Leukemia Research
Volume 29, Issue 8 , Pages 881-885 , August 2005

Aberrant DNA methylation of a cell cycle regulatory pathway composed of P73, P15 and P57KIP2 is a rare event in children with acute lymphocytic leukemia

  • Andreia A. Canalli

      Affiliations

    • Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    • ,
  • Hui Yang

      Affiliations

    • Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    • ,
  • Sima Jeha

      Affiliations

    • Department of Pediatrics, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    • ,
  • Koyu Hoshino

      Affiliations

    • Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    • ,
  • Blanca Sanchez-Gonzalez

      Affiliations

    • Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    • ,
  • Mark Brandt

      Affiliations

    • Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    • ,
  • Sherry Pierce

      Affiliations

    • Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    • ,
  • Hagop Kantarjian

      Affiliations

    • Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    • ,
  • Jean-Pierre Issa

      Affiliations

    • Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    • ,
  • Guillermo Garcia-Manero

      Affiliations

    • Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    • Corresponding Author InformationCorresponding author. Present address: Department of Leukemia, University of Texas MD Anderson Cancer Center, Unit 428, 1515 Holcombe Blvd., P.O. Box 301402, Houston, TX 77230-1402, USA. Tel.: +1 713 745 3428; fax: +1 713 794 4297.

Received 26 July 2004 ,Accepted 17 November 2004.

References 

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  3. Garcia-Manero G, Daniel J, Smith TL, Kornblau SM, Lee MS, Kantarjian HM, et al. DNA methylation of multiple promoter-associated CpG islands in adult acute lymphocytic leukemia. Clin Cancer Res. 2002;8:2217–2224
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  20. Roman-Gomez J, Jimenez-Velasco A, Castillejo JA, Agirre X, Barrios M, Navarro G, et al. Promoter hypermethylation of cancer-related genes is a strong independent prognostic factor in acute lymphoblastic leukemia. Blood. 2004;104:2492–2498
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PII: S0145-2126(05)00046-9

doi: 10.1016/j.leukres.2004.11.023

Leukemia Research
Volume 29, Issue 8 , Pages 881-885 , August 2005

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