Phytother Res. 2004;18:681–686

PII: S0145-2126(05)00047-0

doi: 10.1016/j.leukres.2004.12.012

Leukemia Research
Volume 29, Issue 6 , Pages 601-602 , June 2005

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