Leukemia Research
Volume 29, Issue 6 , Pages 633-639 , June 2005

TEL/AML1 and immunoreceptor gene rearrangements—which comes first?

  • Jan Zuna

      Affiliations

    • CLIP - Childhood Leukaemia Investigation Prague, 2nd Medical School, Charles University Prague, V Uvalu 84, Prague, Czech Republic
    • Department of Paediatric Haematology and Oncology, 2nd Medical School, Charles University Prague, V Uvalu 84, 150 06 Prague 5, Czech Republic
    • Corresponding Author InformationCorresponding author. Tel.: +420 22443 6580; fax: +420 22443 6521.
    • ,
  • Ondrej Krejci

      Affiliations

    • CLIP - Childhood Leukaemia Investigation Prague, 2nd Medical School, Charles University Prague, V Uvalu 84, Prague, Czech Republic
    • Department of Paediatric Haematology and Oncology, 2nd Medical School, Charles University Prague, V Uvalu 84, 150 06 Prague 5, Czech Republic
    • ,
  • Jozef Madzo

      Affiliations

    • CLIP - Childhood Leukaemia Investigation Prague, 2nd Medical School, Charles University Prague, V Uvalu 84, Prague, Czech Republic
    • Department of Paediatric Haematology and Oncology, 2nd Medical School, Charles University Prague, V Uvalu 84, 150 06 Prague 5, Czech Republic
    • ,
  • Eva Fronkova

      Affiliations

    • CLIP - Childhood Leukaemia Investigation Prague, 2nd Medical School, Charles University Prague, V Uvalu 84, Prague, Czech Republic
    • Department of Paediatric Haematology and Oncology, 2nd Medical School, Charles University Prague, V Uvalu 84, 150 06 Prague 5, Czech Republic
    • ,
  • Lucie Sramkova

      Affiliations

    • CLIP - Childhood Leukaemia Investigation Prague, 2nd Medical School, Charles University Prague, V Uvalu 84, Prague, Czech Republic
    • Department of Paediatric Haematology and Oncology, 2nd Medical School, Charles University Prague, V Uvalu 84, 150 06 Prague 5, Czech Republic
    • ,
  • Ondrej Hrusak

      Affiliations

    • CLIP - Childhood Leukaemia Investigation Prague, 2nd Medical School, Charles University Prague, V Uvalu 84, Prague, Czech Republic
    • Department of Immunology, 2nd Medical School, Charles University Prague, V Uvalu 84, Prague, Czech Republic
    • ,
  • Tomas Kalina

      Affiliations

    • CLIP - Childhood Leukaemia Investigation Prague, 2nd Medical School, Charles University Prague, V Uvalu 84, Prague, Czech Republic
    • Department of Immunology, 2nd Medical School, Charles University Prague, V Uvalu 84, Prague, Czech Republic
    • ,
  • Martina Vaskova

      Affiliations

    • CLIP - Childhood Leukaemia Investigation Prague, 2nd Medical School, Charles University Prague, V Uvalu 84, Prague, Czech Republic
    • Department of Immunology, 2nd Medical School, Charles University Prague, V Uvalu 84, Prague, Czech Republic
    • ,
  • Jan Stary

      Affiliations

    • Department of Paediatric Haematology and Oncology, 2nd Medical School, Charles University Prague, V Uvalu 84, 150 06 Prague 5, Czech Republic
    • ,
  • Jan Trka

      Affiliations

    • CLIP - Childhood Leukaemia Investigation Prague, 2nd Medical School, Charles University Prague, V Uvalu 84, Prague, Czech Republic
    • Department of Paediatric Haematology and Oncology, 2nd Medical School, Charles University Prague, V Uvalu 84, 150 06 Prague 5, Czech Republic
    • ,
  • The Czech Paediatric Haematology Working Group (CPH)

Received 10 August 2004 ,Accepted 23 November 2004.

References 

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  2. Ford AM, Bennett CA, Price CM, Bruin MC, Van Wering ER, Greaves M. Fetal origins of the TEL-AML1 fusion gene in identical twins with leukaemia. Proc Natl Acad Sci USA. 1998;95:4584–4588
  3. Wiemels JL, Ford AM, Van Wering ER, Postma A, Greaves M. Protracted and variable latency of acute lymphoblastic leukemia after TEL-AML1 gene fusion in utero. Blood. 1999;94:1057–1062
  4. Wiemels JL, Cazzaniga G, Daniotti M, Eden OB, Addison GM, Masera G, et al. Prenatal origin of acute lymphoblastic leukaemia in children. Lancet. 1999;354:1499–1503
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  7. Szczepanski T, Willemse MJ, van Wering ER, van Weerden JF, Kamps WA, van Dongen JJ. Precursor-B-ALL with D(H)-J(H) gene rearrangements have an immature immunogenotype with a high frequency of oligoclonality and hyperdiploidy of chromosome 14. Leukemia. 2001;15:1415–1423
  8. Van Dongen JJ, Wolvers-Tettero IL. Analysis of immunoglobulin and T-cell receptor genes. Part I: basic and technical aspects. Clin Chim Acta. 1991;198:1–91
  9. Krejci O, Prouzova Z, Horvath O, Trka J, Hrusak O. Cutting edge: TCR delta gene is frequently rearranged in adult B lymphocytes. J Immunol. 2003;171:524–527
  10. van der Burg M, Barendregt BH, Szczepanski T, van Wering ER, Langerak AW, van Dongen JJ. Immunoglobulin light chain gene rearrangements display hierarchy in absence of selection for functionality in precursor-B-ALL. Leukemia. 2002;16:1448–1453
  11. Hubner S, Cazzaniga G, Flohr T, van der Velden VH, Konrad M, Potschger U, et al. High incidence and unique features of antigen receptor gene rearrangements in TEL-AML1-positive leukemias. Leukemia. 2004;18:84–91
  12. Ford AM, Fasching K, Panzer-Grumayer ER, Koenig M, Haas OA, Greaves MF. Origins of “late” relapse in childhood acute lymphoblastic leukemia with TEL-AML1 fusion genes. Blood. 2001;98:558–564
  13. Zuna J, Ford A, Peham M, Patel N, Saha V, Eckert C, et al. TEL deletion analysis supports a novel view of relapse in childhood acute lymphoblastic leukemia. Clin Cancer Res. 2004;10:5355–5360
  14. Taub JW, Konrad MA, Ge Y, Naber JM, Scott JS, Matherly LH, et al. High frequency of leukemic clones in newborn screening blood samples of children with B-precursor acute lymphoblastic leukemia. Blood. 2002;99:2992–2996
  15. Peham M, Konrad M, Harbott J, Konig M, Haas OA, Panzer-Grumayer ER. Clonal variation of the immunogenotype in relapsed ETV6/RUNX1-positive acute lymphoblastic leukemia indicates subclone formation during early stages of leukemia development. Genes Chromosomes Cancer. 2004;39:156–160
  16. Yeoh EJ, Ross ME, Shurtleff SA, Williams WK, Patel D, Mahfouz R, et al. Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling. Cancer Cell. 2002;1:133–143

PII: S0145-2126(04)00392-3

doi: 10.1016/j.leukres.2004.11.007

Leukemia Research
Volume 29, Issue 6 , Pages 633-639 , June 2005

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