Leukemia Research
Volume 29, Issue 7 , Pages 813-820 , July 2005

Expression of mRNA and proteins for toll-like receptors, associated molecules, defensins and LL-37 by SRIK-NKL, a CD8+ NK/T cell line

  • Maya D. Srivastava

      Affiliations

    • Department of Allergy and Immunology, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland, OH 44195, USA
    • Corresponding Author InformationCorresponding author. Tel.: +1 216 444 6933; fax: +1 440 684 0928; pager: +1 800 329 3709.
    • ,
  • B.I.S Srivastava

      Affiliations

    • Department of Pathology and Laboratory Medicine, Roswell Park Cancer Institute, Buffalo, NY 14263, USA

Received 11 July 2004 ,Accepted 17 December 2004.

References 

  1. Lanier LL. NK cell receptors. Annu Rev Immunol. 1998;16:359–393
  2. Moretta A, Bottino C, Vitale M, Pende D, Blassoni R, Mingari MC, et al. Receptors for HLA class-I molecules in human natural killer cells. Annu Rev Immunol. 1996;14:619–648
  3. Biassoni R, Cantoni C, Pende D, Sivori S, Parolini S, Vitale M, et al. Human natural killer cell receptors and coreceptors. Immunol Rev. 2001;203–214
  4. Loza MJ, Perussia B. The IL-12 signature: NK cell terminal CD56+high stage and effector functions. J Immunol. 2004;172:88–96
  5. Ferlazzo G, Thomas D, Liu S, Goodman K, Morandi B, Muller WA, et al. The abundant NK cells in human secondary lymphoid tissue require activation to express killer cell Ig-like receptors and become cytolytic. J Immunol. 2004;172:1455–1462
  6. Leon F, Roldan E, Sanchez L, Camarero C, Bootello A, Roy G. Human small intestinal epithelium contains functional natural killer lymphocytes. Gastroenterology. 2003;125:345–356
  7. Koopman LA, Kopcow HD, Rybalow B, Boyson JE, Orange JS, Schatz F, et al. Human decidual National Killer cells are a unique NK cell subset with immunomodulatory potential. J Exp Med. 2003;198:1201–1212
  8. Hammond KJL, Godfrey DI. NKT cells: potential targets for autoimmune disease therapy. Tissue Antigens. 2002;159–363
  9. Moretta L, Romagnani C, Pietra G, Moretta A, Mingari MC. NK-CTLS, a novel HLA-E restricted T cell subset. Trends Immunol. 2003;24:136–143
  10. Akira S. Toll-like receptor signaling. J Biol Chem. 2003;278:38105–38108
  11. Lieu E, Ingalls RR. Toll-like receptors. Crit Care Med. 2002;30:S1–S11
  12. Lehrer RI, Ganz T. Defensins of vertebrate animals. Curr Opin Immunol. 2002;14:96–102
  13. Yang D, Biragyn A, Kwak LW, Oppeneheim JJ. Mammalian defensins in immunity: more than just micorbicidal. Trends Immunol. 2002;23:291–295
  14. Agerberth B, Charo J, Werr J, Olsson B, Idali F, Lindbom L, et al. The human antimicrobial and chemotactic peptides LL-37 and α-defensins are expressed by specific lymphocyte and monocyte populations. Blood. 2000;96:3086–3093
  15. Hornung V, Rothenfusser S, Britsch S, Krug A, Jahrsdoerfer B, Giese T, et al. Quantitative expression of Toll-like receptor 1-10 MRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CPG oligodeoxynucleotides. J Immunol. 2002;168:4531–4537
  16. Schmidt KM, Leung B, Kwong M, Zarember KA, Satyal S, Navas TA, et al. APC-independent activation of NK cells by the toll-like receptor 3 agonist double stranded RNA. J Immunol. 2004;172:138–143
  17. Bourke E, Bosisio D, Golay J, Polentarutti N, Mantovani A. The toll-like receptor repertoire of human B lymphocytes:inducible and selective expression of TLR-9 and TLR-10 in normal and transformed cells. Blood. 2003;102:956–996
  18. Sivori S, Falco M, Chiesa M, Simona C, Vitale M, Moretta L, et al. CpG and double stranded RNA trigger human NK cells by toll-like receptors: induction of cytokine release and cytotoxicity against tumors and dendritic cells. PNAS. 2004;101:10116–11012
  19. Obata-Onai A, Hashimoto S, Onai N, Kurachi M, Nagai S, Shizuno K, et al. Comprehensive gene expression analysis of human NK cells and CD8+ T lymphocytes. Int Immunol. 2002;14:1085–1098
  20. Armigoda SA, Yannaras NM, Melton AL, Srivastava MD. The innate immune system in human breast milk. Allergy and asthma proceedings. 2004; 25: 297–304.
  21. Zarember KA, Godowski PJ. Tissue expression of human Toll-like receptors and differential regulation of Toll-like MRNA in leukocytes in response to microbes, their products and cytokines. J Immunol. 2002;168:554–561
  22. Kanai Y, Ushinjima S, Kondo Y, Nakanishi Y, Hirohashi S. DNA methyl transferase expression and DNA methylation of CPG islands and peri-centromeric satellite regions in human colorectal and stomach cancers. Int J Cancer. 2001;91:205–212
  23. Zhang G, Ghosh S. Negative regulation of Toll-like receptor-mediated signaling by Tollip. J Biol Chem. 2002;277:7059–7065
  24. Iwasaki A, Medzhitov R. Toll-like receptor control of the adaptive immune responses. Nature Immunol. 2004;5:987–995
  25. Ochoa MT, Legaspi AJ, Hatziris Z, Godowski PJ, Modlin R, Sieling PA. Distribution of Toll like receptor 1 and Toll like receptor 2 in human lymphoid tissue. Immunology. 2003;108:10–15
  26. Hayashi F, Means TK, Luster AD. Toll-like receptors stimulate human neutrophil function. Blood. 2003;102:2660–2669
  27. Zhang L, Yu W, He T, Yu J, Caffrey RE, Dalmasso EA, et al. Contribution of human α defensins 1, 2 and 3 to the anti HIV-1 activity of CD8 antiviral factor defensins. Science. 2002;298:995–1000
  28. Levy JA. The search for the CD8+ cell anti-HIV factor (CAF). Trends Immunol. 2003;24:628–632

PII: S0145-2126(05)00034-2

doi: 10.1016/j.leukres.2004.12.016

Leukemia Research
Volume 29, Issue 7 , Pages 813-820 , July 2005

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