Leukemia Research
Volume 29, Issue 7 , Pages 749-754 , July 2005

Myelodysplastic syndromes in patients under 50 years old: a single institution experience

  • Massimo Breccia

      Affiliations

    • Department of Cellular Biotechnology and Hematology, University La Sapienza, Rome, Italy
    • Corresponding Author InformationCorresponding author. Present address: Department of Human Biotechnology and Hematology, Via Benevento 6, 00161 Rome, Italy. Tel.: +39 06 85 79 51; fax: +39 06 44 24 19 84.
  • ,
  • Andrea Mengarelli

      Affiliations

    • Department of Haematology, Regina Elena Cancer Institute, Rome, Italy
  • ,
  • Marco Mancini

      Affiliations

    • Department of Cellular Biotechnology and Hematology, University La Sapienza, Rome, Italy
  • ,
  • Francesca Biondo

      Affiliations

    • Department of Cellular Biotechnology and Hematology, University La Sapienza, Rome, Italy
  • ,
  • Fabiana Gentilini

      Affiliations

    • Department of Cellular Biotechnology and Hematology, University La Sapienza, Rome, Italy
  • ,
  • Roberto Latagliata

      Affiliations

    • Department of Cellular Biotechnology and Hematology, University La Sapienza, Rome, Italy
  • ,
  • Franco Mandelli

      Affiliations

    • Department of Cellular Biotechnology and Hematology, University La Sapienza, Rome, Italy
  • ,
  • Giuliana Alimena

      Affiliations

    • Department of Cellular Biotechnology and Hematology, University La Sapienza, Rome, Italy

Received 23 December 2004 ,Accepted 3 January 2005.

References 

  1. Heaney ML, Golde DW, Myelodysplasia N. Engl J Med. 1999;340:1649–1660
  2. Steensma DP, Tefferi A. The myelodysplastic syndrome(s): a perspective and review highlighting current controversies. Leuk Res. 2003;27:95–120
  3. Aul C, Gattermann N, Schneider W. Epidemiological and etiological aspects of myelodysplastic syndromes. Leuk Lymphoma. 1995;16:247–262
  4. Fenaux P, Preudhomme C, Helene Estienne M, Morel P, Lai JL, Gardin C, et al. de novo myelodysplastic syndromes in adults aged 50 or less (A report on 37 cases). Leuk Res. 1990;14:1053–1059
  5. Chang KL, O’Donnell MR, Slovak ML, Dagis AC, Arber DA, Niland JC, et al. Primary myelodysplasia occurring in adults under 50 years old: a clinicopathologic study of 52 patients. Leukemia. 2002;16:623–631
  6. Sutton L, Chastang C, Ribaud P, Jouet JP, Kuentz M, Attal M, et al. Factors influencing outcome in de novo myelodysplastic syndromes treated by allogeneic bone marrow transplantation: a long-term study of 71 patients Societe Francaise de Greffe de Moelle. Blood. 1996;88:358–365
  7. Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DA, Gralnick HR, et al. Proposals for the classification of the myelodysplastic syndromes. Br J Haematol. 1982;51:189–199
  8. Mufti GJ, Stevens JR, Oscier DG, Hamblin TJ, Machin D. Myelodysplastic syndromes: a scoring system with prognostic significance. Br J Haematol. 1985;59:425–433
  9. Sanz GF, Sanz MA, Vallespi T, Canizo MC, Torrabadella M, Garcia S, et al. Two regression models and a scoring system for predicting survival and planning treatment in myelodysplastic syndromes: a multivariate analysis of prognostic factors in 370 patients. Blood. 1989;74:395–408
  10. Greenberg P, Cox C, LeBeau MM, Fenaux P, Morel P, Sanz G, et al. International scoring system for evaluating prognosis in myelodysplastic syndromes. Blood. 1997;89:2079–2088
  11. Johnson E, Cotter FE. Monosomy 7 and 7q-associated with myeloid malignancy. Blood Rev. 1997;11:46–55
  12. Hamblin TJ. Immunological abnormalities in myelodysplastic syndromes. Semin Hematol. 1996;33:150–162
  13. Smith SM, Le Beau MM, Huo D, Karrison T, Sobecks RM, Anastasi J, et al. Clinical-cytogenetic associations in 306 patients with therapy-related myelodysplasia and myeloid leukemia: the University of Chicago series. Blood. 2003;102:43–52
  14. Vallespi T, Imbert M, Mecucci C, Preudhomme C, Fenaux P. Diagnosis, classification and cytogenetics of myelodysplastic syndromes. Haematologica. 1998;83:258–275
  15. Nosslinger T, Reisner R, Koller E, Gruner H, Tuchler H, Nowotny H, et al. Myelodysplastic syndromes, from French-American-British to World Health Organization: comparison of classifications on 431 unselected patients from a single institution. Blood. 2001;98:2935–2941
  16. Fenaux P, Morel P, Lai JL. Cytogenetics of myelodysplastic syndromes. Semin Hematol. 1996;33:127–138
  17. Yunis JJ, Brunning RD. Prognostic significance of chromosomal abnormalities in acute leukaemias and myelodysplastic syndromes. Clin Haematol. 1986;15:597–620
  18. Luna-Fineman S, Shannon KM, Atwater SK, Davis J, Masterson M, Ortega J, et al. Myelodysplastic and myeloproliferative disorders of childhood: a study of 167 patients. Blood. 1999;93:459–466
  19. Hasle H, Arico M, Basso G, Biondi A, Cantu Rajnoldi A, Creutzig U, et al. Myelodysplastic syndrome, juvenile myelomonocytic leukemia, and acute myeloid leukemia associated with complete or partial monosomy 7 (European Working Group on MDS in Childhood (EWOG-MDS)). Leukemia. 1999;13:376–385

PII: S0145-2126(05)00039-1

doi: 10.1016/j.leukres.2005.01.003

Leukemia Research
Volume 29, Issue 7 , Pages 749-754 , July 2005