Therapy-related myelodysplastic syndrome in childhood: A retrospective study of 36 patients in Japan

Tsurusawa, M.; Manabe, A.; Hayashi, Y.; Akiyama, Y.; Kigasawa, H.; Inada, H.; Noguchi, Y.; Sawai, N.; Kobayashi, R.; Nagatoshi, Y.; Kawakami, K.; Kojima, S.; Nakahata, T.; MDS committee of the Japanese Society of Pediatric Hematology,

doi:10.1016/j.leukres.2004.11.018

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Volume 29, Issue 6 , Pages 625-632, June 2005

Therapy-related myelodysplastic syndrome in childhood: A retrospective study of 36 patients in Japan

M. Tsurusawa
- Department of Pediatrics, Faculty of Medicine, Aichi Medical University, Aichi 4801195, Japan
- Corresponding author. Tel.: +81 56162 3311; fax: +81 56162 2886.
A. Manabe
- Department of Pediatrics, St Luke's International Hospital, Tokyo, Japan
Y. Hayashi
- Department of Hematology/Oncology, Gunma Children's Medical Center, Gunma, Japan
Y. Akiyama
- Department of Pediatrics, Kyoto National Medical Center, Kyoto, Japan
H. Kigasawa
- Division of Hematology, Kanagawa Children's Medical Center, Kanagawa, Japan
H. Inada
- Department of Pediatrics, School of Medicine, Kurume University, Fukuoka, Japan
Y. Noguchi
- Department of Pediatric Hematology/Oncology, Narita Red Cross Hospital, Chiba, Japan
N. Sawai
- Department of Pediatrics, Komoro Kosei General Hospital, Nagano, Japan
R. Kobayashi
- Department of Pediatrics, School of Medicine, Hokkaido University, Sapporo, Japan
Y. Nagatoshi
- Department of Pediatrics, National Kyusyu Cancer Center, Fukuoka, Japan
K. Kawakami
- Department of Pediatrics, Kagoshima City Hospital, Kagoshima, Japan
S. Kojima
- Department of Pediatrics, Graduate School of Medicine, Nagoya University, Nagoya, Japan
T. Nakahata
- Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan
MDS committee of the Japanese Society of Pediatric Hematology

Received 15 September 2004; accepted 29 November 2004. published online 07 March 2011.

Abstract

We report here a retrospective analysis of 36 children with therapy-related myelodysplastic syndrome (t-MDS) diagnosed between 1990 and 1999 in Japan. Their median age was 7.7 years and the median latency period for the development of t-MDS was 38.5 months. The primary tumors were hematologic in 15 of the cases and nonhematologic in 21. Chromosomal abnormalities were detected in 32/34(94%) patients: abnormalities of chromosomes 5and/or 7 in 41% and notably, 11q23 abnormalities in 31%. The prognosis of children with t-MDS was very poor as compared to children with primary MDS (5 year survival: 16% versus 54%, p<0.0001).