Leukemia Research
Volume 29, Issue 6 , Pages 653-659 , June 2005

Methylation of p15INK4b and E-cadherin genes is independently correlated with poor prognosis in acute myeloid leukemia

  • Takashi Shimamoto

      Affiliations

    • First Department of Internal Medicine, Tokyo Medical University, 6-7-1, Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan
    • ,
  • Junko H. Ohyashiki

      Affiliations

    • Interactable Immune Disease Research Research Center, Tokyo Medical University, Shinjuku-ku, Tokyo, Japan
    • ,
  • Kazuma Ohyashiki

      Affiliations

    • First Department of Internal Medicine, Tokyo Medical University, 6-7-1, Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan
    • Corresponding Author InformationCorresponding author. Tel.: +81 3 3342 6111; fax: +81 3 5381 6651.

Received 26 July 2004 ,Accepted 17 November 2004.

References 

  1. Shingal R, Ginder GD. DNA methylation. Blood. 1999;93:4059–4070
  2. Kass SU, Pruss D, Wolffe AP. How does DNA methylation repress transcription?. Trends Genet. 1997;13:444–449
  3. Bartolomei MS, Tilghman SM. Genomic imprinting in mammals. Annu Rev Genet. 1997;31:493–525
  4. Nakao M, Sasaki H. Genomic imprinting: significance in development and diseases and the molecular mechanisms. J Biochem (Tokyo). 1996;120:467–473
  5. Panning B, Jaenisch R. RNA and the epigenetic regulation of X chromosome inactivation. Cell. 1998;93:305–308
  6. Laird PW, Jaenisch R. DNA methylation and cancer. Hum Mol Genet. 1994;3:1487–1495
  7. Jones PA, Laird PW. Cancer epigenetics comes of age. Nat Genet. 1999;21:163–167
  8. Sakai T, Toguchida J, Ohtani N, Yandell DW, Rapaport JM, Dryja TP. Allele-specific hypermethylation of the retinoblastoma tumor-suppressor gene. Am J Hum Genet. 1991;48:880–888
  9. Herman JG, Latif F, Weng Y, et al. Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma. Proc Natl Acad Sci USA. 1994;91:9700–9704
  10. Herman JG, Merlo A, Mao L, et al. Inactivation of CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common cancers. Cancer Res. 1995;55:4525–4530
  11. Herman JG, Graff JR, Myohanen S, Nelkin BD, Baylin SB. Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci USA. 1996;93:9821–9826
  12. Serrano M, Hannon GJ, Beach D. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature. 1993;366:704–707
  13. Hannon GJ, Beach D. p15INK4B is a potential effector of TGF-β-induced cell cycle arrest. Nature. 1994;371:257–261
  14. Morgan DO. Principles of CDK regulation. Nature. 1995;374:131–134
  15. Serrano M, Lee H, Chin L, Cordon-Cardo C, Beach D, DePinho RA. Role of the INK4a locus in tumor suppression and cell mortality. Cell. 1996;85:27–37
  16. Herman JG, Civin CI, Issa JPJ, Collector MI, Sharkis SJ, Baylin SB. Distinct patterns of inactivation of p15INK4B and p16INK4A characterize the major types of hematological malignancies. Cancer Res. 1997;57:837–841
  17. Wong IHN, Ng MHL, Huang DP, Lee JCK. Aberrant p15 promoter methylation in adult and childhood acute leukemias of nearly all morphologic subtypes: potential prognostic implications. Blood. 2000;95:1942–1949
  18. Quesnel B, Guillerm G, Vereecque R, et al. Methylation of the p15INK4b gene in myelodysplastic syndromes is frequent and acquired during disease progression. Blood. 1998;91:2985–2990
  19. Karayiannakis AJ, Syrigos KN, Chatzigianni E, et al. Aberrant E-cadherin expression associated with loss of differentiation and advanced stage in human pancreatic cancer. Anticancer Res. 1998;18:4177–4180
  20. Sulzer MA, Leers MP, van Noord JA, Bollen EC, Theunissen PH. Reduced E-cadherin expression is associated with increased lymph node metastasis and unfavorable prognosis in non-small cell lung cancer. Am J Respir Crit Care Med. 1998;157:1319–1323
  21. Zheng Z, Pan J, Chu B, Wong YC, Cheung AL, Tsao SW. Downregulation and abnormal expression of E-cadherin and β-catenin in nasopharyngeal carcinoma: close association with advanced disease stage and lymph node metastasis. Hum Pathol. 1999;30:458–466
  22. Melki JR, Vincent PC, Brown RD, Clark SJ. Hypermethylation of E-cadherin in leukemia. Blood. 2000;95:3208–3213
  23. Corn PG, Smith BD, Ruckdeschel ES, Douglas D, Baylin SB, Herman JG. E-cadherin expression is silenced by 5′ CpG island methylation in acute leukemia. Clin Cancer Res. 2000;6:4243–4248
  24. Kurakawa E, Shimamoto T, Utsumi K, Hirano T, Kato H, Ohyashiki K. Hypermethylation of p16INK4a and p15INK4b genes in non-small cell lung cancer. Int J Oncol. 2001;19:277–281
  25. Melki JR, Vincent PC, Clark SJ. Concurrent DNA hypermethylation of multiple genes in acute myeloid leukemia. Cancer Res. 1999;59:3730–3740
  26. Dodge JE, List AF, Futscher BW. Selective variegated methylation of the p15 CpG island in acute myeloid leukemia. Int J Cancer. 1998;78:561–567
  27. Drexler HG. Review of alterations of the cyclin-dependent kinase inhibitor INK4 family genes p15, p16, p18 and p19 in human leukemia-lymphoma cells. Leukemia. 1998;12:845–859
  28. Quesnel B, Fenaux P. P15INK4b gene methylation and myelodysplastic syndromes. Leuk Lymphoma. 1999;35:437–443
  29. Guo SX, Taki T, Ohnishi H, et al. Hypermethylation of p16 and p15 genes and RB protein expression in acute leukemia. Leuk Res. 2000;24:39–46
  30. Tien HF, Tang JL, Tsay W, et al. Methylation of the p15INK4B gene in myelodysplastic syndrome: it can be detected early at diagnosis or during disease progression and is highly associated with leukaemic transformation. Br J Haematol. 2001;112:148–154
  31. Das-Gupta EP, Russell NH. Anticorresponding p15 promoter methylation and microsatellite instability in acute myeloblastic leukemia. Blood. 2000;96:2002
  32. Paul R, Ewing CM, Jarrard DF, Issacs WB. The cadherin cell-cell adhesion pathway in prostate cancer progression. Br J Urol. 1997;79(Suppl. 1):37–43
  33. Lee Y-C, Wu C-T, Chen C-S, Chang Y-L. E-cadherin expression in surgically-resected non-small cell lung cancers—a clinicopathological study. Thorac Cardiovas Surg. 2000;48:294–299
  34. Graff JR, Gabrielson E, Fujii H, Baylin SB, Herman JG. Methylation patterns of the E-cadherin 5′ CpG island are unstable and reflect the dynamic, heterogenous loss of E-cadherin expression during metastatic progression. J Biol Chem. 2000;275:2727–2732
  35. Armeanu S, Buhring HJ, Reuss-Borst M, Muller CA, Klein G. E-cadherin is functionally involved in the maturation of the erythroid lineage. J Cell Biol. 1995;131:243–249
  36. Buhring HJ, Muller T, Herbst R, et al. The adhesion molecule E-cadherin and a surface antigen recognized by the antibody 9C4 are selectively expressed on erythroid cells of defined maturational stages. Leukemia. 1996;10:106–116
  37. Byad JC, Weiss RB. An unusual variation of acute myelogenous leukemia associated with 8;21 chromosomal translocation and blast expression of the neural cell adhesion molecule. Cancer. 1994;73:2107–2112
  38. Chim CS, Tam CYY, Liang R, Kwong YL. Methylation of p15 and p16 genes in adult acute leukemia. Lack of prognostic significance. Cancer. 2001;91:2222–2229

PII: S0145-2126(04)00398-4

doi: 10.1016/j.leukres.2004.11.014

Leukemia Research
Volume 29, Issue 6 , Pages 653-659 , June 2005

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