Leukemia Research
Volume 29, Issue 6 , Pages 617-623 , June 2005

Prognostic significance of FLT3 mutations in pediatric non-promyelocytic acute myeloid leukemia

  • Hyoung Jin Kang

      Affiliations

    • Pediatric Oncology Branch, Division of Specific Organs Cancer, National Cancer Center, Goyang, Gyeonggi, Republic of Korea
    • ,
  • Seung-Hee Hong

      Affiliations

    • Molecular Oncology Branch, Division of Basic Sciences, National Cancer Center, Goyang, Gyeonggi, Republic of Korea
    • ,
  • In Hoo Kim

      Affiliations

    • Molecular Oncology Branch, Division of Basic Sciences, National Cancer Center, Goyang, Gyeonggi, Republic of Korea
    • ,
  • Byung-Kiu Park

      Affiliations

    • Pediatric Oncology Branch, Division of Specific Organs Cancer, National Cancer Center, Goyang, Gyeonggi, Republic of Korea
    • ,
  • Kyou Sup Han

      Affiliations

    • Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
    • ,
  • Han Ik Cho

      Affiliations

    • Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
    • ,
  • Hee Young Shin

      Affiliations

    • Division of Hematology/Oncology, Department of Pediatrics, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul 110-744, Republic of Korea
    • Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea
    • ,
  • Hyo Seop Ahn

      Affiliations

    • Division of Hematology/Oncology, Department of Pediatrics, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul 110-744, Republic of Korea
    • Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea
    • Corresponding Author InformationCorresponding author. Tel.: +82 2 2072 3625; fax: +82 2 743 3455.

Received 7 September 2004 ,Accepted 2 November 2004.

References 

  1. Rowe JM, Tallman MS. Intensifying induction therapy in acute myeloid leukemia: has a new standard of care emerged?. Blood. 1997;90:2121–2126
  2. Woods WG, Neudorf S, Gold S, Sanders J, Buckley JD, Barnard DR, et al. A comparison of allogeneic bone marrow transplantation, autologous bone marrow transplantation, and aggressive chemotherapy in children with acute myeloid leukemia in remission. Blood. 2001;97:56–62
  3. Ravindranath Y, Yeager AM, Chang MN, Steuber CP, Krischer J, Graham-Pole J, et al. Autologous bone marrow transplantation versus intensive consolidation chemotherapy for acute myeloid leukemia in childhood. Pediatric Oncology Group. N Engl J Med. 1996;334:1428–1434
  4. Amadori S, Testi AM, Arico M, Comelli A, Giuliano M, Madon E, et al. Prospective comparative study of bone marrow transplantation and post-remission chemotherapy for childhood acute myelogenous leukaemia. The Associazione Italiana Ematologia ed Oncologia Pediatrica Cooperative Group. J Clin Oncol. 1993;11:1046–1054
  5. Kottaridis PD, Gale RE, Linch DC. Prognostic implications of the presence of FLT3 mutations in patients with acute myeloid leukemia. Leukemia Lymphoma. 2003;44:905–913
  6. Meshinchi S, Smith FO, Arceci RJ. Prognostic factors and risk-based therapy in pediatric acute myeloid leukemia. Curr Oncol Rep. 2003;5:489–497
  7. Lowenberg B, Griffin JD, Tallman MS. Acute myeloid leukemia and acute promyelocytic leukaemia. Hematology (Am Soc Hematol Educ Program). 2003;82–101
  8. Meshinchi S, Woods WG, Stirewalt DL, Sweetser DA, Buckley JD, Tjoa TK, et al. Prevalence and prognostic significance of Flt3 internal tandem duplication in pediatric acute myeloid leukemia. Blood. 2001;97:89–94
  9. Meshinchi S, Stirewalt DL, Alonzo TA, Zhang Q, Sweetser DA, Woods WG, et al. Activating mutations of RTK/ras signal transduction pathway in pediatric acute myeloid leukemia. Blood. 2003;102:1474–1479
  10. Iwai T, Yokota S, Nakao M, Okamoto T, Taniwaki M, Onodera N, et al. Internal tandem duplication of the FLT3 gene and clinical evaluation in childhood acute myeloid leukemia. The Children's Cancer and Leukemia Study Group, Japan. Leukemia. 1999;13:38–43
  11. Kondo M, Horibe K, Takahashi Y, Matsumoto K, Fukuda M, Inaba J, et al. Prognostic value of internal tandem duplication of the FLT3 gene in childhood acute myelogenous leukemia. Med Pediatr Oncol. 1999;33:525–529
  12. Xu F, Taki T, Yang HW, Hanada R, Hongo T, Ohnishi H, et al. Tandem duplication of the FLT3 gene is found in acute lymphoblastic leukaemia as well as acute myeloid leukaemia but not in myelodysplastic syndrome or juvenile chronic myelogenous leukaemia in children. Br J Haematol. 1999;105:155–162
  13. Liang DC, Shih LY, Hung IJ, Yang CP, Chen SH, Jaing TH, et al. Clinical relevance of internal tandem duplication of the FLT3 gene in childhood acute myeloid leukemia. Cancer. 2002;94:3292–3298
  14. Zwaan CM, Meshinchi S, Radich JP, Veerman AJ, Huismans DR, Munske L, et al. FLT3 internal tandem duplication in 234 children with acute myeloid leukemia: prognostic significance and relation to cellular drug resistance. Blood. 2003;102:2387–2394
  15. Drexler HG. Expression of FLT3 receptor and response to FLT3 ligand by leukemic cells. Leukemia. 1996;10:588–599
  16. Gilliland DG, Griffin JD. The roles of FLT3 in hematopoiesis and leukemia. Blood. 2002;100:1532–1542
  17. Stirewalt DL, Radich JP. The role of FLT3 in haematopoietic malignancies. Nat Rev Cancer. 2003;3:650–665
  18. Kang HJ, Shin HY, Choi HS, Han KS, Ahn HS. Autologous peripheral blood stem cell transplantation with BCVAC conditioning in childhood acute myeloid leukemia. Bone Marrow Transplant. 2004;33:471–476
  19. Park HS, Kim DW, Kim CC, Kim HK, Kim JS, Hwang TJ, et al. Induction chemotherapy with idarubicin plus N4-behenoyl-1-beta-d-arabinofuranosylcytosine in acute myelogenous leukemia: a newly designed induction regimen—a prospective, cooperative multicenter study. Semin Hematol. 1996;33:24–29
  20. Ebb DH, Weinstein HJ. Diagnosis and treatment of childhood acute myelogenous leukemia. Pediatr Clin North Am. 1997;44:847–862
  21. Grimwade D, Walker H, Oliver F, Wheatley K, Harrison C, Harrison G, et al. The importance of diagnostic cytogenetics on outcome in AML: analysis of 1,612 patients entered into the MRC AML 10 trial. The Medical Research Council Adult and Children's Leukaemia Working Parties. Blood. 1998;92:2322–2333
  22. Stevens RF, Hann IM, Wheatley K, Gray RG. Marked improvements in outcome with chemotherapy alone in paediatric acute myeloid leukemia: results of the United Kingdom Medical Research Council's 10th AML trial. MRC Childhood Leukaemia Working Party. Br J Haematol. 1998;101:130–140
  23. Brown P, Small D. FLT3 inhibitors: a paradigm for the development of targeted therapeutics for paediatric cancer. Eur J Cancer. 2004;4:707–721
  24. Smith BD, Levis M, Beran M, Giles F, Kantarjian H, Berg K, et al. Blood. 2004;103:3669–3676

PII: S0145-2126(04)00390-X

doi: 10.1016/j.leukres.2004.11.006

Leukemia Research
Volume 29, Issue 6 , Pages 617-623 , June 2005

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